Peripheral blood neutrophil-to-lymphocyte ratio in preterm infants with intraventricular hemorrhage

Stein, Alan; Eyerly-Webb, Stephanie; Solomon, Rachele; Tani, Christine; Shachar, Elad; Kimball, Rebekah; Hertzler, Dean A.; Spader, Heather S.

doi:10.1016/j.clineuro.2019.03.012

Cited by 12 publications

(15 citation statements)

References 29 publications

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“…Our results showed statistically significant difference regarding NLR at time of IVH and at time of seizure with P value <0.001. This was in agreement with Stein et al, [8] who study Peripheral blood neutrophil-to-lymphocyte ratio in preterm infants with intraventricular hemorrhage. study included premature infants with IVH and a neonatal reservoir placed between January 2013 and January 2018.…”

Section: Discussionsupporting

confidence: 93%

“…Stein et al, [8] confirmed utility of NLR for predicting outcomes after neurologic injury in the pediatric population, especially in preterm infants. In this study population, a greater NLR was observed in patients with an increased risk of seizures.…”

Section: Discussionmentioning

confidence: 94%

“…Preterm infants (from 28 week to 34 week EGA) with IVH with criteria of diagnoses including [8] :  Maternal medical history of any acute or chronic illness before or during pregnancy)…”

Section: The Inclusion Criteriamentioning

confidence: 99%

“…NLR measured from a peripheral blood complete blood count (CBC) provides a simple, costeffective index of inflammation [8].…”

Section: Introductionmentioning

confidence: 99%

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Peripheral Neutrophil- Lymphocyte Ratio as a Predictor of Seizure in Preterm Infants with Intra-Ventricular Hemorrhage

Ashraf

El-Sheikh

El-Mashad

2021

AJPR

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Background: Preterm infants with Intra-Ventricular Hemorrhage (IVH) are at risk for developing significant complications, including post hemorrhagic hydrocephalus and seizures. Neonatal seizures are the most common overt manifestation of neurological dysfunction in the newborn, and is associated with short- and long-term adverse effects. Objective: The aim of the study is to evaluate the value of Peripheral Neutrophil- lymphocyte ratio (NLR) as a predictor of seizure in preterm infants with intra-ventricular hemorrhage. Methods: This prospective cohort study that comprised 60 Preterm infants with IVH admitted at NICU pediatric department Tanta university hospital from November 2019 to May 2020, Preterm infants were divided into two groups according to incidence of seizure. Preterm infants in this study subjected to Careful history taking, clinical examination and investigations (laboratory and Trans-cranial ultrasound) as well as analysis of result and follow up clinical status for development of seizure. Results: There was a statistically highly significant difference regarding NLR and development of seizure with p value <0.001 (NLR ≥ 2.3 with sensitivity 96%, specificity 93%, Area under the curve 0.849 and accuracy 84.9%). Conclusion: NLR is a predictor of seizure in preterm infants with intra-ventricular hemorrhage.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 94%

“…Preterm infants (from 28 week to 34 week EGA) with IVH with criteria of diagnoses including [8] :  Maternal medical history of any acute or chronic illness before or during pregnancy)…”

Section: The Inclusion Criteriamentioning

confidence: 99%

“…NLR measured from a peripheral blood complete blood count (CBC) provides a simple, costeffective index of inflammation [8].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Peripheral Neutrophil- Lymphocyte Ratio as a Predictor of Seizure in Preterm Infants with Intra-Ventricular Hemorrhage

Ashraf

El-Sheikh

El-Mashad

2021

AJPR

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“…Different types of blood cells play an important role in inflammation and associated morbidities in preterm infants. Hematological parameters have been investigated as indicators of increased inflammatory response in morbidities, such as bronchopulmonary dysplasia, patent ductud arteriosus, and intraventricular hemorrhage of very preterm infants [7,28,29]. However, the association between hematologic parameters and ratios at birth and the risk of ROP in very premature infants remains elusive.…”

Section: Introductionmentioning

confidence: 99%

Can Hematological Parameters be a Indicator Risk Factor in the Development of Retinopathy of Prematurity?

et al. 2020

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Background Hematological parameters have been investigated as being indicative of increased inflammatory response in morbidity of very preterm infants. This study aims to determine whether the hematologic parameters and ratios of preterms can be an indicative risk factor for the development of retinopathy of prematurity (ROP). Materials-Methods This retrospective cohort study examined newborns born before 32 weeks. Twenty-three patients treated with the diagnosis of ROP were included in the patient group. The control group included 23 patients who did not have ROP (no-ROP). Medical records of eligible preterm infants were retrospectively reviewed. Hemogram samples obtained from all patients during the first 24 h of life and samples of their mothers obtained before delivery were evaluated. The hemogram parameters of white blood cell (WBC) count, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, lymphocyte/monocyte ratio, and platelet mass index were calculated. Results No difference was observed between the groups in terms of demographic data. In terms of hematological parameters, maternal WBC counts of ROP patients were significantly higher than those of no-ROP patients and WBC counts of ROP patients were significantly lower than those of no-ROP patients. Conclusions This study found that high WBC counts in mothers before delivery and/or low WBC counts in preterms during the first postnatal day were higher in developed ROP. These results could lead to the development of prospective studies to assess the real prognostic value of WBC in ROP.

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Pathophysiologic mechanisms and strategies for the treatment of post-hemorrhagic hydrocephalus of prematurity

et al. 2022

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Peripheral blood neutrophil-to-lymphocyte ratio in preterm infants with intraventricular hemorrhage

Cited by 12 publications

References 29 publications

Peripheral Neutrophil- Lymphocyte Ratio as a Predictor of Seizure in Preterm Infants with Intra-Ventricular Hemorrhage

Peripheral Neutrophil- Lymphocyte Ratio as a Predictor of Seizure in Preterm Infants with Intra-Ventricular Hemorrhage

Can Hematological Parameters be a Indicator Risk Factor in the Development of Retinopathy of Prematurity?

Pathophysiologic mechanisms and strategies for the treatment of post-hemorrhagic hydrocephalus of prematurity

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