Peripheral hearing in Parkinson’s disease: a systematic review

Leme, Mariana S.; Sanches, Seisse Gabriela Gandolfi; Carvallo, Renata Mota Mamede

doi:10.1080/14992027.2022.2109073

Cited by 3 publications

(6 citation statements)

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“…11 In the same line, Moore et al, 52 using data from the UK Biobank study, observed that cognitive abilities decreased as SRTn increased; thus, HL could be a prodromal factor in the development of Alzheimer's disease, since people who develop dementia have accelerated deteriorations in cognitive performance up to 6 years earlier. 53 Regarding the association between SRTn and Parkinson's disease, Leme et al, 12 in a systematic review, observed that sensorineural HL and cochlear impairment are more severe in participants with Parkinson's disease, which is consistent with our findings. Hearing function is susceptible to neurochemical changes, which can be produced by neurodegenerative diseases that alter the integrity of the synaptic pathway and the neurotransmitters involved; thus, HL may be an early marker of the disease.…”

Section: Discussionsupporting

confidence: 91%

“…To our knowledge, this is the first study examining the association between hearing function and multimorbidity. Previous studies have examined the association between HL and some of the specific chronic diseases included in the definition of multimorbidity 10‐16 . For example, Sharma et al, 10 in a cross‐sectional analysis of the National Health and Nutrition Examination Survey (NHANES), observed that COPD was directly associated with HL.…”

Section: Discussionmentioning

confidence: 99%

“…Hearing loss (HL) is one of the most prevalent chronic diseases in older adults 9 . Some studies have associated HL with a higher prevalence of individual chronic diseases, including chronic obstructive pulmonary disease (COPD), dementia, Parkinson's disease, stroke, depression, osteoarthritis, coronary heart disease, and diabetes 10‐16 . Other studies have found that HL is also associated with impaired physical function, frailty, and disability 17‐21 .…”

mentioning

confidence: 99%

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Association Between Speech Reception Threshold in Noise and Multimorbidity: The UK Biobank Study

Yévenes‐Briones,

Caballero,

Struijk

et al. 2023

Otolaryngol.--head neck surg.

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ObjectiveTo investigate the association between hearing function, as approached with the functional auditory capacity, and multimorbidity.Study DesignCross‐sectional study.SettingThe UK Biobank was established from 2006 to 2010 in the United Kingdom. This cross‐sectional analysis included 165,524 participants who provided baseline information on hearing function.MethodsFunctional auditory capacity was measured with a digit triplet test. Three categories were defined according to the speech reception threshold in noise (SRTn): normal (SRTn < −5.5 dB signal‐to‐noise ratio [SNR]), insufficient (SRTn ≥ −5.5 to ≤ −3.5 dB SNR) and poor hearing function (SRTn > −3.5 dB SNR). To define multimorbidity, 9 chronic diseases were considered, including chronic obstructive pulmonary disease, dementia, Parkinson's disease, stroke, cancer, depression, osteoarthritis, coronary heart disease, and diabetes; multimorbidity was defined as the coexistence of 2 or more in the same individual. Analyses were conducted using logistic models adjusted for relevant confounders.ResultsAmong the study participants, 54.5% were women, and the mean (range) age was 56.7 (39‐72) years. The prevalence of insufficient and poor hearing function and multimorbidity was 13% and 13.2%, respectively. In comparison with having a normal SRTn, the odds ratio (95% confidence interval) of multimorbidity associated with insufficient SRTn was 1.13 (1.08‐1.18), and with poor SRTn was 1.25 (1.14‐1.37).ConclusionInsufficient and poor hearing function was associated with multimorbidity. This association suggests common biological pathways for many of the considered morbidities.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Association Between Speech Reception Threshold in Noise and Multimorbidity: The UK Biobank Study

Yévenes‐Briones,

Caballero,

Struijk

et al. 2023

Otolaryngol.--head neck surg.

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“…Several studies have shown that hearing impaired people suffer more frequently from PS [162,167]. In puretone audiometry, predominantly high-frequency losses [168][169][170][171] are found that exceed the extent of merely presbycusis [169,[172][173][174][175]. A British case-control study of 55 patients with PS and early onset ( ≤ 55 years) found unilateral or bilateral hearing thresholds deviating from the age norm in 64.7 % of patients and 28 % of the age-and sex-matched control group [169].…”

Section: Hearing Loss and Parkinson's Syndromementioning

confidence: 99%

“…Mehrere Studien konnten zeigen, dass Schwerhörige häufiger unter Parkinson leiden [162,167]. In der Tonaudiometrie findet man vorwiegend Hochtonverluste [168][169][170][171] die das Ausmaß einer reinen Presbyakusis überschreiten [169,[172][173][174][175]. Eine britische Fallkontrollstudie an 55 Patienten mit PS und frühem Erkrankungsbeginn ( ≤ 55 Jahre) fand bei 64,7 % der Patienten und 28 % der alters-und geschlechts-angepassten Kontrollgruppe ein-oder beidseitig von der Altersnorm abweichende Hörschwellen [169].…”

Section: Schwerhörigkeit Und Parkinsonunclassified

(Zu-)Hören mit alterndem Gehirn – eine kognitive Herausforderung

Großmann

2023

Laryngorhinootologie

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ZusammenfassungIn den letzten Jahren sind Hörstörungen als potentiell modifizierbarer Risikofaktor für neurokognitive Beeinträchtigungen der alternden Gesellschaft zunehmend in den Fokus wissenschaftlicher Arbeiten gerückt. Sensorische und kognitive Defizite sind über komplexe Bottom-Up und Top-Down Prozesse eng miteinander verbunden, eine scharfe Trennung von Sensorik, Wahrnehmung und Kognition ist unmöglich. Die Auswirkung normaler und pathologischer Alterungsprozesse sowohl des auditiven Systems als auch kognitiver Funktionen auf das Wahrnehmen und Verstehen von Sprache werden im Rahmen dieses Referates ebenso vorgestellt, wie die spezifischen auditorischen Beeinträchtigungen bei den beiden häufigsten neurodegenerativen Erkrankungen des älteren Menschen – Alzheimer-Krankheit und Parkinson-Syndrom. Hypothesen zum Kausalzusammenhang werden erläutert und der aktuelle Wissenstand zum Effekt der Hörrehabilitation aufgezeigt. Dieser Beitrag bietet damit einen Überblick über die komplexen Zusammenhänge von Hören und Kognition im höheren Lebensalter.

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Is Hearing Loss a Risk Factor for Idiopathic Parkinson’s Disease? An English Longitudinal Study of Ageing Analysis

Readman,

Wan,

Fairman

et al. 2023

Brain Sciences

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Observations that hearing loss is a substantial risk factor for dementia may be accounted for by a common pathology. Mitochondrial oxidative stress and alterations in α-synuclein pathology may be common pathology candidates. Crucially, these candidate pathologies are implicated in Parkinson’s disease (PD). Consequently, hearing loss may be a risk factor for PD. Subsequently, this prospective cohort study of the English Longitudinal Study of Ageing examines whether hearing loss is a risk factor for PD longitudinally. Participants reporting self-reported hearing capabilities and no PD diagnosis prior to entry (n = 14,340) were used. A joint longitudinal and survival model showed that during a median follow up of 10 years (SD = 4.67 years) increased PD risk (p < 0.001), but not self-reported hearing capability (p = 0.402). Additionally, an exploratory binary logistic regression modelling the influence of hearing loss identified using a screening test (n = 4812) on incident PD indicated that neither moderate (p = 0.794), nor moderately severe/severe hearing loss (p = 0.5210), increased PD risk, compared with normal hearing. Whilst discrepancies with prior literature may suggest a neurological link between hearing loss and PD, further large-scale analyses using clinically derived hearing loss are needed.

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Peripheral hearing in Parkinson’s disease: a systematic review

Cited by 3 publications

References 55 publications

Association Between Speech Reception Threshold in Noise and Multimorbidity: The UK Biobank Study

Association Between Speech Reception Threshold in Noise and Multimorbidity: The UK Biobank Study

(Zu-)Hören mit alterndem Gehirn – eine kognitive Herausforderung

Is Hearing Loss a Risk Factor for Idiopathic Parkinson’s Disease? An English Longitudinal Study of Ageing Analysis

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