Periodontitis is associated with the development of fungal sinusitis: A nationwide 12‐year follow‐up study

Abstract

Aim The incidence of fungal sinusitis is increasing; however, its pathophysiology has not been investigated previously. We investigate the effect of periodontitis on the incidence of fungal sinusitis over a 12‐year follow‐up period using nationwide population‐based data. Materials and Methods The periodontitis group was randomly selected from the National Health Insurance Service database. The non‐periodontitis group was obtained by propensity score matching considering several variables. The primary end point was the diagnosis of sinonasal fungal balls (SFBs) and invasive fungal sinusitis (IFS). Results The periodontitis and non‐periodontitis groups included 12,442 and 12,442 individuals, respectively. The overall adjusted hazard ratio (aHR) for SFBs in the periodontitis group was 1.46 (p = .002). In subgroup analysis, the aHR for SFBs was 1.59 (p = 0.008) for those with underlying chronic kidney disease (CKD), 1.58 (p = .022) for those with underlying atopic dermatitis, 1.48 (p = .019) for those with chronic obstructive pulmonary disease (COPD), and 1.36 (p = .030) for those with diabetes mellitus (DM), but these values are applicable only when considering the relationship between periodontitis and SFB. The aHR for IFS in the periodontitis group was higher than in the non‐periodontitis group (2.80; p = .004). Conclusions The risk of SFBs and IFS increased after diagnosis of periodontitis. This trend is often more severe in patients with DM, COPD, or CKD, but this association with underlying diseases is applicable only when considering the association between periodontitis and fungal sinusitis.

Long-term bidirectional association between asthma and attention deficit hyperactivity disorder: A big data cohort study

“…From the asthma cohort (defined earlier), the control group was matched by 1:1 propensity score (PS) matching considering seven covariates, including the Charlson comorbidity index (CCI). We conducted PS matching using a "greedy nearest neighbor" algorithm with a 1:1 ratio (18)(19)(20)(21)(22)(23)(24). The success of PS matching was confirmed by standardized mean differences (SMDs) in each group (Table 1) (18)(19)(20)(21)(22)(23)(24).…”

“…We conducted PS matching using a "greedy nearest neighbor" algorithm with a 1:1 ratio (18)(19)(20)(21)(22)(23)(24). The success of PS matching was confirmed by standardized mean differences (SMDs) in each group (Table 1) (18)(19)(20)(21)(22)(23)(24). The initiation point for the study group was the date of the first asthma diagnosis, and that for the control group was the date of the first visit to the hospital from January 1, 2009.…”

Association between sinusitis and incident rheumatic diseases: a population-based study

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Dental implant as a potential risk factor for maxillary sinus fungus ball

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