Peripheral location of the Y chromosome: Relationship to race and length heteromorphism

Abstract

SUMMARYIn the present report we examined the position of the Y chromosome with respect to its size and race to determine their relationship to its peripheral location. Peripheral blood lymphocytes were cultured from 172 normal male individuals (70 Asian Indians; 49 American Blacks; and 53 Caucasians) and 2770 QFQ cells were photographed. The length of the Y chromosome was classified into four groups i.e., small, average, large and very large as described earlier (Verma etaL, J. Med. Genet., 15,227-281. 1978). The average incidence of peripheral location of all races for small, average, large and very large was 364, 5'84, 1051 and 11'17 per cent respectively. For blacks and caucasians, the peripheral location was influenced by its size while the incidence remained the same for Indians for all sizes. Consequently, it is presumed that the position of the Y chromosome in somatic metaphases depends upon race as well as its size.Furthermore, we have provided a method for determining the position of the Y chromosome which should suffice for most situations.

Spatial relationship of chromosomes 9 and 22 at metaphase in patients with chronic myelogenous leukemia (CML)

“…In 1980), the late replicating X and the Y chromosomes being addition, the position of Y chromosome in 16 individuals peripheral more often than other chromosomes. This notion, whose Y was equivalent to chromosome 22 was also identified however, has been challenged (Verma et al, 1984;Dosik et and all possible distances between normal and abnormal chroal., 1984;Dosik and Verma, 1983). A similar controversy mosomes 9 and 22 were also measured.…”

Spatial Relationship between Ph and Normal Chromosome 22 at Somatic Metaphase in Chronic Myelogenous Leukemia

“…The factors responsible for producing a unique degree or order to the arrangement of chromosomes in the nucleus are the subject of controversy and many reviews [1][2][3][4], In humans, the most obvious examples are satellite associations between acrocentric chro mosomes 13-15, 21 and 22. Exhaustive attempts have been made towards understanding the mechanisms of somatic association of acrocentric chromosomes [5].…”