Peripapillary Vessel Density Measured by Optical Coherence Tomography Angiography in Idiopathic Intracranial Hypertension

Bilen, Feyza Tüntaş; Atilla, Hüban

doi:10.1097/wno.0000000000000745

Cited by 22 publications

(21 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, there are some discrepancies between the quantitative OCTA studies on optic disc swelling. Indeed, Tüntaş Bilen and Atilla 9 have found a decrease in peripapillary vasculature in eyes with papilledema while Fard et al 5 have not found any differences between eyes with papilledema and control eyes. Furthermore, if all these studies were conducted on a RNFL segmentation basis, in one study 8 the quantification was made on a segmentation including both RNFL and GCL.…”

Section: Introductionmentioning

confidence: 98%

OCT angiography analysis in acute non-arteritic anterior ischemic optic neuropathy: The importance of segmentation

Rougier

Gattoussi²,

Goff

et al. 2020

European Journal of Ophthalmology

View full text Add to dashboard Cite

Background: In non-arteritic anterior ischemic optic neuropathy (NAION), optical coherence tomography angiography (OCTA) shows changes in peripapillary vascularization. However, the presence of an optic disc edema may induce artifacts that prevent visualizing the peripapillary network. The aim of this study was to evaluate the peripapillary vascularization in acute NAION using swept-source OCTA algorithms allowing segmenting only the retinal nerve fiber layer (RNFL). Methods: Retrospective analysis of 15 eyes with acute NAION of 15 patients. The optic nerve head was imaged using swept-source OCTA. Morphological and quantitative analyzes were performed. The capillary flux index (CFI), defined as the total weighted area of perfused vasculature per unit area, and the capillary perfusion density (CPD), defined as the total area of perfused microvasculature per unit area, were quantified. Each NAION eye was compared to the unaffected fellow eye using a Wilcoxon test for matched samples. Results: After segmentation at the RNFL, the morphological analysis showed less vascular dropout and more vascular tortuosity than the analysis of a larger segmentation. The quantitative analysis showed that the mean CFI and the CFI in the four quadrants were significantly higher in NAION eyes compared to healthy eyes ( p = 0.0002 and p < 0.01). The mean CPD and the CFD in the inferior quadrant were lower in NAION eyes ( p = 0.03 and p = 0.0054, respectively). Discussion: The RNFL segmentation allowed better visualizing the peripapillary network because the edema related darkening was reduced. The increased CFI suggests an autoregulatory phenomenon to compensate the ischemic process at the ciliary vasculature.

show abstract

Section: Introductionmentioning

confidence: 98%

OCT angiography analysis in acute non-arteritic anterior ischemic optic neuropathy: The importance of segmentation

Rougier

Gattoussi²,

Goff

et al. 2020

European Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…In subgroup analysis, they reported signi cantly higher mean RPC vessel densities in patients with low-grade (grade 1 and 2) papilledema compared with patients with high-grade (grade 3 and 4) papilledema [4]. Parallel to these ndings, an inverse correlation between RPC density and papilledema grade was observed by Torres et al [8] and Tüntaş Bilen et al [9] In the latter study, although a signi cant decrease was observed in the peripapillary vessel density of eyes with papilledema of IIH patients compared with controls, similar peripapillary vessel densities were detected between the controls and IIH patients without papilledema [9].…”

Section: Discussionmentioning

confidence: 67%

Evaluation of Retinal Vascular and Structural Alterations in Pediatric Idiopathic Intracranial Hypertension Patients without Papilledema

Yılmaz

Ateşoğlu

Turkay³

et al. 2023

Preprint

View full text Add to dashboard Cite

Purpose The aim of this study was to evaluate retinal structural and microvascular alterations using optical coherence tomography-angiography (OCTA) in pediatric idiopathic intracranial hypertension (IIH) patients with regressed papilledema. Methods This study included 40 eyes of 21 IIH patients and 69 eyes of 36 healthy controls. Radial peripapillary capillary (RPC) vessel density and peripapillary retinal nerve fiber layer (RNFL) thickness were evaluated by XR Avanti AngioVue OCTA (Optovue, Fremont, CA, USA). The data were obtained from measurement zones that are automatically divided into two equal hemispheres (superior and inferior) and eight quadrants (superior-temporal, superior-nasal, inferior-temporal, inferior-nasal, nasal-superior, nasal-inferior, temporal-superior, temporal-inferior). Initial cerebrospinal fluid (CSF) pressure, grade of papilledema, and duration of follow-up were recorded. Results There were significant differences in RPC vessel densities and RNFL thicknesses between the study groups (p ˃ 0.05). Significantly higher RPC vessel density measurements were observed in the patient group for the whole image, peripapillary, inferior-hemi, and whole nasal quadrants (p < 0.05). Except for the temporal-superior, temporal-inferior, inferior-temporal, and superior-temporal quadrants, the RNFL in all regions was significantly thicker in the IIH group than in the control group (p ˂ 0.001). Conclusions RNFL thickness and RPC vessel density were significantly different between the IIH patient and control groups, suggesting that retinal microvascular and subclinical structural changes that were potentially secondary to CSF pressure can persist after the resolution of papilledema. However, our results should be confirmed by further longitudinal studies investigating the progress of these alterations to determine their effects on peripapillary tissues.

show abstract

“…We might have expected an increase in VD postoperatively after the removal of axonal compression, but this was not observed in the present case series, we found the opposite. Postoperative disc swelling may have gone undetected and could lead to changes in VD, as was previously described in other studies [ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 69%

Peripapillary Microvascularization Analysis Using Swept-Source Optical Coherence Tomography Angiography in Optic Chiasmal Compression

Ghezala

Haddad

Blanc

et al. 2021

Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose. To evaluate the vessel density (VD) of the radial peripapillary capillary (RPC) network using swept-source optical coherence tomography angiography (SS-OCTA) “en face” images of eyes with chiasmal compression caused by brain tumors before and after decompressive surgery compared with healthy controls. Methods. A cross-sectional study was conducted in 12 patients with chiasmal compression confirmed by neuroimaging. Sixteen healthy participants were also included. All patients with chiasmal compression underwent a neuro-ophthalmological examination one week before and 6 months after brain surgery, including static automated perimetry as well as measurement of the thickness of the retinal nerve fiber layer (RNFL) and the ganglion cell complex (GCC) with spectral-domain optical coherence tomography (SD-OCT). Based on this neuro-ophthalmological examination, the presence of an optic neuropathy (ON) was evaluated. Peripapillary VD was obtained in four sectors on a 6 × 6 mm SS-OCTA image using the Cirrus Plex Elite 9000. Results. Baseline average VD was significantly lower in patients with chiasmal compression and ON than in controls (median: 55.62; interquartile range (IQR): 2.96 vs. 58.53; IQR: 2.02; p = 0.003 ). This decrease was also found in the temporal, superior, and nasal sectors. Average postoperative VD was decreased in patients with chiasmal compression compared with average preoperative VD (median: 56.16; IQR: 4.07 vs. 57.48; IQR: 3.83; p = 0.004 ). Preoperative VD was significantly correlated with RNFL, GCC thickness, and visual field defects. Conclusions. The VD of the RPC network was decreased in chiasmal compressive ON, and it was further decreased at 6 months after decompressive surgery.

show abstract

Peripapillary Vessel Density Measured by Optical Coherence Tomography Angiography in Idiopathic Intracranial Hypertension

Cited by 22 publications

References 14 publications

OCT angiography analysis in acute non-arteritic anterior ischemic optic neuropathy: The importance of segmentation

OCT angiography analysis in acute non-arteritic anterior ischemic optic neuropathy: The importance of segmentation

Evaluation of Retinal Vascular and Structural Alterations in Pediatric Idiopathic Intracranial Hypertension Patients without Papilledema

Peripapillary Microvascularization Analysis Using Swept-Source Optical Coherence Tomography Angiography in Optic Chiasmal Compression

Contact Info

Product

Resources

About