Peripheral and central control of obesity by primary cilia

Wu, Yue; Zhou, Jun; Yang, Yunfan

doi:10.1016/j.jgg.2022.12.006

Cited by 10 publications

(8 citation statements)

References 108 publications

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“…neuropilin‐1 (NP‐1) high expression level correlates with adipocytes accumulation in bone marrow of femoral, which could down‐regulate granulocyte colony‐stimulating factor (G‐CSF) production and then lead to defective granulocytes production. 53 , 54 PPARγ deficient mice showed decreased MEP, increased GMP and increased granulocyte/macrophage progenitor cell ratio, but no change in CMP in BM compared with wild‐type mice. Meanwhile, Sfpi/PU1 and Gata2 levels were increased while Gata1 remained unchanged in long bone of PPARγΔ/Δ mice.…”

Section: Marrow Adipose Tissue Affects Hematopoietic Homeostasismentioning

confidence: 90%

“…In addition, it has been reported that MAT can directly contact with hematopoietic cells. neuropilin‐1 (NP‐1) high expression level correlates with adipocytes accumulation in bone marrow of femoral, which could down‐regulate granulocyte colony‐stimulating factor (G‐CSF) production and then lead to defective granulocytes production 53,54 . PPARγ deficient mice showed decreased MEP, increased GMP and increased granulocyte/macrophage progenitor cell ratio, but no change in CMP in BM compared with wild‐type mice.…”

Section: Marrow Adipose Tissue Affects Hematopoietic Homeostasismentioning

confidence: 99%

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Adipose tissue and hematopoiesis: Friend or foe?

Liu

2023

Clinical Laboratory Analysis

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Aim Hematopoietic stem cells are the origin of all hematopoietic cells. They have the self‐renewal ability and can differentiate into various blood cells. In physiological state, most of the hematopoietic stem cells are dormant, and only a few cells proliferate to maintain hematopoietic homeostasis. Methods This precise steady‐state maintenance is regulated by complex mechanisms. Bone marrow adipocytes make up half of all cells in the bone marrow cavity, a feature that has attracted the attention of researchers from multiple fields. The adipocyte density within marrow increases during aging and obesity. Results Recent studies have shown that bone marrow adipocytes play important roles in regulating hematopoiesis, but the effects of bone marrow adipocytes on hematopoiesis are often conflicting. Bone marrow adipocytes, participating in the formation of bone marrow hematopoietic microenvironment, influence hematopoiesis positively or negatively. In addition, other adipose tissue, especially white adipose tissue, also regulates hematopoiesis. Conclusion In this review, we describe the role of adipose tissue in hematological malignancies, which may be useful for understanding hematopoiesis and the pathogenesis of related diseases.

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Section: Marrow Adipose Tissue Affects Hematopoietic Homeostasismentioning

confidence: 90%

Section: Marrow Adipose Tissue Affects Hematopoietic Homeostasismentioning

confidence: 99%

Adipose tissue and hematopoiesis: Friend or foe?

Liu

2023

Clinical Laboratory Analysis

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“…Hh signaling plays a pivotal role in HF development and epidermal maintenance (Lee et al, 2017). Cilia dysfunction in the kidney facilitates the disorganization of directional cell division (Ran et al, 2021; Rizaldy et al, 2021; Wu et al, 2023). Furthermore, studies based on K14‐Cre and IFT88‐flox epidermal tissue‐specific knockout mice found that IFT88 knockout leads to epidermis thickening, basal layer hyperplasia, and tail HF SG dysplasia, which implies that loss of cilia on the epidermis might considerably impact skin homeostasis (Yang et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Regulation of epidermal stratification and development by basal keratinocytes

Yin

2023

Journal Cellular Physiology

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The epidermis is a stratified squamous epithelium distributed in the outermost layer of the skin and is intimately involved in the formation of a physical barrier to pathogens. Basal keratinocytes possess the properties of stem cells and play an essential role in epidermal development and skin damage recovery. Therefore, understanding the molecular mechanism of how basal keratinocytes participate in epidermal development and stratification is vital for preventing and treating skin lesions. During epidermal morphogenesis, the symmetric division of basal keratinocytes contributes to the extension of skin tissues, while their asymmetric division and migration facilitate epidermal stratification. In this review, we summarize the process of epidermal stratification and illustrate the molecular mechanisms underlying epidermal morphogenesis. Furthermore, we discuss the coordination of multiple signaling pathways and transcription factors in epidermal stratification, together with the roles of cell polarity and cell dynamics during the process.

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“…Intraflagellar transport 88 (IFT88), a component of the IFT system, is vital for cilium formation and maintenance (Coveney, Samvelyan, et al, 2022; W. Li et al, 2022; Y. Yang et al, 2021). Mutations or disruptions in IFT88 have been implicated in cilia dysfunction, leading to the development of ciliopathies, including polycystic liver and kidney disease (Coveney, Zhu, et al, 2022; R. Fujii et al, 2021; Shao et al, 2020; Y. Wu et al, 2023; S. Yang et al, 2023). Cholangiocyte cilia are believed to be critical in sensing and responding to changes in bile flow and composition (Amarachintha et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…IFT88 have been implicated in cilia dysfunction, leading to the development of ciliopathies, including polycystic liver and kidney disease (Coveney, Zhu, et al, 2022;R. Fujii et al, 2021;Shao et al, 2020;Y. Wu et al, 2023;S.…”

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confidence: 99%

Primary cilium‐mediated signaling cascade suppresses age‐related biliary fibrosis

Hong,

Tian,

et al. 2023

Journal Cellular Physiology

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The primary cilium is increasingly recognized as a crucial player in the physiology of biliary epithelial cells (BECs). However, the precise role of primary cilia in the development of age‐related biliary fibrosis remains unclear. Herein, using cilium‐deficient mice, we demonstrate that disruption of ciliary homeostasis in BECs in aged mice leads to significant bile duct proliferation, augmented biliary fibrosis, and heightened indicators of liver injury. Our RNA‐sequencing data revealed a dysregulation in genes associated with various biological processes such as bile secretion, fatty acid metabolism, and inflammation. Loss of primary cilia also significantly enhanced signaling pathways driving the development of biliary fibrosis. Our findings collectively suggest that loss of primary cilia in the BECs of aged mice initiates a cascade of signaling events that contribute to biliary fibrosis, highlighting the primary cilium as a potential therapeutic target in the treatment of fibrosing cholangiopathies.

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Peripheral and central control of obesity by primary cilia

Cited by 10 publications

References 108 publications

Adipose tissue and hematopoiesis: Friend or foe?

Adipose tissue and hematopoiesis: Friend or foe?

Regulation of epidermal stratification and development by basal keratinocytes

Primary cilium‐mediated signaling cascade suppresses age‐related biliary fibrosis

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