Periodontitis, periodontopathic bacteria and lactoferrin

Wakabayashi, Hiroyuki; Kondo, Isamu; Kobayashi, Tetsuo; Yamauchi, Koji; Toida, Tomohiro; Iwatsuki, Keiji; Yoshie, Hiromasa

doi:10.1007/s10534-010-9304-6

Cited by 47 publications

(45 citation statements)

References 36 publications

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“…Periodontal diseases are associated with inflammation in tissue surrounding the tooth, due to the accumulation of subgingival plaque formed mainly by Gram-negative bacteria (Wakabayashi et al, 2010;. A new method of treating periodontal disease uses bovine LF (1) inhibiting the inflammatory process by binding free iron ions, (2) binding to the surface of the bacteria (Berlutti et al, 2010;Wakabayashi et al, 2010;Latorre, Berlutti, Valenti, Gessani, Puddu, 2012), and (3) inhibiting the growth of biofilm (Chen, Wen, 2011).…”

Section: The Antimicrobial Properties Of Lactoferrinmentioning

confidence: 99%

“…A new method of treating periodontal disease uses bovine LF (1) inhibiting the inflammatory process by binding free iron ions, (2) binding to the surface of the bacteria (Berlutti et al, 2010;Wakabayashi et al, 2010;Latorre, Berlutti, Valenti, Gessani, Puddu, 2012), and (3) inhibiting the growth of biofilm (Chen, Wen, 2011).…”

Section: The Antimicrobial Properties Of Lactoferrinmentioning

confidence: 99%

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Injuries in Thai Boxing

Sieńko-Awierianów

Orłowski²,

Chudecka

2016

Central European Journal of Sport Sciences and Medicine

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Lactoferrin (LF) is an iron-binding glycoprotein from the transferrin family, which has been identified in most biological fluids as secretions from exocrine glands and the content of specific granules of neutrophils. It has been reported to have numerous functions. Due to antimicrobial and anti-inflammatory activity, the lactoferrin plays significant role in host defense against infection and extreme inflammation. Recent studies have also demonstrated that LF can protect against cancer in experimental animals and has anticarcinogenic activity in many human tumors. At the cellular level, LF modulates the proliferation, differentiation, maturation, activation, migration and function of immune cells. This review presents the multifunctional roles and specific beneficial properties of lactoferrin.

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Section: The Antimicrobial Properties Of Lactoferrinmentioning

confidence: 99%

Section: The Antimicrobial Properties Of Lactoferrinmentioning

confidence: 99%

Injuries in Thai Boxing

Sieńko-Awierianów

Orłowski²,

Chudecka

2016

Central European Journal of Sport Sciences and Medicine

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“…Similarly, continuously acute inflammation in periodontal pockets and chronic inflammation in junctional epithelium and periodontal membranes are observed in patients with periodontitis. The gram-negative bacteroides such as Porphyromonas gingivalis, Tannerella forsythia and Aggregatibacter actinomycetemcomitans have long been studied as a potential cause of periodontitis [54,55]. Bacteroides are commonly found not only in periodontal pockets but also in the junctional epithelium where they directly digest fibroblasts of the junctional epithelium and the periodontal membranes by an enzymatic function of collagenases.…”

Section: The C5ar In Periodontitismentioning

confidence: 99%

New aspects of the C5a receptor

Nishiura¹,

Ohura²

2014

ABB

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The process of apoptotic cell death for maintenance of cell homeostasis is now believed to be flexible. To examine the mechanism for this flexibility, the process of programmed cell death is sometimes divided into three phases: initiation, effector and execution. We have demonstrated that apoptotic cells commonly express a de novo synthesized C5a receptor (C5aR), which belongs to the G protein-coupled receptor (GPCR) family. A natural agnostic ligand of the C5aR, C5a, is produced from plasma C5 by C5 convertase in the early phase of acute inflammation. Although it is not realistic, we found that C5a can adjust apoptotic cell lifespan long. We recently have read interesting reports that apoptotic cells can release natural agnostic ligands at the initiation phase and corresponding GPCRs are already expressed on cell surfaces of apoptotic cells. Conversely, we found that apoptotic cells commonly release an alternative antagonistic/agnostic ligand of the de novo synthesized C5aR, ribosomal protein S19 (RP S19) polymer. The RP S19 polymer can adjust apoptotic cell lifespan short. Importantly, the C5a-dependent regulation is limited by the C5aR sensitization, but the RP S19 polymer-dependent regulation is unlimited by the C5aR desensitization. Therefore, we suggested that apoptotic cells commonly release agnostic ligands in the initiation phase that should lengthen intermittently a period of the initiation phase. Next, apoptotic cells commonly release antagonistic/agnostic ligands in the effector phase that should continue shortening a period of the effector phase. In addition, we know that an inherited erythroblastopenia is associated with mutations in the RP S19 gene. However, the roles of RP S19 in the formation of erythroblast-macrophage islands are not clearly understood. We recently have found that a different arm that the RP S19 polymer has connects the de novo synthesized C5aR on erythroblasts and the generally expressed C5aR on macrophages. Therefore, we suggested that apoptotic cells commonly release antagonistic/agnostic ligands in the execution phase that should continue connecting apoptotic cells and macrophages in the execution phase for shortening a period of the execution phase. In this review, we introduce new aspects of the C5aR in apoptotic cells and discuss the effects of the long lifespan of apoptotic cell-like neutrophils on the development of periodontitis.

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“…Meanwhile, phosphomycin is able to destroy the bacterial cell surface proteins and also prevents the interaction between bacterial cell fimbriae proteins and extra cellular cell matrix proteins. 32 The advantage of phosphomycin is that it disrupts cytoplasmic activity in peptidoglycan biosynthesis as well as inhibits the synthesis of the MurA enzyme that attaches to host cells. 33 Therefore, phosphomycin may act as a potent anti-biofilm to the micro plate since they are …”

mentioning

confidence: 99%