Global Research Trends and Future Direction in Peripartum Cardiomyopathy: A Bibliometric Analysis

Wijayanto, Matthew; Lukas, Graciella; Greatalya, Lawly; Ilyas, Muhana; Myrtha, Risalina

doi:10.5455/aim.2023.31.270-274

Cited by 1 publication

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References 24 publications

(29 reference statements)

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“…While pregnancy induces major alterations in haemodynamic that result in a significant increase in cardiac workload, recent studies have found that vascular dysfunction and cardiomyocyte apoptosis induced by late-gestational maternal hormones have been implicated as the primary causes of PPCM. 29 34 This could be attributed to the higher likelihood of LV dysfunction occurring in PPCM as opposed to RV and diastolic dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of subsequent pregnancy in women with peripartum cardiomyopathy: a systematic review and meta-analysis

Wijayanto,

Myrtha,

Lukas

et al. 2024

Open Heart

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IntroductionThe primary concern for women who have experienced peripartum cardiomyopathy (PPCM) is the safety of a subsequent pregnancy (SSP). To maximie decision-making, facilitate effective patient counselling, and ultimately improve maternal and fetal outcomes as a whole, it is critical to comprehend the outcomes of SSP in women who have previously experienced PPCM. This study aimed to evaluate the outcomes of SSP in women with PPCM.MethodsThree databases (PubMed, Scopus, and ScienceDirect) were used to identify relevant studies prior to 17 October 2023. A total of 662 studies were reviewed. Following the abstract and full-text screenings, 18 observational studies were included, out of which 2 were deemed suitable for inclusion in this meta-analysis. The quality assessment was conducted using the Newcastle-Ottawa Scale.ResultsThis study has a total of 487 SSPs. Although recovered left ventricular (LV) function before entering SSP has the potential to be a beneficial prognostic factor, recovered LV function still has a substantial risk of relapse. The mortality rate of PPCM in an SSP ranged from 0% to 55.5%. Persistent LV dysfunction was significantly associated with an increased mortality rate (OR 13.17; 95% CI 1.54 to 112.28; p=0.02) and lower LV ejection fraction (MD −12.88; 95% CI −21.67 to −4.09; p=0.004). Diastolic and right ventricular functions remained unchanged before SSP and at follow-up. The majority of the SSP was observed alongside hypertension, while pre-eclampsia emerged as the predominant hypertensive complication in most studies.ConclusionSSP increases the risk of relapse and mortality in women with a previous history of PPCM. Persistent LV dysfunction prior to the SSP has a higher mortality risk compared with recovered LV function. SSP was also associated with the worsening of LV echocardiography parameters.

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Section: Discussionmentioning

confidence: 99%