Peripheral leukocyte response to oncological radiotherapy: Expression of heat shock proteins

Guisasola, M.C.; Marcos, Pilar; Şimon, Ioan; Villanueva, Florentina; Andrès, Emmanuel; Suárez, Antonio; García‐Barreno, Pedro

doi:10.1080/09553000600643516

Cited by 8 publications

(2 citation statements)

References 45 publications

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“…However, this apparent difference was not statistically significant ( P >0.05) and therefore does not seem to explain completely the mechanism by which the CC/CG genotype reduced mortality risk in that study. In another study, Guisasola et al [19] reported that radiotherapy caused HSP27 downregulation, to the greatest extent in patients with the largest irradiated volumes, and led to decreased intracellular HSP levels. Thus, we hypothesize that patients carrying the rs2868371 CC genotype may have less HSP27 downregulation than those carrying other genotypes after radiotherapy and therefore may overexpress HSP27.…”

Section: Discussionmentioning

confidence: 99%

HSPB1 Gene Polymorphisms Predict Risk of Mortality for US Patients After Radio(chemo)therapy for Non-Small Cell Lung Cancer

Wei

Guerra

et al. 2012

International Journal of Radiation Oncology*Biology*Physics

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Purpose We investigated potential associations between single-nucleotide polymorphisms (SNPs) in the heat shock protein beta-1 (HSPB1) gene and overall survival in U.S. patients with non–small-cell lung cancer (NSCLC). Materials and Methods Using available genomic DNA samples from 224 patients with NSCLC treated with definitive radio(chemo)therapy, we genotyped two SNPs of HSPB1 (rs2868370 and rs2868371). We used both Kaplan-Meier cumulative probability and Cox proportional hazards analyses to evaluate the effect of HSPB1 genotypes on survival. Results Our cohort comprised 117 men and 107 women, mostly white (79.5%), with a median age of 70 years. The median radiation dose was 66 Gy (range 63–87.5 Gy), and 183 patients (82%) received concurrent platinum-based chemotherapy. The most common genotype of the rs2868371 SNP was CC (61%). Univariate and multivariate analyses showed that this genotype was associated with poorer survival than carriers of CG/GG genotypes (univariate hazard ratio [HR]=1.39, 95% confidence interval [CI] 1.02–1.90, P = 0.037; multivariate HR=1.39; 95% CI 1.01–1.92; P = 0.045). Conclusion Our results show that the CC genotype of HSPB1 rs2868371 was associated with poorer overall survival in patients with NSCLC after radio(chemo)therapy, findings that contradict those of a previous study of Chinese patients. Validation of our findings with larger numbers of similar patients is needed, as are mechanical and clinical studies to determine the mechanism underlying these associations.

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Section: Discussionmentioning

confidence: 99%

HSPB1 Gene Polymorphisms Predict Risk of Mortality for US Patients After Radio(chemo)therapy for Non-Small Cell Lung Cancer

Wei

Guerra

et al. 2012

International Journal of Radiation Oncology*Biology*Physics

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“…The Hsp27 level prior to treatment was suggested as a prognostic biomarker for radiation tolerance. NSCLC patients with the greatest interleukocyte Hsp27 levels before treatment suffered more severe acute radiation morbidity (Guisasola et al 2006 ). Lopez Guerra et al investigated the association of the HSPB1 rs2868371 polymorphism with radiation-induced esophageal toxicity in radio(chemo)therapy treated NSCLC patients.…”

Section: Hspb1 Variants In Lung Cancermentioning

confidence: 98%

Small HSP Variants and Human Diseases

Guo

2015

Heat Shock Proteins

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Small heat shock proteins (sHSPs) are key members of the HSP superfamily that are ubiquitous among all organisms. The amino acid sequences of the sHSPs are not as highly conserved as the larger HSPs but it comprises a characteristic α-crystallin domain (ACD). The mammalian sHSP family, now referred to as the HSPB family, includes 11 members: HSP27/HSPB1, MKBP (myotonic dystrophy protein kinase-binding protein)/HSPB2, HSPB3, alphaA-crystallin / HSPB4, alphaB-crystallin/HSPB5, HSP20/HSPB6, cvHSP (cardiovascular heat shock protein)/HSPB7, HSP22/HSPB8, HSPB9, ODF1 (outer dense fi ber protein)/ HSPB10, and HSPB11. They have been reported to have a wide range of cellular functions, including endowing cells with thermotolerance and acting as molecular chaperones. Because of these functions, sHSPs can participate in a large number of fundamental cellular processes such as controlling protein folding, F-actindependent processes, cytoprotection/anti-apoptosis, differentiation, cell proliferation, and gene expression, and thereby are involved in many pathological diseases, such as neurodegenerative diseases, cancer, and cardiovascular diseases. Genetic mutation or variations of sHSPs genes may change their expression levels and affect protein functions, thus contributing to cell malfunction especially during stress.Here we examined the current reports regarding the mutations or variations of sHSPs genes, and we analyzed their associations with the development, progression, and prognosis of some human diseases. We also addressed the biological functions for the potential causal sHSPs variations and discussed their possible implications in human diseases.

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HSPB1 polymorphisms might be associated with radiation-induced damage risk in lung cancer patients treated with radiotherapy

Cheng

et al. 2016

Tumor Biol.

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Several studies investigating the association between heat shock protein beta-1 (HSPB1) polymorphisms and radiation-induced damage in lung cancer patients administrated with radiotherapy have derived conflicting results. This meta-analysis aimed to assess the association between the HSPB1 genes' (rs2868370 and rs2868371) polymorphisms and the risk of radiation-induced damage in lung cancer patients. After an electronic literature search, four articles including six studies were found to be eligible for this meta-analysis. No association was observed between rs2868370 genotypes and radiation-induced damage risk. However, rs2868371 showed a statistically increased risk of radiation-induced damage under CC vs. CG/GG model (OR = 1.59, 95 % CI = 1.10-2.29). Subgroup analysis by ethnicity showed that the genotypes of rs2868371 were also associated with a significantly increased risk of radiation-induced damage in CC vs. CG/GG model (OR = 1.86, 95 % CI = 1.21-2.83) among mixed ethnicities which are mainly comprised of white people. When the data was stratified by organ-damaged, a significant association was only observed in the esophagus group (OR = 2.94, 95 % CI = 1.35-6.37, for CC vs. CG/GG model). In conclusion, the present study demonstrated that the rs2868371 genotypes of HSPB1 might be associated with radiation-induced esophagus damage risk, especially in Caucasians but not in the Asian population.

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Peripheral leukocyte response to oncological radiotherapy: Expression of heat shock proteins

Cited by 8 publications

References 45 publications

HSPB1 Gene Polymorphisms Predict Risk of Mortality for US Patients After Radio(chemo)therapy for Non-Small Cell Lung Cancer

HSPB1 Gene Polymorphisms Predict Risk of Mortality for US Patients After Radio(chemo)therapy for Non-Small Cell Lung Cancer

Small HSP Variants and Human Diseases

HSPB1 polymorphisms might be associated with radiation-induced damage risk in lung cancer patients treated with radiotherapy

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