Peripheral benzodiazepine receptors on platelets of fibromyalgic patients

Bazzichi, Laura; Giannaccini, Gino; Betti, Laura; Italiani, P.; Fabbrini, Laura; Defeo, F. G.; Giacomelli, Camillo; Giuliano, Tiziana; Rossi, Alessandra; Uccelli, Angela; Giusti, Laura; Mascia, G.; Lucacchini, Antonio; Bombardieri, Stefano

doi:10.1016/j.clinbiochem.2006.06.002

Cited by 16 publications

(13 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…of Rheumatology, Santa Chiara Hospital, Pisa. The admission criteria for patients and controls were the same used in our previous works [32,33] and comprised a negative history for major psychiatric illnesses or neurological disorders. Comorbidity with psychiatric disorders was evaluated by means of the Structural Clinical Interview for DSM IV axis-I disorder (SCID-I/P) [34].…”

Section: Subjectsmentioning

confidence: 99%

“…Prior to blood sampling and analysis, the assessment of FM clinical parameters was conducted as described in our previous studies [32,33]. Each patient was evaluated for tenderness at TPs by means of the Fischer dolorimeter [35], using a pain scale between 0 (no pain) and 3 (severe pain).…”

Section: Clinical Parametersmentioning

confidence: 99%

“…Moreover, platelets present on their plasma membrane either pain/inflammation or neurochemical sites, such as adenosine/monoamine receptors and transporters [29,30], enabling the study of either neurochemistry or ATP energy metabolism in FM. Some recent studies carried out in our laboratory have shown a significant increase of the platelet peripheral benzodiazepine receptor (PBR) (now named traslocator protein, TSPO, [31]) together with high plasma levels of the pro-inflammatory chemokine interleukine 8 (IL-8), low serum cortisol [32] as well as a reduced density and functionality of the platelet 5-HT transporter (SERT) [33] in FM patients. As a consequent step, we decided to pursue the search by comparing ATP, calcium and magnesium levels inside platelets obtained from a group of FM patients enrolled at our Department and in a group of sex-age matched healthy volunteers.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

ATP, calcium and magnesium levels in platelets of patients with primary fibromyalgia

Bazzichi

Giannaccini

Betti

et al. 2008

Clinical Biochemistry

View full text Add to dashboard Cite

Section: Subjectsmentioning

confidence: 99%

Section: Clinical Parametersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

ATP, calcium and magnesium levels in platelets of patients with primary fibromyalgia

Bazzichi

Giannaccini

Betti

et al. 2008

Clinical Biochemistry

View full text Add to dashboard Cite

“…Our research group have been studying FM since 2003, publishing numerous articles about this item [7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Thyroid autoimmunity may represent a predisposition for the development of fibromyalgia?

et al. 2010

Self Cite

View full text Add to dashboard Cite

In our previous study, we observed that the presence of autoimmune thyroid disease worsens fibromyalgia (FM) symptoms. The aims of this study are to evaluate whether there is a predisposition for the development of FM in patients with Hashimoto's thyroiditis (HT) with or without subclinical hypothyroidism (SCH) and in patients with SCH alone and what is the weight of antithyroid antibody positivity and SCH on FM comorbidity. Fifty-two patients, 39 affected by HT with or without SCH and 13 by SCH, were matched with 37 patients affected by FM and 25 healthy subjects. Blood samples were collected from all study subjects for the determination of serum TSH, free triiodothyronine, free thyroxine, antithyroperoxidase antibody (TPOAb), antithyroglobulin antibody (TgAb) and non-organ-specific autoantibodies. Clinical assessment of patients and controls included the "Fibromyalgia Impact Questionnaire" (FIQ), while pain severity was evaluated using a visual analogue scale (VAS). Patients and controls were also characterized by the presence of diffuse pain, fatigue, paresthesiae, muscle spasms, non-restful sleep, tension headache and presence of mood disorders. FM comorbidity resulted in twelve HT subjects (31%) and none in SCH patient. In particular, FM comorbidity in HT patients without SCH was 33.3% and in HT patients with SCH was 28.5%. Based on our data, we speculate that maybe there is more than a hypothesis regarding the cause-effect relation between thyroid autoimmunity and the presence of FM, thus suggesting a hypothetical role of thyroid autoimmunity in FM pathogenesis.

show abstract

“…Il est intéressant de noter cependant que, si l'étape TSPO est court-circuitée en fournissant de la progestérone exogène, il est alors possible d'induire la production de neurostéroïdes 3α-réduits et de potentialiser l'inhibition GABAergique dans cette couche [47]. Les conséquences fonctionnelles de cette observation pourraient se révéler très intéressantes en cas de fortes variations hormonales et dans les situations pathologiques où le TSPO est parfois surexprimé [5,50,55].…”

Section: Inflammations Douloureusesunclassified

Neurosteroid and pain

Keller

Poisbeau

2009

Douleur analg

View full text Add to dashboard Cite

Les neurostéroïdes sont synthétisés par les cellules du système nerveux à partir de cholestérol ou de précurseurs stéroïdiens circulants. Comme les autres stéroïdes, ils exercent de puissants effets activationnels sur les fonctions cérébrales dont une partie est médiée par l'action sur des récepteurs membranaires. Cette revue fait le point sur les effets membranaires rapides des neurostéroïdes et leurs conséquences fonctionnelles sur l'expression douloureuse en expérimentation animale. À côté de leurs effets thérapeutiques potentiels en application exogène, les neurostéroïdes endogènes sont impliqués dans la modulation des messages « douloureux » périphériques dans la grande majorité des structures relais du système nociceptif en situations physiologique ou pathologique. La meilleure connaissance des mécanismes qui contrôlent la neurosté-roïdogenèse endogène devrait permettre à l'avenir d'ouvrir de nouvelles pistes thérapeutiques pour le traitement des douleurs neuropathiques et des douleurs inflammatoires. Mots clés Nociception · Récepteur mitochondrial des benzodiazépines · Douleurs inflammatoire ou neuropathique · Récepteurs GABA A · AlloprégnanoloneAbstract Neurosteroids are synthesized by nerve cells from cholesterol or from circulating steroid precursors. Like other steroids, they exert powerful activational effects on brain functions, part of which are mediated by neurotransmitter receptor expressed at the plasma membrane. This review provides an update on the membrane effects of neurosteroids and their functional consequences on the expression in pain symptoms in animal experimentation. Apart from their potential therapeutic use if exogenously administered, endogenous neurosteroids are involved in the modulation peripheral "pain" messages in the vast majority of relay nociceptive structures, in physiological and pathological states. A better understanding of the mechanisms that control neurosteroidogenesis is expected to open new therapeutic strategies for the treatment of neuropathic and inflammatory pain.

show abstract

Peripheral benzodiazepine receptors on platelets of fibromyalgic patients

Cited by 16 publications

References 52 publications

ATP, calcium and magnesium levels in platelets of patients with primary fibromyalgia

ATP, calcium and magnesium levels in platelets of patients with primary fibromyalgia

Thyroid autoimmunity may represent a predisposition for the development of fibromyalgia?

Neurosteroid and pain

Contact Info

Product

Resources

About