Intraosseous and Extraosseous Variants of Dentinogenic Ghost Cell Tumor: Two Case Reports

Tekkeşın, Merva Soluk; Erdem, Mehmet Ali; Özer, Nedim; Olgaç, Vakur

doi:10.17096/jiufd.38386

Cited by 7 publications

(7 citation statements)

References 11 publications

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“…Amounting to the presence and extent of calcification, DGCT may appear radiographically as radiolucent, radiopaque or mixed lesion. Lesions can be unilocular or multilocular with either welldefined or ill-demarcated margins[17]. These findings were in accordance with the literature review carried out by Konstantakis et al[15] in 2013.…”

Section: Discussionsupporting

confidence: 84%

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Dentinogenic ghost cell tumor: A case report

Patankar

Khetan

Choudhari

et al. 2019

WJCO

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BACKGROUND Dentinogenic ghost cell tumor (DGCT) is an uncommon locally invasive odontogenic neoplasm. It is considered to be a solid variant of calcifying odontogenic cyst (COC). This tumor makes up for only 2%-14% of all COCs and less than 0.5% of all odontogenic tumors which owes to its rarity. The purpose of this paper was to describe a case of DGCT and the treatment adopted in our case, and to provide a review of this case in the indexed literature. CASE SUMMARY In this article, we discussed a case of 18 year old male who reported with a chief complaint of a recurrent swelling and dull aching pain in upper left back region of the jaw. Computed tomography scan was carried out which revealed hypodense lesion with a few hyperdense flecks within it suggesting the presence of calcification. On incisional biopsy, diagnosis of COC was given. After segmental resection of the lesion, histopathogically odontogenic epithelium was noted along with calcifications, ghost cells and dentinoid material. Special staining was done with van Gieson and it showed pink areas of dentinoid material and yellow colour represented ghost cells. Hence, amalgamation of careful clinical examination, use of advanced radiographic imaging and detailed histopathological examination confirmed the diagnosis of DGCT. The patient was followed up for one year and there was no recurrence of the lesion or signs of any residual tumor. CONCLUSION Radical treatment should be carried out along with mandatory long-term follow up in order to avoid recurrence in aggressive lesions.

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Section: Discussionsupporting

confidence: 84%

“…It was stated by Soluk Tekkesin et al[17] that intraosseous DGCTs are more aggressive than their extraosseous counterparts. More aggressive local resection is recommended for intraosseous variant, particularly if the tumor is radiologically ill-defined.…”

Section: Discussionmentioning

confidence: 99%

Dentinogenic ghost cell tumor: A case report

Patankar

Khetan

Choudhari

et al. 2019

WJCO

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“…It could be unilocular or multilocular with a well-defined or ill-demarcated margins. Root resorption, displacement of adjacent teeth, and the presence of impacted teeth have been noted [ 12 – 14 ]. In the present case, the recurrence was presented as well-demarcated radiolucency causing disruption of the inferior maxillary sinus wall and resorption of the molar teeth roots, suggesting the aggressive nature of the tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Intraosseous DGCT can have an infiltrative growth pattern and can recur after treatment [ 3 ]. Intraosseous variants of DGCT are more aggressive than extraosseous variants [ 14 ]. Aggressive local resection with adequate safety margins is advised for the intraosseous variants [ 14 , 15 ], especially in cases of ill-defined margins radiologically [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…Intraosseous variants of DGCT are more aggressive than extraosseous variants [ 14 ]. Aggressive local resection with adequate safety margins is advised for the intraosseous variants [ 14 , 15 ], especially in cases of ill-defined margins radiologically [ 1 ]. Complete removal of the tumor could necessitate a block excision, segmental mandibular resection, or partial maxillectomy [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

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Recurrent Dentinogenic Ghost Cell Tumor: A Case Report

et al. 2022

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Patient: Male, 42-year-old Final Diagnosis: Dentinogenic ghost cell tumor Symptoms: Swelling • recurrent pain Medication: — Clinical Procedure: Segmental maxillectomy Specialty: Dentistry • Pathology • Surgery Objective: Rare disease Background: Dentinogenic ghost cell tumor (DGCT) is a rare, locally invasive odontogenic neoplasm, considered as a solid variant of the calcifying odontogenic cyst (COC). DGCT accounts for only 2% to 14% of all COCs and less than 0.5% of all odontogenic tumors. It is characterized by an ameloblastomatous odontogenic epithelium and the presence of ghost cells and dentinoid material. Case Report: A 42-year-old male patient presented to the clinic with recurrent pain and swelling in the left maxilla. The patient had a similar presentation 3 years before, which had been managed by excisional biopsy and was misdiagnosed as unicystic ameloblastoma. Examination revealed a mild swelling in the left cheek with boney expansion on the posterior area of the left maxilla, with mobility in adjacent teeth. Radiographic evaluation revealed a large, well-demarcated radiolucent lesion with a sclerotic border involving the left maxilla and associated with root resorption in the adjacent teeth. An incisional biopsy was performed, and a diagnosis of DGCT was made. Segmental maxillectomy with safe margins was conducted, considering the aggressiveness of this pathological entity. The defect was reconstructed using the buccal fat pad. Histopathology examination confirmed the diagnosis of DGCT, which was characterized by ameloblastomatous odontogenic epithelium, dentinoid material, and ghost cells. One month follow-up revealed good healing of the surgical site. The patient was scheduled for regular follow-up. Conclusions: This case reports the aggressiveness and high recurrence rates of DGCT. It is recommended to treat DGCT aggressively with safe margins and a long-term follow-up.

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Comparative Analysis Between Dentinogenic Ghost Cell Tumor and Ghost Cell Odontogenic Carcinoma: A Systematic Review

Vieira

Montovani

Rozza-De-Menezes

et al. 2021

Head and Neck Pathol

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Dentinogenic ghost cell tumor (DGCT) and ghost cell odontogenic carcinoma (GCOC) form a spectrum of rare benign and malignant odontogenic neoplasms, respectively. The aim of this study was to perform a comparative systematic review of the clinicopathological, genetic, therapeutic, and prognostic features of DGCT and GCOC. The electronic search was performed until December 2020 on seven electronic databases. Case reports, series, and research studies with enough histopathological criteria for diagnosis and all genomic studies were included. Both DGCT and GCOC showed a male prevalence (p = 0.043), with mandibular and maxillary predilections, respectively (p = 0.008). Peripheral DGCT (DGCTp) affected most elderly people (p < 0.001), and central DGCT (DGCTc) and GCOC occurred mainly in younger individuals. Unilateral enlargement of maxilla or mandible was the most common clinical sign associated with a radiolucent or mixed image. Ameloblastomatous epithelium was often present in both neoplasms. Basaloid and large cells with vesicular nuclei were also frequently seen in GCOC. β-catenin expression and mutations (CTNNB1 gene) were found in DGCT and GCOC. Conservative surgery was mostly used for DGCTp, while radical resection was chosen for DGCTc and GCOC. High recurrence rates were found in DGCTc and GCOC. Metastasis occurred in 16.7% of GCOC cases and the 5-year survival rate was 72.6%. DGCT and GCOC share numerous clinicopathological features and demand a careful histopathological evaluation, considering the overlap features with other odontogenic tumors and the possibility of malignant transformation of DGCT. A strict regular post-operative follow-up is mandatory due to high recurrence rates and metastatic capacity in GCOC.

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Intraosseous and Extraosseous Variants of Dentinogenic Ghost Cell Tumor: Two Case Reports

Cited by 7 publications

References 11 publications

Dentinogenic ghost cell tumor: A case report

Dentinogenic ghost cell tumor: A case report

Recurrent Dentinogenic Ghost Cell Tumor: A Case Report

Comparative Analysis Between Dentinogenic Ghost Cell Tumor and Ghost Cell Odontogenic Carcinoma: A Systematic Review

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