HSPB1 polymorphisms might be associated with radiation-induced damage risk in lung cancer patients treated with radiotherapy

Abstract

Several studies investigating the association between heat shock protein beta-1 (HSPB1) polymorphisms and radiation-induced damage in lung cancer patients administrated with radiotherapy have derived conflicting results. This meta-analysis aimed to assess the association between the HSPB1 genes' (rs2868370 and rs2868371) polymorphisms and the risk of radiation-induced damage in lung cancer patients. After an electronic literature search, four articles including six studies were found to be eligible for this meta-analysis. No association was observed between rs2868370 genotypes and radiation-induced damage risk. However, rs2868371 showed a statistically increased risk of radiation-induced damage under CC vs. CG/GG model (OR = 1.59, 95 % CI = 1.10-2.29). Subgroup analysis by ethnicity showed that the genotypes of rs2868371 were also associated with a significantly increased risk of radiation-induced damage in CC vs. CG/GG model (OR = 1.86, 95 % CI = 1.21-2.83) among mixed ethnicities which are mainly comprised of white people. When the data was stratified by organ-damaged, a significant association was only observed in the esophagus group (OR = 2.94, 95 % CI = 1.35-6.37, for CC vs. CG/GG model). In conclusion, the present study demonstrated that the rs2868371 genotypes of HSPB1 might be associated with radiation-induced esophagus damage risk, especially in Caucasians but not in the Asian population.

Validation of Polymorphisms Associated with the Risk of Radiation-Induced Oesophagitis in an Independent Cohort of Non-Small-Cell Lung Cancer Patients

“…This effect remains even when we replicate the analyses comparing patients by factors such as the use of concurrent chemoradiotherapy, the mean oesophageal dose and the percentage of oesophageal V40. Conflicting results have been described for the association of the SNP rs2868371 with radiation adverse effects, which have been related to variations in the distribution of the SNP genotype in different populations [ 25 ]. However, the similar distribution of the rs2868371 genotypes in our cohort (60.8% CC; 39.20% CG/GG) and the reference study (López Guerra et al [ 9 ]: experimental dataset, 60% CC and 40% CG/GG; validation dataset, 61% CC and 39% CG/GG) rules out this possibility.…”

The Association Between Heat-Shock Protein Polymorphisms and Prognosis in Lung Cancer Patients Treated With Platinum-Based Chemotherapy

“…We used Haploview version 4.2 to choose the Haplotype tagging SNPs. They were chosen based on our previous research HSPs and Rho GTPases SNPs were related to lung cancer platinum-based chemotherapy toxicity (Zou et al, 2016), and they were associated with the outcome of cancers and involvement in multiple cancers (Li et al, 2016;Hung et al, 2020). And the selected SNPs must meet the condition that the minor allele frequency (MAF)>0.05 in the HapMap CHB population.…”

“…The overriding role of the HSPs is to stabilize the active functions of overexpressed and mutated cancer genes ( Calderwood and Gong, 2016 ). HSPs are associated with the outcomes of anticancer therapies, such as radiotherapy and immunotherapy in lung cancer patients ( Li et al, 2016 ; Das et al, 2019 ). They can facilitate protein folding and maintain protein structures that regulate cellular metabolisms, which are essential for cell survival and proliferation ( Chatterjee and Burns, 2017 ).…”