Peripheral Dentinogenic Ghost Cell Tumor

Abstract

Peripheral dentinogenic ghost cell tumor is a rare tumor with only 24 cases previously described in the English literature. The majority of cases have been reported to occur in the anterior part of the jaws. A case occurring in posterior (molar region) of the mandible in a 75-year-old edentulous woman is reported. The patient presented with a nodular swelling in the left mandible that showed erosion (saucerization) of the underlying bone radiographically. On microscopy, the tumor showed mainly solid epithelial islands resembling ameloblastoma in fibrous connective tissue. The islands were associated with ghost cells and dysplastic dentin. This report includes the clinical, radiographic, and microscopic features of the patient, in addition to the review of the English literature on the tumor.

Peripheral Dentinogenic Ghost Cell Tumor: A Rare Odontogenic Entity Hidden within the Ordinary Clinical Features of Reactive Gingival Lesions

“…However, it was unknown if the cover mucosa ulceration was related to a secondary trauma or not; thus the role of chronic irritation cannot be totally excluded. The connection between the basal cells of the overlying oral mucosa epithelium and the tumor epithelial islands has been suggested that may be involved in the histogenesis of the PDGCT [9]. This finding was not observed in our case.…”

“…The exact etiologic factors involved in the development of this tumor remain elusive. Trauma or/and chronic irritation may be considered as predisposing factor, since 7 cases of PDGCT have been described in edentulous alveolar ridge in denture wearers [9,10,11], whereas a PDGCT case has been reported in the maxillary gingiva at tooth extraction site [12]. In our patient, a local predisposing factor was not evident.…”

“…Clinically, the PDGCT presents as a swelling with the canine till first molar area to be more frequent and a certain predilection for the mandible. The maxillary location of the PDGCT is referred in a percentage of 26% [9]. The majority of patients report no pain or mild discomfort as a symptom [4,5].…”

Intraosseous and Extraosseous Variants of Dentinogenic Ghost Cell Tumor: Two Case Reports

“…The extraosseous DGCT is apparently rare so it is difficult to typify the age, sex and location distribution. Though according to existing literature knowledge it appears to be slightly more common in the mandible than the maxilla, with a predilection for the elderly age group ( 7 , 8 ). In our case, the relatively different feature was patient age, 15-year-old.…”

“…In our case, the relatively different feature was patient age, 15-year-old. The mean age of the previously reported cases was 59 years old ( 7 ).…”