The ability of noninvasive imaging modalities to di· agnose lower extremity DVT depends, in part, on the anatomic location of the thrombus. To define the pattern of thrombus formation in symptomatic and asymptomatic high-risk patient populations, 172 con• secutive lower extremity venograms were submitted to blinded, retrospective interpretation. Acute DVT was present in 59 venograms (34 symptomatic and 25 asymptomatic patients).Among symptomatic patients with acute DVT, 26 of 34 (76%) patients had an above-knee thrombus and only eight of 34 (24%) patients had a thrombus isolated to the calf. In comparison, only three of 25 (12%) asymptomatic patients with DVT had an above-knee thrombus and 22 of 25 (88%) patients had a thrombus L ower extremity DVT is a common disorder that may have serious consequences in the form of a pulmonary embolism or lower extremity chronic venous insufficiency. The distribu-ABBREVIATIONS DVI', Deep venous thrombosis