Perioral contact urticaria from sodium benzoate in a toothpaste

Muñoz, Francisco José; Bellido, J.; Moyano, J. C.; Álvarez, María José; Fonseca, J. L.

doi:10.1111/j.1600-0536.1996.tb02272.x

Cited by 17 publications

(9 citation statements)

References 7 publications

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“…Perioral dermatitis based on contact allergy is diagnosed after exclusion of the earlier mentioned common causes. Dental fillings, toothpaste, and rosin in chewing gum were reported as causes of sensitization (63)(64)(65)(66).…”

Section: Perioral and Perianal Dermatitismentioning

confidence: 99%

Allergic contact dermatitis in children: which factors are relevant? (review of the literature)

Spek

Andersen

Darsow

et al. 2013

Pediatric Allergy Immunology

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Allergic Contact Dermatitis (ACD) in children is increasing. Sensitization to contact allergens can start in early infancy. The epidermal barrier is crucial for the development of sensitization and elicitation of ACD. Factors that may influence the onset of sensitization in children are atopic dermatitis, skin barrier defects and intense or repetitive contact with allergens. Topical treatment of ACD is associated with cutaneous sensitization, although the prevalence is not high. ACD because of haptens in shoes or shin guards should be considered in cases of persistent foot eruptions or sharply defined dermatitis on the lower legs. Clinical polymorphism of contact dermatitis to clothing may cause difficulties in diagnosing textile dermatitis. Toys are another potentially source of hapten exposure in children, especially from toycosmetic products such as perfumes, lipstick and eye shadow. The most frequent contact allergens in children are metals, fragrances, preservatives, neomycin, rubber chemicals and more recently also colourings. It is very important to remember that ACD in young children is not rare, and should always be considered when children with recalcitrant eczema are encountered. Children should be patch-tested with a selection of allergens having the highest proportion of positive, relevant patch test reactions. The allergen exposure pattern differs between age groups and adolescents may also be exposed to occupational allergens. The purpose of this review is to alert the paediatrician and dermatologist of the frequency of ACD in young children and of the importance of performing patch tests in every case of chronic recurrent or therapyresistant eczema in children.Allergic contact dermatitis (ACD) in children is increasing (1). Sensitization to contact allergens may already begin at an early age. The data on prevalence of contact allergy among children visiting dermatology clinics vary between 15% and 71% (2-5). Patch testing is the gold standard diagnostic test (6, 7).

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Section: Perioral and Perianal Dermatitismentioning

confidence: 99%

Allergic contact dermatitis in children: which factors are relevant? (review of the literature)

Spek

Andersen

Darsow

et al. 2013

Pediatric Allergy Immunology

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“…Excess consumption of this substance could decrease the ability of the immune system to function properly and also cause other irritations (Science Lab, 2013e;Munoz, Bellido, Moyano, Alvarez, & Fonseca, 1996).…”

Section: Preservatives Propylparabenmentioning

confidence: 99%

Ingredients in Children’s Fluoridated Toothpaste: A Literature Review

Basch

Kernan

2016

GJHS

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Children's fluoridated toothpastes are supplemented with ingredients intended to increase appeal. A comprehensive list of children's toothpastes and their ingredients was compiled from nine pharmacies in New York City. A broad literature review was then conducted to describe the purpose of the ingredient and the known contamination risks associated with chronic consumption of each ingredient. The final sample size comprised 26 children's toothpastes and 45 unique ingredients. The purpose and known contamination risks of the 45 identified ingredients were documented. A proportion of ingredients (28.9% [n = 13]) were found to be both unnecessary to improving the oral health of children and solely used to increase their appeal. Of this list of unnecessary ingredients, 69.2% (n = 9) were shown to have contamination risks associated with chronic consumption, including enamel demineralization. The authors recommend that toothpaste manufacturing practices be limited to include only ingredients that are necessary for improved oral health and care and only using natural flavorings when needed.

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“…In the literature cases of cheilitis and perioral contact urticaria have been described, caused by sodium benzoate present in toothpaste, as demonstrated by patch test positivity 5,6 . The respiratory tract can also be the target of sodium benzoate hypersensitivity.…”

mentioning

confidence: 99%

“…4 In the literature cases of cheilitis and perioral contact urticaria have been described, caused by sodium benzoate present in toothpaste, as demonstrated by patch test positivity. 5,6 The respiratory tract can also be the target of sodium benzoate hypersensitivity. This additive has been evaluated for its role in asthma, although the exact prevalence is again unknown because of the bias that affected the studies.…”

mentioning

confidence: 99%