Perioperative Systemic Lidocaine for Postoperative Analgesia and Recovery after Abdominal Surgery

Ying, Sun; Li, Tianzuo; Wang, Nan; Yue, Yun; Gan, Tong J.

doi:10.1097/dcr.0b013e318259bcd8

Cited by 202 publications

(145 citation statements)

References 44 publications

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“…The association between number of analgesics and lidocaine administrations was statistically significant (P = 0.01). Patients in the lidocaine group were 4 Iran Red Crescent Med J. In Press(In Press):e14531.…”

Section: Resultsmentioning

confidence: 99%

“…Research is ongoing to introduce better alternatives for opioids after surgical procedures. Systemic lidocaine has generally been shown to be beneficial after open surgeries, while more research would be of help to construct more solid evidence for laparoscopic operations in field of gynecology (4)(5)(6)(7). This is while pain pattern and management after medical procedures is highly dependent on type of procedure, anatomical location, and pathological conditions related to the disease itself.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Intravenous Infusion of Lidocaine to Control Postoperative Pain After Gynecologic Laparoscopic Surgery: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Moslemi

Rasooli

Dehdilani

et al. 2017

Iran Red Crescent Med J

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Background: Pain after laparoscopy may still be moderate to severe due to stretching of intraabdominal cavity and peritoneal inflammation. Systemic lidocaine with anti-inflammatory properties may reduce this pain. Objectives: The aim of this study was to evaluate the effect of perioperative intravenous infusion of lidocaine on postoperative pain relief after gynecologic laparoscopic procedure. Methods: A double-blind randomized clinical trial study was conducted in Iran, during years 2014 and 2015. A sample of 60 females with American anesthesiology association (ASA) physical class I or II, who were scheduled for gynecologic laparoscopy were selected through consecutive sampling and were randomly assigned to receive either intravenous lidocaine or normal saline, as placebo, prior to induction of anesthesia and until the end of surgery. Severity of postoperative pain was evaluated starting at the recovery unit until 24 hours postoperatively for a total of 8 times using the visual analogue scale (VAS) scoring system. Time to first analgesic request, total analgesic dose used in the first 24 hours, and any probable postoperative complications were recorded. Risk ratio (RR) and number needed to treat (NNT) were used to analyze the data along with generalized linear model for multivariate analysis of repeated measurements over time. Results: The VAS at recovery was lower at recovery with a mean score of 2.8 in the lidocaine group versus 3.9 in the control group (P = 0.02). Results of generalized linear modelling revealed that pain intensity decreased over time in both groups (P = 0.02), and the groups had different trend slopes in pain intensity over repeated measurements at various time points up to 24 hours after laparoscopy, while controlling for the baseline VAS at recovery and ASA PS (P = 0.016). However, when controlling for use of painkillers, the trends were not found to be different. Patients in the lidocaine group were 3.8 times more likely not to need postoperative analgesic (95% CI: 1.4 to 9.9). Mean total analgesic dose was 1.3 mg in the lidocaine group versus 38.2 mg in the control group differing significantly between the 2 groups (P < 0.01). Use of lidocaine was associated with lower postoperative nausea and agitation. Conclusions: Systemic perioperative lidocaine could improve the pain pattern and severity as well as nausea and agitation after gynecologic laparoscopy. Although no major side effects were detected in this study, the benefits of the intervention should be weighed against its safety.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effect of Intravenous Infusion of Lidocaine to Control Postoperative Pain After Gynecologic Laparoscopic Surgery: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Moslemi

Rasooli

Dehdilani

et al. 2017

Iran Red Crescent Med J

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“…Perioperative IV administration of lignocaine also has a preventive analgesic effect following a wide range of operations. [9][10][11] Currently there is no literature about this perioperative pain control modality in the Chinese patients. In the following account, we present a case series of Chinese patients who underwent laparoscopic colorectal surgery and received a perioperative IV lignocaine infusion.…”

Section: Discussionmentioning

confidence: 99%

Intravenous lignocaine infusion facilitates acute rehabilitation after laparoscopic colectomy in the Chinese patients

Lee

Or²,

Tsang³

et al. 2017

Hong Kong Med J

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“…Novo indikaciono područje za primenu lidokaina je prevencija postoperativnog ileusa i postoperativne mučnine koji su se pokazali kao značajani faktori kvaliteta postoperativnog oporavka i trajanja hospitalizacije 31,32 . Međutim, polemika se vodi oko indikacije za ovu primenu.…”

Section: Lidokainunclassified

Old drugs are new again (drugs)

Jovičić¹,

Gvozdić²,

Volaš³

et al. 2017

Serb J Anes Inten Therap

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Sažetak UvodS obzirom na to da je akutni bol praiskonski zaštit-ni simptom, a da je hronični bol označen kao bolest savremenog čoveka, zbrinjavanje obe vrste bola, prema Montrealskoj deklaraciji, predstavlja osnovno pravo svakog čoveka i etički imperativ 1 . U eri dobro razvijene farmaceutske industrije, postoji ogroman pritisak društva za proizvodnju novih grupa farmakoloških sredstava u cilju tretiranja bolnih stanja.Osnovna mana novih grupa lekova je nedovoljno poznati spektar neželjenih dejstava, koji se otkriva nakon dovoljno duge upotrebe u praksi. Kako navodi Pharmacy Times iz 2011. godine 2 , za dobijanje odobrenja od Federal drug administration (FDA) za plasiranje novog leka na tržište, potrebno je ogromno finansijsko ulaganje i prelazak dugog puta u sprovođenju pretkliničkih i kliničkih istraživanja. Na primer, 1996. godine, 53% podnetih zahteva za sprovođenje kliničkog istraživanja bilo je odobreno od strane FDA, za razliku od 19% zahteva koliko je bilo podržano 2009. godine 3 . Taj trend se i dalje održava. Ono što je preporuka ovih autora je da se stari, već dobro poznati farmakološki profil lekova proširi novim indikacionim područjem (eng. prepurposing) i da se poznate farmakokinetske i farmakodinamske osobine iskoriste za unapređenje formulacije leka (eng. preformulation). Kroz navedena dva procesa, prolaze neki od najmoćnih medikamenata iz palete multimodalnog pristupa terapiji bola.Kako navode Wu i saradnici, multimodalni pristup lečenju akutnog postoperativnog bola, koji obuhvata i upotrebu modulatora bola, terapijski je pristup koji bi poboljšao kontrolu bola i smanjio potrebu za primenom opioida 4 . Međutim, problematika koju ističu ovi autori se odnosi na širok dijapazon primenjenih doza istog leka, kombinaciju različitih tehnika u različitoj vrsti hirurgije, a sve to ne stvara podlogu za formiranje jednog konzistentnog zaključka. Nasuprot ovom podatku, u tertmanu hroničnog nemalignog bola, primena multimodalnog pristupa i modulatora bola je neophodan terapijski pristup s obzirom na komplek-

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Perioperative Systemic Lidocaine for Postoperative Analgesia and Recovery after Abdominal Surgery

Abstract: Perioperative systemic lidocaine may be a useful adjunct for postoperative pain management by decreasing postoperative pain intensity, reducing opioid consumption, facilitating GI function, and shortening length of hospital stay.

Cited by 202 publications

References 44 publications

The Effect of Intravenous Infusion of Lidocaine to Control Postoperative Pain After Gynecologic Laparoscopic Surgery: A Randomized Double-Blind Placebo-Controlled Clinical Trial

The Effect of Intravenous Infusion of Lidocaine to Control Postoperative Pain After Gynecologic Laparoscopic Surgery: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Intravenous lignocaine infusion facilitates acute rehabilitation after laparoscopic colectomy in the Chinese patients

Old drugs are new again (drugs)

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