Peripheral endothelial function and arterial stiffness in women with migraine with aura: a case-control study

Liman, Thomas; Neeb, Lars; Rosinski, Jana; Wellwood, Ian; Reuter, Uwe; Doehner, Wolfram; Heuschmann, PU; Endres, Matthias

doi:10.1177/0333102412444014

Cited by 36 publications

(73 citation statements)

References 48 publications

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“…Seven studies measured IMT in migraine patients with conflicting results (9,(23)(24)(25)(26)(27). Comparison between these studies is hampered by different case selection methods, such as clinic based (23,(25)(26)(27)(28) versus population based (9,24), and exclusion of participants with known cardiovascular risk factors (23,(25)(26)(27)(28) versus correction for these risk factors (9,24). The two largest population-based studies (9,24), with more than 100 migraine patients (unselected with regard to cardiovascular risk factors), found slightly decreased values of IMT, which is in line with our findings.…”

Section: Discussionmentioning

confidence: 99%

Migraine is not associated with enhanced atherosclerosis

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Migraine is not associated with enhanced atherosclerosis

et al. 2012

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“…Several among the available studies did not reveal any alteration in the endothelial function of migraineurs. Six of them did not find any difference in FMD between migraineurs and control subjects (Table 2) [20-23,25,26] and a further study confirmed the lack of any alteration in endothelial function assessed by PAT ratio (Table 3) [32]. Three studies assessing peripheral vasodilation after pharmacological stimuli found comparable responses in subjects with and without migraine (Table 3) [20,33,35].…”

Section: Reviewmentioning

confidence: 92%

“…Most of them assessed endothelial function by measuring FMD (Table 2) [20-30], some used PAT (Table 3) [31,32], some measured peripheral vasodilation in response to pharmacological stimuli (Table 3) [20,30,33-35], and others assessed endothelial progenitor cells (EPCs) (Table 4) [23,36,37]. Findings were not consistent across the studies.…”

Section: Reviewmentioning

confidence: 99%

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Peripheral vascular dysfunction in migraine: a review

et al. 2013

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Numerous studies have indicated an increased risk of vascular disease among migraineurs. Alterations in endothelial and arterial function, which predispose to atherosclerosis and cardiovascular diseases, have been suggested as an important link between migraine and vascular disease. However, the available evidence is inconsistent. We aimed to review and summarize the published evidence about the peripheral vascular dysfunction of migraineurs.We systematically searched in BIOSIS, the Cochrane database, Embase, Google scholar, ISI Web of Science, and Medline to identify articles, published up to April 2013, evaluating the endothelial and arterial function of migraineurs.Several lines of evidence for vascular dysfunction were reported in migraineurs. Findings regarding endothelial function are particularly controversial since studies variously indicated the presence of endothelial dysfunction in migraineurs, the absence of any difference in endothelial function between migraineurs and non-migraineurs, and even an enhanced endothelial function in migraineurs. Reports on arterial function are more consistent and suggest that functional properties of large arteries are altered in migraineurs.Peripheral vascular function, particularly arterial function, is a promising non-invasive indicator of the vascular health of subjects with migraine. However, further targeted research is needed to understand whether altered arterial function explains the increased risk of vascular disease among patients with migraine.

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“…Liman et al indicated that there was no significant difference in CAIMT and peripheral arterial tonometry (PAT) ratio in female patients with migraine with aura. [18] They concluded that in women with migraine with aura, peripheral endothelial function is not disturbed, but they have increased arterial stiffness that may explain increased stroke incidence in this population. Schwaiger et al investigated both burden of atherosclerosis via carotid and femoral artery IMT measurement, and venous thromboembolism incidence in migraine patients compared to non-migrainous participants.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Subclinical Atherosclerosis in Migraine Patients by Ultrasound Radiofrequency-Data Technology, Preliminary Results

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et al. 2016

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SummaryObjectives: Migraine is a headache disorder affecting approximately 12% of the population, predominantly female individuals. Migraine has been associated with vascular events such as stroke and cardiovascular disease. The close connection between these vascular disorders and atherosclerosis is well known. Carotid artery intima-media thickness (CAIMT) is a marker for detection of subclinical atherosclerosis. The present study is an analysis of the presence of subclinical atherosclerosis in migraine patients. Methods: CAIMT was evaluated in 25 female migraine patients and 27 female controls using innovative ultrasound (US) radiofrequency (RF) data technology. Mann-Whitney U test was used to compare measurements in patient and control groups. Results: There was a statistically significant difference between mean CAIMT of migraine patients and control group (p<0.005): mean CAIMT was 701±114 μm in migraine patients and 400±64 μm in control group. Conclusion: Migraine patients are more prone to atherosclerosis compared to healthy individuals. CAIMT measurement with sonography can be utilized in follow-up to detect subclinical atherosclerosis.Keywords: Carotid; intima-media thickness; migraine; ultrasound radiofrequency data technology. ÖzetAmaç: Migren, toplumun yaklaşık %12'sini ve ağırlıklı olarak da kadın bireyleri etkileyen bir baş ağrısı bozukluğudur. Migren, inme ve kalp-damar hastalığı gibi vasküler patolojiler ile ilişkilendirilmiştir. Bu vasküler bozukluklar ile ateroskleroz arasındaki yakın bağlantı iyi bilinmektedir. Karotis arter intima media kalınlığı, subklinik aterosklerozun saptanması için bir göstergedir. Biz bu çalışmada; migren hastalarında subklinik aterosklerozun varlığını incelemeyi amaçladık. Gereç ve Yöntem: Karotis arter intima media kalınlığı, 25 kadın migren hastasında ve 27 kadın kontrol grubunda yeni bir teknik olan ultrason radyofrekans-veri teknolojisi ile değerlendirildi. Hasta ve kontrol gruplarında fark varlığını analiz etmek için Mann-Whitney U testi kullanıldı. Bulgular: Migren hastaları ve kontrol grubu arasında ortalama karotis intima media kalınlığı açısından istatistiksel olarak anlamlı fark saptandı (p<0.005). Ortalama karotis intima media kalınlığı migren hastalarında 701±114 mikrometre iken kontrol grubunda 400±64 mikrometre ölçüldü. Sonuç: Migren hastaları, sağlıklı bireylere oranla ateroskleroza daha yatkındır. Sonografi ile karotis arter intima media kalınlığı ölçümü bu hastalarda subklinik aterosklerozun tanınması amacıyla takiplerde kullanılabilir.Anahtar sözcükler: Karotis; intima media kalınlık; migren; ultrason radyofrekans-veri analizi.

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Peripheral endothelial function and arterial stiffness in women with migraine with aura: a case-control study

Abstract: Peripheral endothelial function is not impaired in women with MA, but they have greater arterial stiffness. This may contribute to the increased stroke risk in women with MA.

Cited by 36 publications

References 48 publications

Migraine is not associated with enhanced atherosclerosis

Migraine is not associated with enhanced atherosclerosis

Peripheral vascular dysfunction in migraine: a review

Evaluation of Subclinical Atherosclerosis in Migraine Patients by Ultrasound Radiofrequency-Data Technology, Preliminary Results

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