Psychological stress and rheumatoid arthritis – interference of pathogenetic mechanisms

In this review, we explore systemization of knowledge about the triggering effects of non-genetic factors in pathogenic mechanisms that contribute to the development of rheumatoid arthritis (RA). Possible mechanisms involving environmental and individual factors in RA pathogenesis were analyzed, namely, infections, mental stress, sleep deprivation ecology, age, perinatal and gender factors, eating habits, obesity and smoking. The non-genetic factors modulate basic processes in the body with the impact of these factors being non-specific, but these common challenges may be decisive for advancement of the disease in the predisposed body at risk for RA. The provocation of this particular disease is associated with the presence of congenital loci minoris resistentia. The more frequent non-genetic factors form tangles of interdependent relationships and, thereby, several interdependent external factors hit one vulnerable basic process at once, either provoking or reinforcing each other.Understanding the specific mechanisms by which environmental and individual factors impact an individual under RA risk in the preclinical stages can contribute to early disease diagnosis and,if the factor is modifiable, might be useful for the prevention or delay of its development.

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“…Analysis in the GWAS Catalog [ 112 ] revealed 14 matches of RA-and-depression-associated SNPs ( Figure 2 ).…”

Section: Methodsmentioning

confidence: 99%

Interplay of Environmental, Individual and Genetic Factors in Rheumatoid Arthritis Provocation

Arleevskaya

Takha

Petrov

et al. 2022

IJMS

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Харчування Як Чинник Ризику Та Втручання При Ревматичних Захворюваннях

Puzanova¹

2021

PJS

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The purpose of the paper is to provide a review of the effects of nutrition as a risk factor and intervention in the aspect of rheumatic diseases. Using information analysis methods, more than 100 special literature sources have been studied, including evidence based medicine computer databases. The significance of nutrition as a risk factor for the development and outcomes, first of all for rheumatoid arthritis and gout, is proved in large observational studies, systematic reviews and metaanalysis dedicated to both preventive and therapeutic potential as well as to safety of different food products, diets, micronutrients and probiotics, including in connection with associated main risk factors of noninfectious diseases (tobacco smoking, alcohol consumption, increased body mass index). The pathogenetic role of nutrition is considered in the context of its influence on gut microbiota. Necessity of the randomized controlled trials is shown in order to assess the protective potential of different nutritional patterns, as well as the effects of modified Mediterranean diet, some dietary supplements and probiotics intake in rheumatic diseases, and as a result-to develop special guidelines on nutrition in rheumatic patients. There is a sufficient evidence base of preventive counse ling of such patients on nutritional issues with the aim of cardiovascular risk reduction.

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Psychological stress and rheumatoid arthritis – interference of pathogenetic mechanisms

Cited by 2 publications

References 54 publications

Interplay of Environmental, Individual and Genetic Factors in Rheumatoid Arthritis Provocation

Interplay of Environmental, Individual and Genetic Factors in Rheumatoid Arthritis Provocation

Харчування Як Чинник Ризику Та Втручання При Ревматичних Захворюваннях

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