Perioperative analgesia with intraoperatively started infusion of high-dose dipyrone in orthopaedic and trauma surgery

Bradycardia and hypotension associated with fomepizole infusion during hemodialysis

“…These cases have presented both with (21) and without (22) other symptoms of allergic reaction such as bronchospasm or generalized skin rash. Studies of intravenous metamizol in surgical or critically ill patients have shown variable cardiovascular effects, ranging from no significant differences versus comparison group(s) to transient hypotension (23)(24)(25)(26)(27)(28). In one series of critically ill, febrile patients, metamizol infusion reduced MAP by an average of 10 mmHg at two hours post-infusion, with recovery to baseline by four hours (24).…”

Metamizole: A Review Profile of a Well-Known “Forgotten” Drug. Part II: Clinical Profile

“…Quality of analgesia was improved with a significant reduction in the visual analogue scores (VAS) (P < 0.006) and the doses of opioids required (P < 0.0001), with no additional side effects. This trial showed a highly significant reduction of the first pain score after arrival in the recovery room in the metamizole group, with a significant reduction of subsequent requirements for rescue analgesia by opioid injection (21). the fact that typical toxic effects of nSAiDs such as compromised renal, hepatic and gastrointestinal function do not occur with metamizole use and as the risk of agranulocytosis linked to its use is extremely low, the substance offers advantages over nSAiDs.…”

Postoperative Analgesie mit Tramadol und Metamizol

“…So fand dieses Konzept auch Eingang in die postoperative Schmerztherapie. Zahlreiche Studien belegen eine deutliche Einsparung von Opioiden und damit eine Verringerung potenziell schwerer opioidbedingter Komplikationen bei der zusätzlichen Applikation von Nichtopioiden [3,12,27,28,30].Opioideinsparungen von 67% beschreiben Steffen et al [28] durch perioperativ verabreichtes Metamizol und weitere Metamizolinfusionen im 6-stündigen Abstand nach endoskopischen abdominellen Eingriffen.…”