ATP, calcium and magnesium levels in platelets of patients with primary fibromyalgia

Bazzichi, Laura; Giannaccini, Gino; Betti, Laura; Fabbrini, Laura; Schmid, Lara; Palego, Lionella; Giacomelli, Camillo; Rossi, Alessandra; Giusti, Laura; Feo, Francesca De; Giuliano, Tiziana; Mascia, G.; Bombardieri, Stefano; Lucacchini, Antonio

doi:10.1016/j.clinbiochem.2008.06.012

Cited by 37 publications

(27 citation statements)

References 47 publications

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“…The central augmentation of sensory input is associated with enhanced sensitivity to pain. Also, the chronic pain and allodynia in FM as well as in mood disorders are associated with significantly lower levels of ATP in platelets, which has been implicated in their pathogenesis [42][43]. Likely, ELF-MF reduces pain by relieving peripheral input in FM patients and has short latency effects (1 mo), even after the end of treatment and despite the modulation of biochemical mediators of pain, maintaining a short biochemical memory [44].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of extremely low-frequency magnetic field in fibromyalgia pain: A pilot study

et al. 2016

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Abstract-The purpose of this pilot study was to determine the efficacy of an extremely low-frequency magnetic field (ELF-MF) in decreasing chronic pain in fibromyalgia (FM) patients. Thirty-seven females were recruited and randomized into two groups: one group was first exposed to systemic ELF-MF therapy (100 microtesla, 1 to 80 Hz) and then to sham therapy, and the other group received the opposite sequence of intervention. Pain, FM-related symptoms, and the ability to perform daily tasks were measured using the Visual Analog Scale, Fibromyalgia Impact Questionnaire (FIQ), Fibromyalgia Assessment Scale (FAS), and Health Assessment Questionnaire (HAQ) at baseline, end of first treatment cycle, beginning of second treatment cycle (after 1 mo washout), end of second treatment cycle, and end of 1 mo follow-up. ELF-MF treatment significantly reduced pain, which increased on cessation of therapy but remained significantly lower than baseline levels. Short-term benefits were also observed in FIQ, FAS, and HAQ scores, with less significant effects seen in the medium term. ELF-MF therapy can be recommended as part of a multimodal approach for mitigating pain in FM subjects and improving the efficacy of drug therapy or physiotherapy.Clinical Trial Registration: ClinicalTrials.gov; "Very low frequency magnetic fields in the treatment of fibromyalgia": NCT02231541;https://clinicaltrials.gov/ct2/show/ NCT02231541?term=NCT02231541&rank=1

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Section: Discussionmentioning

confidence: 99%

Efficacy of extremely low-frequency magnetic field in fibromyalgia pain: A pilot study

et al. 2016

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“…Reduction in ATP levels also has been observed in the erythrocytes of FM patients, suggesting that this may be a more systemic phenomenon than was previously assumed (Russell et al, 1993). Recently, it has also been noted a decrease of ATP levels in platelets from FM patients (Bazzichi et al, 2008). Blood platelets represent an easily available and simple peripheral model to study bioenergetics alterations in FM.…”

Section: Mitochondrial Dysfunction In Fmmentioning

confidence: 93%

The Role of Oxidative Stress and Mitochondrial Dysfunction in the Pathogenesis of Fibromyalgia

Cordero¹,

Miguel²,

Alcázar³

2012

New Insights Into Fibromyalgia

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“…It has been considered as a musculoskeletal disease, but also more recently as a neuropsychiatric condition. It has been shown that there are significantly lower levels of ATP in platelets of fibromyalgia patients and it was suggested that this may be of relevance in the pathogenesis of the disease [363].…”

Section: Fibromyalgiamentioning

confidence: 99%

Purinergic signalling in the musculoskeletal system

Burnstock

Arnett

Orriss

2013

Purinergic Signalling

109

114

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It is now widely recognised that extracellular nucleotides, signalling via purinergic receptors, participate in numerous biological processes in most tissues. It has become evident that extracellular nucleotides have significant regulatory effects in the musculoskeletal system. In early development, ATP released from motor nerves along with acetylcholine acts as a cotransmitter in neuromuscular transmission; in mature animals, ATP functions as a neuromodulator. Purinergic receptors expressed by skeletal muscle and satellite cells play important pathophysiological roles in their development or repair. In many cell types, expression of purinergic receptors is often dependent on differentiation. For example, sequential expression of P2X5, P2Y 1 and P2X2 receptors occurs during muscle regeneration in the mdx model of muscular dystrophy. In bone and cartilage cells, the functional effects of purinergic signalling appear to be largely negative. ATP stimulates the formation and activation of osteoclasts, the bone-destroying cells. Another role appears to be as a potent local inhibitor of mineralisation. In osteoblasts, the bone-forming cells, ATP acts via P2 receptors to limit bone mineralisation by inhibiting alkaline phosphatase expression and activity. Extracellular ATP additionally exerts significant effects on mineralisation via its hydrolysis product, pyrophosphate. Evidence now suggests that purinergic signalling is potentially important in several bone and joint disorders including osteoporosis, rheumatoid arthritis and cancers. Strategies for future musculoskeletal therapies might involve modulation of purinergic receptor function or of the ecto-nucleotidases responsible for ATP breakdown or ATP transport inhibitors.

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ATP, calcium and magnesium levels in platelets of patients with primary fibromyalgia

Cited by 37 publications

References 47 publications

Efficacy of extremely low-frequency magnetic field in fibromyalgia pain: A pilot study

Efficacy of extremely low-frequency magnetic field in fibromyalgia pain: A pilot study

The Role of Oxidative Stress and Mitochondrial Dysfunction in the Pathogenesis of Fibromyalgia

Purinergic signalling in the musculoskeletal system

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