Peripartum Cardiomyopathy

Goland, Sorel; Elkayam, Uri

doi:10.1002/9781119409861.ch10

Cited by 2 publications

(4 citation statements)

References 187 publications

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“…118 The cause of this disease remains unclear, although plausible causes such as malnutrition, viral infections, stress-activated cytokines, pathological response to hemodynamic stress, inflammation, and autoimmune reactions have been reported. 116 Evidence supports the probable role of PRL in the pathophysiology of this disease. Increased oxidative stress leads to the production of the 16 kDa form of PRL, which disrupts the heart's vessels and metabolism and peaks in systolic heart failure.…”

Section: Hyperprolactinemia and Peripartum Cardiomyopathymentioning

confidence: 72%

“…Blood platelets are also an important component in thrombus formation. In general, research suggests that PRL may contribute to CVD by directly modulating local cellular processes in atherosclerotic plaques or thrombi or by affecting common cardiovascular metabolic factors 116…”

Section: Common Side Effects Of Hyperprolactinemiamentioning

confidence: 99%

“…The increase of knowledge and advancement of diagnostic and therapeutic insights have been effective in treating patients with PPCM in recent years 118. The cause of this disease remains unclear, although plausible causes such as malnutrition, viral infections, stress-activated cytokines, pathological response to hemodynamic stress, inflammation, and autoimmune reactions have been reported 116. Evidence supports the probable role of PRL in the pathophysiology of this disease.…”

Section: Common Side Effects Of Hyperprolactinemiamentioning

confidence: 99%

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Recent Findings on Hyperprolactinemia and its Pathological Implications: A Literature Review

Ghoreshi

Akbari

Sharif-zak

et al. 2022

Journal of Investigative Medicine

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The prolactin hormone (PRL) is often secreted by lactotrophic cells of the anterior pituitary and has been shown to play a role in various biological processes, including breast feeding and reproduction. The predominant form of this hormone is the 23 kDa form and acts through its receptor (PRLR) on the cell membrane. This receptor is a member of the superfamily of hematopoietic/cytokine receptors. PRL also has a 16 kDa subunit with anti-angiogenic, proapoptotic, and anti-inflammatory effects which is produced by the proteolytic breakdown of this hormone under oxidative stress. Although the common side effects of hyperprolactinemia are exerted on the reproductive system, new studies have shown that hyperprolactinemia has a wide variety of effects, including playing a role in the development of autoimmune diseases and increasing the risk of cardiovascular disease, peripartum cardiomyopathy, and diabetes among others. The range of PRL functions is increasing with the discovery of multiple sites of PRL secretion as well as PRLR expression in various tissues. This review summarizes current knowledge of the biology of PRL and its receptor, as well as the role of PRL in human pathophysiology.

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Section: Hyperprolactinemia and Peripartum Cardiomyopathymentioning

confidence: 72%

Section: Common Side Effects Of Hyperprolactinemiamentioning

confidence: 99%

Section: Common Side Effects Of Hyperprolactinemiamentioning

confidence: 99%

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Recent Findings on Hyperprolactinemia and its Pathological Implications: A Literature Review

Ghoreshi

Akbari

Sharif-zak

et al. 2022

Journal of Investigative Medicine

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“…The onset comprising from the last month of pregnancy until five months postpartum ( 1 ). The diagnostic criteria are development of heart failure (HF) in the last month of pregnancy to five months postpartum, no other possible etiology of HF, and no history of heart disease prior to last month of pregnancy ( 2 ). Symptoms associated with PPCM are highly variable including fatigue, dyspnea, orthopnea, palpitations, edema, chest pain, decreased endurance in exercise, and abdominal discomfort due to liver congestion ( 1 ).…”

Section: Introductionmentioning

confidence: 99%

Global Research Trends and Future Direction in Peripartum Cardiomyopathy: A Bibliometric Analysis

Wijayanto,

Lukas,

Greatalya

et al. 2023

Acta Inform Med

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Background: Peripartum cardiomyopathy (PPCM) is a pregnancy-related myocardial disease. PPCM has a high morbidity and mortality rate, but neither partial nor complete recovery is highly probable. Objective: To analyze global scientific production and identify research hotspots related to PPCM. Methods: The keyword “peripartum cardiomyopathy” was used to retrieved articles from Scopus database. A total of 509 articles were extracted. We used Scopus database analysis report and VOSviewer (version 1.6.18) to analyze annual publication number, country, citation and H-index, authors, institution, source journal, reference, and research hotspot. Results: The trend of annual publication numbers has increased significantly, with the United States leading the amounts of publication and H-index in PPCM study. Hilfiker-Kleiner, D. contributed the most publications and the most active institution was Medizinische Hochschule Hannover MHH. By employing an overlay visualization, we shed light on the evolving research emphases, wherein prominent topics such as “diagnostic imaging” and “practical guidelines” have emerged as major areas of focus in recent years. Conclusion: From 1971 to 2022, numbers of publications in PPCM research have increased gradually, and this trend is predicted to keep arising. Recent studies are becoming more focused on diagnostic imaging and practical guidelines. In the future, expanding global collaboration and conducting more in-depth studies are needed.

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Peripartum Cardiomyopathy

Cited by 2 publications

References 187 publications

Recent Findings on Hyperprolactinemia and its Pathological Implications: A Literature Review

Recent Findings on Hyperprolactinemia and its Pathological Implications: A Literature Review

Global Research Trends and Future Direction in Peripartum Cardiomyopathy: A Bibliometric Analysis

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