Peripheral Distribution of Forelimb Nerves in Amblystoma

Thompson, J. D.

doi:10.1126/science.84.2179.310

Cited by 4 publications

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The nervous system and regeneration of the forelimb of adult triturus. VI. A further study of the importance of nerve number, including quantitative measurements of limb innervation

Singer¹

1947

J. Exp. Zool.

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As has been shown repeatedly in the past, denervation of the amputation stump of the urodele limb successfully prevents subsequent regeneration. This fact has l e d l o a number of studies of the relation of the nerve to the regeneration process. Notable among these has been the analysis of the action of the individual nerve components in the influence of the nerve on regeneration (see Singer, '42-'46 for review). In a series of studies of which the present paper is the sixth, the problem of the activity of the individual nerve components has been reanalyzed (Singer, loc. cit.). The results which have emerged from these investigations permit a revaluation of our views on the relation of nervous activity to the regeneration process as observed in amphibians. Of the 3 nerve components (sensory, motor and sympathetic) which supply the forelimb, only the sensory is capable of stimulating regeneration in the absence of the other 2. The effectiveness of the sensory component does not appear to be due to a special quality of its fibers not enjoyed by other neural elements, but rather to a quantitative superiority. The anatomy of the peripheral nervous system favors the sensory component, 223

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