Peripheral BETA-Endorphin in Rheumatoid Arthritis: A Correlation with the Disease Activity

Elbeialy, Adel; Elbarbary, Mahmoud; Kamel, M

doi:10.3109/03009749709115824

Cited by 15 publications

(12 citation statements)

References 16 publications

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“…The reasons for these findings are unclear; however, it is possible that mechanisms underlying DHA antinociception in acute pain models may be different from those involved in chronic pain states and/or there may be a decrease in the levels of endorphins in chronic arthritic conditions. In support of this theory, investigators in a clinical study demonstrated that there is an inverse correlation between serum levels of β-endorphins and rheumatoid disease activity score and the duration of RA [59]. …”

Section: Discussionmentioning

confidence: 99%

Chronic oral or intraarticular administration of docosahexaenoic acid reduces nociception and knee edema and improves functional outcomes in a mouse model of Complete Freund’s Adjuvant–induced knee arthritis

et al. 2014

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IntroductionClinical and preclinical studies have shown that supplementation with ω-3 polyunsaturated fatty acids (ω-3 PUFAs) reduce joint destruction and inflammation present in rheumatoid arthritis (RA). However, the effects of individual ω-3 PUFAs on chronic arthritic pain have not been evaluated to date. Thus, our aim in this study was to examine whether purified docosahexaenoic acid (DHA, an ω-3 PUFA) reduces spontaneous pain-related behavior and knee edema and improves functional outcomes in a mouse model of knee arthritis.MethodsUnilateral arthritis was induced by multiple injections of Complete Freund’s Adjuvant (CFA) into the right knee joints of male ICR adult mice. Mice that received CFA injections were then chronically treated from day 15 until day 25 post–initial CFA injection with oral DHA (10, 30 and 100 mg/kg daily) or intraarticular DHA (25 and 50 μg/joint twice weekly). Spontaneous flinching of the injected extremity (considered as spontaneous pain-related behavior), vertical rearing and horizontal exploratory activity (considered as functional outcomes) and knee edema were assessed. To determine whether an endogenous opioid mechanism was involved in the therapeutic effect of DHA, naloxone (NLX, an opioid receptor antagonist, 3 mg/kg subcutaneously) was administered in arthritic mice chronically treated with DHA (30 mg/kg by mouth) at day 25 post–CFA injection.ResultsThe intraarticular CFA injections resulted in increasing spontaneous flinching and knee edema of the ipsilateral extremity as well as worsening functional outcomes as time progressed. Chronic administration of DHA, given either orally or intraarticularly, significantly improved horizontal exploratory activity and reduced flinching behavior and knee edema in a dose-dependent manner. Administration of NLX did not reverse the antinociceptive effect of DHA.ConclusionsTo the best of our knowledge, this report is the first to demonstrate DHA’s antinociceptive and anti-inflammatory effects as individual ω-3 PUFAs following sustained systemic and intraarticular administration in a mouse model of CFA-induced knee arthritis. The results suggest that DHA treatment may offer a new therapeutic approach to alleviate inflammation as well as a beneficial effect on pain-related functional disabilities in RA patients.

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Section: Discussionmentioning

confidence: 99%

Chronic oral or intraarticular administration of docosahexaenoic acid reduces nociception and knee edema and improves functional outcomes in a mouse model of Complete Freund’s Adjuvant–induced knee arthritis

et al. 2014

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“…Some autoimmune diseases, such as RA (16, 17) and Crohn's disease, are related to β‐EP levels (18). The level of β‐EP is decreased in peripheral blood mononuclear cells of multiple sclerosis patients (7).…”

Section: Discussionmentioning

confidence: 99%

“…β‐EP participates in the regulating of the immune system as a hormone or neurotransmitter. Elbeialy et al found that plasma β‐EP levels in severe RA patients were significantly lower than in mild RA patients and that the mean plasma level of β‐EP was also significantly lower in both RA groups than in normal controls (16). Morch's reseach indicated that β‐EP can enhance the activity of NK cells and inhibit the function of B cells; what's more, β‐EP can directly inhibit the production of antibodies(20).…”

Section: Discussionmentioning

confidence: 99%

Detection of the Levels of Neuropeptides, ACTH and Cortisol in the Blood of Patients with Polymyositis/Dermatomyositis and Their Significance

Liu

Zhai

et al. 2004

The Journal of Dermatology

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Recent research has shown that the neuroendocrine system can regulate the function of the immune system and that ACTH and cortisol play important roles in maintaining the immune homeostasis. Polymyositis and dermatomyositis (PM/DM) are autoimmune diseases with unclear pathogeneses closely related with immune disorders, so we detected the levels of neuropeptide Y (NPY), beta-endorphin (beta-EP), calcitonin gene-related peptide (CGRP), adrenocoricotropic hormone (ACTH), and cortisol in blood of patients with PM/DM to investigate the relationship between these indices and the pathogenesis of PM/DM. The detection of NPY, beta-EP, CGRP, and ACTH concentrations in plasma and cortisol in serum of 28 cases of PM/DM was carried out using radioimmunoassay methods, and the results were compared with those of 20 normal controls. The levels of NPY in the plasma of PM/DM was significantly higher than those of the controls, while beta-EP, CGRP and ACTH were significantly lower than those of the controls, and cortisol was not significantly different before treatment. Linear correlation analysis indicated that NPY was significantly positively correlated with CPK, and beta-EP and CGRP were significantly negatively correlated with CPK. There were no significant correlations among cortisol ACTH, and CPK and no significant correlations between NPY, beta-EP, CGRP, ACTH, cortisol and age or duration of disease before treatment. After treatment for three months, NPY, beta-EP and CGRP tended to become normal and no longer significantly different from the control values. However, ACTH fell further and was significantly lower than the level before treatment. Therefore the increase in NPY and the decreases in beta-EP, CGRP, and ACTH in the plasma of PM/DM patients may be related to the pathogenesis of PM/DM.

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“…Неспособность ответить адекватным повышением продукции ЭО в рамках аллостаза снижает устойчивость к воздействию стресса и способствует развитию дистресса. В большинстве исследований показано снижение уровней ЭО в крови и цереброспинальной жидкости больных РА [54]. Выявлена обратная корреляция уровней ЭО в сыворотке и клетках крови с активностью и тяжестью течения РА [54].…”

Section: общие патогенетические механизмы развития дистресса и ревматunclassified

Psychological stress and rheumatoid arthritis – interference of pathogenetic mechanisms

Tuaeva

Nosyrev

Ренадино

et al. 2019

Naučno-praktičeskaâ revmatologiâ

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Molecular mechanisms of development of normal and pathological neuroendocrine and immune adaptive response to psychological (mental) stress are analyzed considering its possible provoking role in the development of rheumatoid arthritis (RA). A detailed analysis reveals the synergism of mechanisms that provoke the development of pathological anti-stress adaptive response and RA. It is possible that in persons at risk of developing RA minimal and unobtrusive for the individual stressful situations, periodically provoking prolonged production of pro-inflammatory cytokines, can, finally, lead to the development of rheumatic disease.

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Peripheral BETA-Endorphin in Rheumatoid Arthritis: A Correlation with the Disease Activity

Cited by 15 publications

References 16 publications

Chronic oral or intraarticular administration of docosahexaenoic acid reduces nociception and knee edema and improves functional outcomes in a mouse model of Complete Freund’s Adjuvant–induced knee arthritis

Chronic oral or intraarticular administration of docosahexaenoic acid reduces nociception and knee edema and improves functional outcomes in a mouse model of Complete Freund’s Adjuvant–induced knee arthritis

Detection of the Levels of Neuropeptides, ACTH and Cortisol in the Blood of Patients with Polymyositis/Dermatomyositis and Their Significance

Psychological stress and rheumatoid arthritis – interference of pathogenetic mechanisms

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