Periodontopathic Bacteria and Their Potential Involvement in Atherosclerosis

Kuramitsu, Howard K.

doi:10.5466/ijoms.1.1

Cited by 5 publications

(4 citation statements)

References 41 publications

(33 reference statements)

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“…Incubation of whole blood with the oral pathogen P. gingivalis results in proteolysis of ApoB-100 [160]. Other investigators have demonstrated degradation of ApoB-100 by intact P. gingivalis , its LPS, or outer membrane vesicles from the organism [161,162]. Similar modifications are observed when P. gingivalis is administered to ApoE −/− mice [163], suggesting that these modifications may be of physiological significance.…”

Section: Periodontal Disease Lipoproteins and Lipoprotein Metabolismmentioning

confidence: 92%

Lipoproteins and lipoprotein metabolism in periodontal disease

Griffiths

Barbour

2010

Clinical Lipidology

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A growing body of evidence indicates that the incidence of atherosclerosis is increased in subjects with periodontitis -a chronic infection of the oral cavity. This article summarizes the evidence that suggests periodontitis shifts the lipoprotein profile to be more proatherogenic. LDL-C is elevated in periodontitis and most studies indicate that triglyceride levels are also increased. By contrast, antiatherogenic HDL tends to be low in periodontitis. Periodontal therapy tends to shift lipoprotein levels to a healthier profile and also reduces subclinical indices of atherosclerosis. In summary, periodontal disease alters lipoprotein metabolism in ways that could promote atherosclerosis and cardiovascular disease.

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Section: Periodontal Disease Lipoproteins and Lipoprotein Metabolismmentioning

confidence: 92%

Lipoproteins and lipoprotein metabolism in periodontal disease

Griffiths

Barbour

2010

Clinical Lipidology

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“…In contrast, another study (Hujoel et al , 2000), found no epidemiologic relationship between periodontal disease and heart disease. Many researchers have already reviewed the relationship between oral bacteria and vascular diseases (Herzberg et al , 1997; Herzberg and Weyer, 1998; Okuda and Ebihara, 1998; Paquette et al , 1999; Pallasch and Slots, 2000; Slavkin and Baum, 2000; Kuramitsu et al , 2001; Slots and Kamma, 2001; Genco, Offenbacher and Beck, 2002; Kuramitsu, 2002).…”

Section: Detection Of Periodontopathic Bacteria In Samples Of Stenotimentioning

confidence: 99%

Involvement of periodontopathic biofilm in vascular diseases

2003

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Oral bacteria inhabit biofilms, which are firm clusters adhering in layers to surfaces and are not easily eliminated by immune responses and are resistant to antimicrobial agents. Dental plaque is one such biofilm. In the past 10 years, subgingival plaque bacteria forming biofilms have been increasingly reported to be involved in systemic diseases. A close relationship between microbial infections and vascular disease has also been reported in the past two decades. The present review discusses the significance of the ecologic characteristics of biofilms formed by periodontopathic bacteria in order to further clarify the associations between periodontal disease and systemic disease. We focus on the relationships between periodontal disease-associated bacteria forming biofilms and vascular diseases including atherosclerosis and carotid coronary stenotic artery disease, and we discuss the direct and indirect effects on vascular diseases of lipopolysaccharides as well as heat shock proteins produced by periodontopathic bacteria.

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“…), and Eikenella corrodens (E. c.) for systemic diseases has recently become an important topic in periodontal medicine. There are many reports of the association of these periodontopathic bacteria with CVD and stroke [3][4][5][6][7][8][9][10]. Periodontitis is associated with elevated levels of markers of inflammation that are indicators of CVD and stroke risk.…”

Section: Introductionmentioning

confidence: 99%

The Usefulness of Evaluation of IgG Antibodies against Periodontopathic Bacteria for Prediction of Vascular Disease

Ito¹

2014

J Cardiovasc Dis Diagn

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and written consent was obtained from all patients or their appointed representatives.Sixty patients who had medical examination in the emergency department of the hospital from January to December 2009 were prospectively analyzed in this study (patients were randomly selected and were not consecutive). The diseases, which were the reason why patients visited or were transferred to emergency room of this hospital, are shown in Table 1.We used DEMECAL blood examination system (Sunstar Direct Dental Supply, Osaka, Japan) to measure the levels of immunoglobulin (Ig) G antibodies to periodontopathic bacteria such as P. g., A. a., P. i., and E. c. in the patients' blood. A feature of this system is that only a small volume of whole blood (about 50 µL) is required for

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Periodontopathic Bacteria and Their Potential Involvement in Atherosclerosis

Cited by 5 publications

References 41 publications

Lipoproteins and lipoprotein metabolism in periodontal disease

Lipoproteins and lipoprotein metabolism in periodontal disease

Involvement of periodontopathic biofilm in vascular diseases

The Usefulness of Evaluation of IgG Antibodies against Periodontopathic Bacteria for Prediction of Vascular Disease

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