Peripheral blood CD38 expression predicts survival in B-cell chronic lymphocytic leukemia

Morabito, Fortunato; Mangiola, Massimo; Oliva, Bianca; Stelitano, Caterina; Callea, Vincenzo; Deaglio, Silvia; Iacopino, Pasquale; Brugiatelli, Maura; Malavasi, Fabio

doi:10.1016/s0145-2126(01)00049-2

Cited by 44 publications

(28 citation statements)

References 34 publications

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“…The absence of somatic mutations in the immunoglobulin V H genes (Damle et al, 1999;Hamblin et al, 1999), high levels of cell surface CD38 (Damle et al, 1999;Morabito et al, 2001;Hamblin et al, 2002) and presence of Zap70 (Rosenwald et al, 2001, Crespo et al, 2003, Wiestner et al, 2003 are associated with a poor prognosis. Although there was a tendency for higher levels of apoptosis in CLL lacking V H mutations (U-CLL) compared to CLL with mutated V H genes (M-CLL) for both inhibitors (mean PARP cleavage for U-CLL and M-CLL cells for BAY was 41 and 28%, mean PARP cleavage for U-CLL and M-CLL cells for KA was 37 and 23%), there was considerable overlap in the levels of PARP cleavage in individual cases within these two groups and these differences were not statistically significant (P>0.05; Student's t-test).…”

Section: Resultsmentioning

confidence: 99%

Pharmacological inhibitors of NF-κB accelerate apoptosis in chronic lymphocytic leukaemia cells

et al. 2006

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Section: Resultsmentioning

confidence: 99%

Pharmacological inhibitors of NF-κB accelerate apoptosis in chronic lymphocytic leukaemia cells

et al. 2006

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“…There is a high degree of variation in the clinical course with some patients remaining asymptomatic for many years whilst others rapidly require treatment. A number of molecular markers including cytogenetics abnormalities, 1 immunoglobulin gene mutational status, 2,3 ZAP-70 expression 4,5 and CD38 expression [6][7][8] allow the prognosis of asymptomatic patients to be predicted. The regulation of expression and functions of these prognostic markers must be related, either directly or indirectly, to the clinical evolution of CLL and this relation is currently being intensively investigated.…”

mentioning

confidence: 99%

Regulation of CD38 in proliferating chronic lymphocytic leukemia cells stimulated with CD154 and interleukin-4

Willimott¹,

Baou²,

Huf³

et al. 2007

Haematologica

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“…45 It was also proposed that presence of CD38 expression was associated with other markers of poor prognosis in CLL, namely, ZAP70, cytogenetic anomalies, serum CD23, serum β2 microglobulin, p53 function and cell size. 46 Domingo-Domenech et al found that patients displaying CD38 positivity needed treatment more frequently compared to those without CD38 expression.…”

Section: 35mentioning

confidence: 99%

“…45 Determining CD38 and ZAP70 expressions is quicker and cheaper compared to IgVH mutation. Some reports showed that analysis of ZAP70 and CD38 si-…”

mentioning

confidence: 99%

Prognostic Significance of the IgVH Mutation Status and Immunohistochemical Analysis of ZAP70 and CD38 in Bone Marrow Biopsies in Chronic Lymphocytic Leukemia

Çetin¹,

Döger²,

Kurtgöz³

et al. 2014

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Chronic lymphocytic leukemia (CLL) is one of the most common leukemia type among adults in the industrialized countries. Due to the nature of CLL, it is important to recognize patients with a more rapid course of disease. The goal of our study was to study ZAP70 and CD38 antibodies along with immunglobulin heavy chain variable region (IgVH) mutation status, which have been associated with rapid progression and aggressive clinical course in CLL, and to correlate the expression of these molecules with patterns of bone marrow infiltration. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : We included 84 bone marrow biopsy samples into the study to determine ZAP70 and CD38 status using immunohistochemistry. Expression patterns for both antibodies were then correlated with the bone marrow infiltration patterns. We also analyzed IgVH mutations in 20 patients using DNA obtained from paraffin-embedded formalin-fixed bone marrow biopsies. These findings were then correlated with immunohistochemical results. R Re es su ul lt ts s: : We identified a positive correlation between the expression patterns of ZAP70 and CD38, factors that were previously identified as poor prognostic factors (p<0.001). However, there was no correlation between these two markers and IgVH mutation status (p=1.000 and p=0.931). In addition, we showed a statistically significant positive correlation with ZAP70 immunostaining, and the necessity for an early intervention (p=0.046). ZAP70 and CD38 expressions were statistically significantly correlated with the diffuse pattern infiltration of bone marrow (p<0.001 and p<0.001, respectively). C Co on nc cl lu us si io on n: : Despite small number of our patients, the findings of our study suggested that ZAP70 and CD38 expression patterns as well as IgVH mutation status might be helpful to determine the course of the disease, and the risk of progression. Particularly ZAP70 immunopositive patients appear to have a faster disease progression, and may require earlier intervention and a closer follow up.K Ke ey y W Wo or rd ds s: : Leukemia, lymphocytic, chronic, B-cell; somatic hypermutation, immunoglobulin; ZAP70 protein, mouse; CD38 protein, mouse Ö ÖZ ZE ET T A Am ma aç ç: : Kronik lenfositik lösemi (KLL), batı toplumunda erişkinlerde en sık görülen lösemi türüdür. KLL'nin klinik seyrinden dolayı, hızlı seyredecek hastaları önceden belirlemek önemlidir. Bu çalışmada amaç, KLL'de hızlı progresyon ve agresif gidişle ilişkileri çeşitli çalışmalarla belirlenen ZAP70 ve CD38 antikorları ile İmmünglobu-lin ağır zincir değişken bölgesi (IgVH) mutasyon durumu arasındaki ilişkileri değerlendirmek, ve bunların ekspresyonunun kemik iliği infiltrasyon paternleri ile bağlantısını ortaya koymaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmaya retrospektif olarak alınan 84 olguya ait kemik iliği biyopsi örneklerinin parafin bloklarından elde edilen kesitlere avidin-biotin peroksidaz yöntemiyle ZAP70 ve CD38 antikorları uygulandı. Tümör ...

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Peripheral blood CD38 expression predicts survival in B-cell chronic lymphocytic leukemia

Cited by 44 publications

References 34 publications

Pharmacological inhibitors of NF-κB accelerate apoptosis in chronic lymphocytic leukaemia cells

Pharmacological inhibitors of NF-κB accelerate apoptosis in chronic lymphocytic leukaemia cells

Regulation of CD38 in proliferating chronic lymphocytic leukemia cells stimulated with CD154 and interleukin-4

Prognostic Significance of the IgVH Mutation Status and Immunohistochemical Analysis of ZAP70 and CD38 in Bone Marrow Biopsies in Chronic Lymphocytic Leukemia

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