Peripheral blood lymphocytes and selected serum interleukins in workers operating X-ray equipment

Hrycek, A; Czernecka-Micińska, Aleksandra; Kłuciński, Piotr; Badowski, R

doi:10.1016/s0378-4274(02)00030-9

Cited by 17 publications

(10 citation statements)

References 12 publications

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“…Long-term exposure of MPs to low dose radiation has been observed by examining its effect on hematopoietic system. The effect of radiation on hematopoietic and immune system (Hrycek, Czernecka-Micińska, Kłuciński, & Badowski, 2002;Radiation, 2012) suggest that, long-term effects can disturb immunity of medical professionals by suppressing or stimulating the immune system and may induce various hematological diseases (Andreassi et al, 2005;Roguin, Goldstein, & Bar, 2012;Venneri et al, 2009). As shown by Table 1, our results demonstrated that most of the hematological parameters remained within the normal range.…”

Section: Discussionmentioning

confidence: 50%

Hematological Findings in Medical Professionals Involved at Intraoperative Fluoroscopy

Shafiee¹,

Hoseinnezhad²,

Vafapour³

et al. 2016

GJHS

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Medical professionals involved at intraoperative fluoroscopy are exposed to low doses of the occupational radiation exposures. The biological effects of chronic low-dose radiation on human health are complex and have not been well established. The aim of the present study is to follow up hematological parameter changes during 2 years in medical professionals exposed to ionization radiation in operating rooms.22 medical professionals (medical specialists and technicians), chronically exposed to ionizing radiation of mobile C-Arm X ray machine, were selected. The seven hematological parameters were examined each time. The statistical analyses were done by Student’s t test and one way ONOVA test.The data analysis led to the following observations: (1) the present study incorporated that the basic hematological parameters including the mean value of red blood cells (P=0.90), white blood cells (P=0.68), and platelets count (P=0.45) did not show a significant difference between two years. (2) The mean values corpuscular hemoglobin concentration, corpuscular hemoglobin, and hematocrit parameters were found disturbed low or high in some of medical professionals but their means were not significantly different between two measurements. (3)A statistically significant relation in mean value of RBCs with the duration of exposure and sex were observed.It seems that, hematological parameters survey could not be a reliable test as the biological indicator of long term exposure to very low dose of radiation exposure in medical professionals which their physical dosimetry values are lower than dose limits.

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Section: Discussionmentioning

confidence: 50%

Hematological Findings in Medical Professionals Involved at Intraoperative Fluoroscopy

Shafiee¹,

Hoseinnezhad²,

Vafapour³

et al. 2016

GJHS

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“…A growing body of evidence indicates immunological changes induced by exposure to ionizing radiation. The effect of ionizing radiation on selected indices of cellular and humoral immunities in workers occupationally exposed to low levels of ionizing radiation has been studied [13,14]. Cluster of differentiation (CD)4(+) T-lymphocytes and humoral immune response levels were found to be significantly lower in radiation exposed workers compared to control group [13].…”

Section: Introductionmentioning

confidence: 99%

Healthcare Workers Occupationally Exposed to Ionizing Radiation Exhibit Altered Levels of Inflammatory Cytokines and Redox Parameters

Ahmad

Abdalla²,

Moore³

et al. 2019

Antioxidants

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Studies have shown an increased risk for a variety of cancers, specifically brain cancer, in healthcare workers occupationally exposed to ionizing radiation. Although the mechanisms mediating these phenomena are not fully understood, ionizing radiation-mediated elevated levels of reactive oxygen species (ROS), oxidative DNA damage, and immune modulation are likely involved. A group of 20 radiation exposed workers and 40 sex- and age-matched non-exposed control subjects were recruited for the study. We measured superoxide (O2•−) levels in whole blood of healthcare workers and all other measurements of cytokines, oxidative DNA damage, extracellular superoxide dismutase (EcSOD) activity and reduced/oxidized glutathione ratio (GSH/GSSG) in plasma. Levels of O2•− were significantly higher in radiation exposed workers compared to control. Similarly, a significant increase in the levels of interleukin (IL)-6, IL-1α and macrophage inflammatory protein (MIP)-1α in radiation exposed workers compared to control was observed, while there was no significance difference in the other 27 screened cytokines. A significant positive correlation was found between MIP-1α and O2•− levels with no correlation in either IL-6 or IL-1α. Further, a dose-dependent relationship with significant O2•− production and immune alterations in radiation exposed workers was demonstrated. There was no statistical difference between the groups in terms of oxidative DNA damage, GSH/GSSG levels, or EcSOD activity. Although the biologic significance of cytokines alterations in radiation exposed workers is unclear, further studies are needed for determining the underlying mechanism of their elevation.

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“…As well, previous studies showed that serum concentration of C-reactive protein (CRP), interleukin-1β, TNF-α, IL-6 showed only slightly higher increase in X-ray department workers compared with control group (Hrycek et al,2002 ).…”

Section: Discussionmentioning

confidence: 52%

Radio-adaptive Response: An Implication for the Biological Consequences of Low Dose-rate Exposure to X-Ray

2014

Egypt. J. Rad.Sci.

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ADIATION induced adaptive response is described as the reduced damaging effect of a challenging radiation dose when induced by a previous low priming dose. To verify the radio-adaptive response that can be induced by occupationally (in vivo) received chronic low dose of X-ray, chromosomal aberration (CA) analysis, micronucleus test (MN), interleukin-1β (IL-1β) and nitric oxide (NO) concentrations were investigated for both the occupationally exposed and control groups before and after exposure to 2 Gy γ-rays as a challenge dose.The results showed that an elevated frequency of CA, MN and nucleoplasmic bridge (NPB) was recorded in radiation workers (exposed group) compared to control group. However, after 2Gy in vitro irradiation of lymphocytes of exposed and control groups, the exposed group was found to be lower than that of control group.On the other hand, IL-1β and NO concentrations in plasma were elevated in exposed group more than in control group. While, after 2Gy irradiation for both groups, there are higher increment in the concentrations of IL-1β and NO in exposed group than the increment difference observed for control group after in vitro irradiation as compared to the same group before irradiation.The present results suggested the existence of an in vivo cytogenetic adaptive response in individuals occupationally exposed to low dose of X-ray. In addition, the results showed that NO radicals and IL-1β have a role in the induction of radio-resistance due to in vivo exposure that may intermediate this radiation.

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Peripheral blood lymphocytes and selected serum interleukins in workers operating X-ray equipment

Cited by 17 publications

References 12 publications

Hematological Findings in Medical Professionals Involved at Intraoperative Fluoroscopy

Hematological Findings in Medical Professionals Involved at Intraoperative Fluoroscopy

Healthcare Workers Occupationally Exposed to Ionizing Radiation Exhibit Altered Levels of Inflammatory Cytokines and Redox Parameters

Radio-adaptive Response: An Implication for the Biological Consequences of Low Dose-rate Exposure to X-Ray

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