Perioperative cytokine response after liver transplantation

Lee, K.W; Son, Taeyoung; Joh, Jae‐Won; Kim, S.J; Park, J.H; Chon, Seong Eun; Choi, Sooin; Heo, Jin Seok; Kim, Y.I; Lee, B.B; Lee, S.K

doi:10.1016/s0041-1345(02)03956-8

Cited by 7 publications

(8 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mueller et al (16) also reported that several cytokines secreted during liver transplantation, including IL-2, were correlated with postoperative graft function. The proposed mechanism is excessive secretion of cytokines, promoting graft inflammation, resulting in a loss of graft function (17). Thus, it seems likely that the CTP classification or the MELD score, which are used to predict survival after liver transplantation, may also be useful in estimating the severity of the systemic inflammatory reaction, which is measured in terms of plasma cytokine concentrations.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that cytokine concentrations in patients undergoing liver transplantations can be used to predict the graft prognosis (14-17). This suggests that the CTP classification or the MELD score may be useful in assessing the degree of systemic inflammatory reaction in liver transplantation patients by measuring cytokine concentrations.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of the Child-Turcotte-Pugh Classification and the Model for End-stage Liver Disease Score as Predictors of the Severity of the Systemic Inflammatory Response in Patients Undergoing Living-donor Liver Transplantation

et al. 2011

View full text Add to dashboard Cite

The aim of this study was to evaluate and compare the Child-Turcotte-Pugh (CTP) classification system and the model for end-stage liver disease (MELD) score in predicting the severity of the systemic inflammatory response in living-donor liver transplantation patients. Recipients of liver graft were allocated to a recipient group (n = 39) and healthy donors to a donor group (n = 42). The association between the CTP classification, the MELD scores and perioperative cytokine concentrations in the recipient group was evaluated. The pro-inflammatory cytokines measured included interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α; the anti-inflammatory cytokines measured included IL-10 and IL-4. Cytokine concentrations were quantified using sandwich enzyme-linked immunoassays. The IL-6, TNF-α, and IL-10 concentrations in the recipient group were significantly higher than those in healthy donor group patients. All preoperative cytokine levels, except IL-6, increased in relation to the severity of liver disease, as measured by the CTP classification. Additionally, all cytokine levels, except IL-6, were significantly correlated preoperatively with MELD scores. However, the correlations diminished during the intraoperative period. The CTP classification and the MELD score are equally reliable in predicting the severity of the systemic inflammatory response, but only during the preoperative period.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of the Child-Turcotte-Pugh Classification and the Model for End-stage Liver Disease Score as Predictors of the Severity of the Systemic Inflammatory Response in Patients Undergoing Living-donor Liver Transplantation

et al. 2011

View full text Add to dashboard Cite

show abstract

“…IR injury is induced not only by toxic responses to oxygen-derived free radicals but also by immune responses, including the release of inflammatory mediators such as cytokines [20]. These cytokine responses have an important effect on the survival of allografts in patients undergoing LT [21][22][23][24][25]. Thus, the suppression of harmful cytokine responses related to IR injury by inducing immunomodulation is an important approach for improving patient outcome.…”

Section: Discussionmentioning

confidence: 99%

Effects of magnesium pretreatment on the levels of T helper cytokines and on the severity of reperfusion syndrome in patients undergoing living donor liver transplantation

Chung¹,

Park²,

Hong³

et al. 2013

Magnesium Research

View full text Add to dashboard Cite

Objectives: Magnesium has protective effects in ischaemiareperfusion injury, and is involved in immunomodulation. We investigated the effects of magnesium pretreatment on the secretion of T helper (Th) cytokines and on the severity of post-reperfusion syndrome (PRS) in patients undergoing living donor liver transplantation (LDLT). Methods: forty patients were allocated to two groups of 20 (magnesium and saline groups). Blood samples for cytokine analysis were collected before infusion of the study solution at the end of anhepatic phase (time point 1), as well as five min and 30 min after allograft reperfusion (time points 2 and 3, respectively). Levels of cytokines were quantified using a sandwich enzyme immunoassay test kit. Results: The duration of PRS was shorter in the magnesium group (p = 0.038). The level of interferon (IFN)-␥ released from Th1 was lower in the magnesium group at time point 3 (p = 0.009). Of the cytokines released from Th2 cells, interleukin (IL)-6 was present in higher concentrations in the magnesium group at time points 2 and 3 (p<0.05). The concentrations of IL-4 and IL-10, which were secreted from Th2 cells, were also higher in the magnesium group at time point 3 (p<0.05). The IFN-␥ /IL-6, IFN-␥ /IL-4 and IFN-␥ /IL-10 ratios were lower in the magnesium group after allograft reperfusion. Conclusions: Magnesium pretreatment attenuated PRS and reinforced Th2 cell activity, shifting the Th1-to-Th2 cytokine balance towards Th2 in patients undergoing LDLT.

show abstract

“…There are various factors that influence the secretion of cytokines in end-stage liver failure patients in need of liver transplantation surgery, which include severity index of liver disease, amount of intraoperative transfusion and hemodynamic parameters during surgery 4, 5, 16-19.…”

Section: Factors Influencing the Concentration Of Cytokines During LImentioning

confidence: 99%

“…There are evidences that the amount of transfusion during liver transplantation surgery affects cytokines secretion. Lee et al 16 stated that the amount of intraoperative transfusion was positively related with IL-6 concentration of postoperative day 7 (r2 = 0.718, P = 0.013). As a result of tracking serial changes in the IL-6 concentration, Miki et al 17 stated that patients whose operative blood transfusion requirement was 10 unit of packed red cell or more showed higher IL-1, IL-6 and TNF-alpha concentrations after graft reperfusion, and concluded that increased blood loss induced increased pro-inflammatory cytokines.…”

Section: Factors Influencing the Concentration Of Cytokines During LImentioning

confidence: 99%

Pathophysiologic Implications of Cytokines Secretion during Liver Transplantation Surgery

Hwang

Lee

2018

Int. J. Med. Sci.

View full text Add to dashboard Cite

We introduce the following issues of the cytokines secretion during liver transplantation surgery in this review article; 1) the aspect of cytokines secretion during liver transplantation surgery, 2) the evidences of association of cytokines concentration with post-transplantation graft survival, 3) a variety of factors that may influence the secretion of cytokines during liver transplantation, 4) pro-inflammatory and anti-inflammatory cytokine balance during the surgery, and 5) the issues of T helper 1 and T helper 2, and T helper 17 and regulatory T cell signature cytokines secretion and their ratio during liver transplantation surgery. Primary failure of the liver is associated with the secondary dysfunction of virtually all other organ systems, including the cardiovascular, pulmonary, renal, coagulation and central nervous systems. In addition, liver transplantation surgery itself is a major surgical procedure with accompanying life-threatening hemorrhage, massive transfusion, clamping and unclamping of great vessels and resulting ischemia-reperfusion injury and cardiovascular instability. Both the underlying liver failure and the surgical events act as stressors and promote the secretion of various cytokines. So it is clinically important to understand above issues regarding the cytokines secretion during liver transplantation surgery. As cytokines secretion has clear relationship with post-transplantation clinical outcomes, future study directions for artificially manipulating cytokines secretion is also suggested for enhancing outcomes of the patients.

show abstract

Perioperative cytokine response after liver transplantation

Cited by 7 publications

References 5 publications

Comparison of the Child-Turcotte-Pugh Classification and the Model for End-stage Liver Disease Score as Predictors of the Severity of the Systemic Inflammatory Response in Patients Undergoing Living-donor Liver Transplantation

Comparison of the Child-Turcotte-Pugh Classification and the Model for End-stage Liver Disease Score as Predictors of the Severity of the Systemic Inflammatory Response in Patients Undergoing Living-donor Liver Transplantation

Effects of magnesium pretreatment on the levels of T helper cytokines and on the severity of reperfusion syndrome in patients undergoing living donor liver transplantation

Pathophysiologic Implications of Cytokines Secretion during Liver Transplantation Surgery

Contact Info

Product

Resources

About