Periparturient insulin secretion and whole-body insulin responsiveness in dairy cows showing various forms of ketone pattern with or without puerperal metritis

Kerestes, M.; Faigl, V.; Kulcsár, Margit; Balogh, Orsolya; Foldi, Julia; Fébel, Hedvig; Chilliard, Yves; Huszenicza, G.

doi:10.1016/j.domaniend.2009.07.003

Cited by 93 publications

(92 citation statements)

References 32 publications

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Section: Resultsunclassified

“…Nesse contexto, foi demonstrado em humanos que a administração de insulina aumenta a excreção de cálcio e magnésio (Defronzo et al, 1976), assim como em pacientes portadores de diabetes tipo II com resistência à insulina (Lee et al, 2006). Este mecanismo ainda não está completamente esclarecido, mas sabe-se que a insulina aumenta a excreção desses minerais por mudanças nas trocas eletrolíticas no túbulo contorcido distal, elevando a retenção de sódio e potássio, importante para pacientes insulino-dependentes portadores de hipertensão (Lee et al, 2006). Esta ação da insulina pode ter relevância clínica na ocorrência de hipocalcemia e hipomagnesemia em ruminantes alimentados com alto nível de energia no pré-parto, já que o grau de adiposidade neste período está associado a maiores concentrações séricas de insulina, aumentando a resistência a este hormônio nos tecidos periféricos (Beever, 2006;Kerestes et al, 2009;Roche et al, 2009).…”

Section: Resultsunclassified

“…Este mecanismo ainda não está completamente esclarecido, mas sabe-se que a insulina aumenta a excreção desses minerais por mudanças nas trocas eletrolíticas no túbulo contorcido distal, elevando a retenção de sódio e potássio, importante para pacientes insulino-dependentes portadores de hipertensão (Lee et al, 2006). Esta ação da insulina pode ter relevância clínica na ocorrência de hipocalcemia e hipomagnesemia em ruminantes alimentados com alto nível de energia no pré-parto, já que o grau de adiposidade neste período está associado a maiores concentrações séricas de insulina, aumentando a resistência a este hormônio nos tecidos periféricos (Beever, 2006;Kerestes et al, 2009;Roche et al, 2009). Tal fato, somado à maior taxa de filtração glomerular na gestante (Baylis, 1994;Thornburg et al, 2000), poderia predispor à hipocalcemia e à hipomagnesemia, pela perda destes minerais via filtração renal (Defronzo et al, 1976).…”

Section: Resultsunclassified

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Correlação entre cálcio e insulina durante o teste de tolerância à glicose em ovelhas gestantes e não gestantes

Schmitt

Schneider

Goulart

et al. 2012

Arq. Bras. Med. Vet. Zootec.

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RESUMOCompararam-se as concentrações de cálcio, glicose e insulina em ovelhas gestantes e não gestantes submetidas ao teste de tolerância à glicose (TTG). Oito ovelhas gestantes (GG) e oito não gestantes (NG) foram submetidas ao TTG por meio da administração endovenosa de uma solução de glicose, na dose de 500mg/kg de peso vivo. Amostras de sangue foram coletadas nos tempos de -15, zero, 15, 30, 45, 60, 90, 120, 150 e 180 minutos, sendo zero min o momento da infusão, para avaliação da concentração sanguínea de glicose, cálcio e insulina. Foi avaliada a taxa de metabolização de glicose e insulina, por meio do cálculo da área sob a curva (ASC). As concentrações de glicose, cálcio, insulina e a ASC da insulina não diferiram entre os grupos (P>0,05), entretanto as três últimas ASCs da glicose foram mais elevados nas gestantes (P<0,05), que correspondem ao período entre 90 e 180min. O teste de correlação de Pearson revelou correlação negativa entre concentração de cálcio e insulina nas gestantes (P<0,05). Estes resultados indicam menor taxa de metabolização de glicose em ovelhas gestantes e uma possível relação de cálcio e insulina no terço final de gestação.Palavras-chave: gestação, ovelha, teste de tolerância, glicose, insulina on -15, 0, 15, 30, 45, 60, 90, 120, 150 and 180 minutes interval (0 mininjection condição induz a adaptações no metabolismo da gestante, levando à maior ingestão calórica e ao aumento da resposta secretória de insulina (Brelje et al., 1993). Nesse período, cerca de 35% da glicose circulante da gestante são direcionadas para atender à demanda energética da unidade feto-placentária, sustentada pela redução progressiva e reversível da sensibilidade ABSTRACT

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Section: Resultsunclassified

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Correlação entre cálcio e insulina durante o teste de tolerância à glicose em ovelhas gestantes e não gestantes

Schmitt

Schneider

Goulart

et al. 2012

Arq. Bras. Med. Vet. Zootec.

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“…The different indices provide similar but not identical results, so that more than one index should be used (Muniyappa et al, 2008). Some of these indices have already been applied in studies on dairy cows (Holtenius and Holtenius, 2007;Balogh et al, 2008;Kerestes et al, 2009) and, in addition, some studies reported similar changes in the values for QUICKI, RQUICKI, RQUICKI-BHB and parameters of glucose tolerance tests (Balogh et al, 2008;Bossaert et al, 2009). However, as a consequence of the differences in glucose metabolism between dry and lactating cattle, due to the processes involved in nutrition partitioning for milk production, these indices should not be used for comparisons throughout the periparturient period and therefore are only used here for comparisons between the two management systems at the same stage.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of the metabolic profile, insulin sensitivity and inflammatory response between organically and conventionally managed dairy cattle during the periparturient period

Abuelo

Hernández

Benedito

et al. 2014

Animal

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The number of organically managed cattle (OMC) within the European Union has increased tremendously in the last decade. However, there are still some concerns about animals under this farming system meeting their dietary requirements for milk production. The aim of this study was to compare the metabolic adaptations to the onset of lactation in three different herds, one conventional and two organic ones. Twenty-two conventionally managed cattle (CMC) and 20 from each organic farm were sampled throughout the periparturient period. These samplings were grouped into four different stages: (i) far-off dry, (ii) close-up dry, (iii) fresh and (iv) peak of lactation and compared among them. In addition, the results of periparturient animals were also compared within each management type with a control group (animals between the 4th and 5th months of pregnancy). Metabolic profiles were used to assess the health status of the herds, along with the quantification of the acute phase proteins haptoglobin and serum amyloid A, insulin and the calculation of different surrogate indices of insulin sensitivity. Generalised linear mixed models with repeated measurements were used to study the effect of the stage, management type or their interaction on the serum variables studied. The prevalence of subclinical ketosis was higher in OMC, although they showed better insulin sensitivity, a lower degree of inflammation and less liver injury, without a higher risk of macromineral deficiencies. Therefore, attention should be paid on organic farms to the nutritional management of cows around the time of calving in order to prevent the harmful consequences of excessive negative energy balance. Moreover, it must be taken into account that most of the common practices used to treat this condition in CMC are not allowed on a systematic basis in OMC.

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“…Biochemical parameters were measured using available commercial kits by means of the automated clinical chemistry analyzer Konelab 60I (Thermo Electron Corporation). Free-insulin concentration in each sample was quantifi ed with a commercial 125I-IRMA kit developed for human samples (BI-Ins IRMA kit; CIS Bio International Ltd.) and previously validated for bovine plasma samples [19]. NEFA concentration was determined by using a colorimetric method, NEFA RX Monza test (kit no.…”

Section: Farm and Animalsmentioning

confidence: 99%

Changes in Thyroid Hormones Levels and Metabolism in Dairy Cows around Calving

et al. 2017

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The hormonal activity of the thyroid gland has an important role in ruminants for the modulation of metabolic variables. In this study changes in thyroid hormones and biochemical parameters in dairy cows around calving were evaluated and the critical thyroid hormones thresholds for predicting the risk of ketosis were estimated. Blood samples were collected from 82 dairy cows at 5±3 days pre-partum and 5±3 days postpartum. Serum values of triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), non-esterifi ed fatty acids (NEFA), β-hydroxybutyrate (BHB), insulin, glucose, Ca, Cl, Mg, P, K, Na, aspartate transaminase (AST), alanine transaminase (ALT) and urea were evaluated. Signifi cant decrease in the levels of T3, T4 and TSH was found in the postpartum period. The values of T3 and T4 were negatively correlated with NEFA and BHB levels, and TSH values were negatively correlated with NEFA. A critical T3 threshold was found by means of ROC analysis for predicting the risk of ketosis. T3 values < 1.23 nmol/L were associated with BHB > 1.10 mmol/L in postpartum, which represents the BHB threshold commonly used as the indicator of hyperketonaemia.The results confi rm that the peripartum period is accompanied by marked changes in circulating thyroid hormone profile that is correlated with lipomobilization predictors.

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Periparturient insulin secretion and whole-body insulin responsiveness in dairy cows showing various forms of ketone pattern with or without puerperal metritis

Cited by 93 publications

References 32 publications

Correlação entre cálcio e insulina durante o teste de tolerância à glicose em ovelhas gestantes e não gestantes

Correlação entre cálcio e insulina durante o teste de tolerância à glicose em ovelhas gestantes e não gestantes

A comparative study of the metabolic profile, insulin sensitivity and inflammatory response between organically and conventionally managed dairy cattle during the periparturient period

Changes in Thyroid Hormones Levels and Metabolism in Dairy Cows around Calving

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