Peripheral edema and oral acyclovir

Hisler, Barbara M.; Daneshvar, Saeed A.; Aronson, Peter J.; Hashimoto, Ken

doi:10.1016/s0190-9622(88)80025-2

Cited by 7 publications

(1 citation statement)

References 2 publications

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“…Cutaneous reactions secondary to oral administration of aciclovir are uncommon. A review of the literature, however, reveals that vesicular dermatitis, 1,2 dermatitis involving the palms and soles, 3 peripheral oedema, 4,5 erythema nodosum, 6 exanthems, 3,6–8 hyperphydrosis, 9 acne, 9 lichenoid eruption, 3 pruritus, 10 rash, 7 urticaria, 3,6 , 11,12 vasculitis, 6 and alopecia 9 have been described after orally administered aciclovir.…”

Section: Reportmentioning

confidence: 99%

Drug eruption secondary to aciclovir with recall phenomenon in a dermatome previously affected by herpes zoster

Carrasco¹,

Pastor²,

Izquierdo³

et al. 2002

Clinical and Experimental Dermatology

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Classically, recall dermatitis refers to chemotherapy-induced reactivation of skin damage caused by radiotherapy months, or even years, earlier. The concept of recall dermatitis has now been extended to include radiation recall dermatitis induced by other drugs, ultraviolet radiation, extravasation of drugs, and allergic contact dermatitis. We now describe recall dermatitis along the residual cutaneous lesions of a previous thoracic herpes zoster in a patient who developed a drug eruption after oral administration of aciclovir. The most striking feature consisted of confluent linear erythema along the dermatomes previously involved by the herpes zoster episode. Histopathologic study demonstrated small foci of spongiosis, vacuolar changes involving the basal layer of the epidermis and single necrotic keratinocytes scattered within the epidermis. The papillary dermis appeared oedematous and with dilated blood capillaries surrounded by a sparse inflammatory infiltrate composed mainly of lymphocytes. Serial sections failed to demonstrate cytologic changes of herpes varicella zoster infection. We interpreted this case as an example of recall dermatitis because the widespread cutaneous eruption secondary to aciclovir was more intense in skin previously compromised by herpes varicella zoster infection. To the best of our knowledge, recall dermatitis has not been described before at the site of previous involvement by herpes zoster.

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