Long-term bidirectional association between asthma and attention deficit hyperactivity disorder: A big data cohort study

Park, Hye Jin; Kim, Young Hyeon; Na, Da Ye; Jeong, Seong Won; Lee, Min Gyu; Lee, Jong‐Hwan; Yang, Yun Su; Kang, Min‐Gu; Yeom, Sang Woo; Kim, Jong Seung

doi:10.3389/fpsyt.2022.1044742

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…In this French birth cohort EDEN, we found evidence of a longitudinal pathway from low income to ADHD symptoms, partially mediated by asthma. The positive association found between child asthma and ADHD is in line with previous research in the US, Canada, Denmark, and South Korea 5 , 6 , 12 , 28 , 40 , quantitatively summarised in systematic reviews/meta-analyses 7 , 10 , 11 , 14 , 41 . A possible explanation for this association might be that both conditions involve inflammation and immune system dysregulation.…”

Section: Discussionsupporting

confidence: 90%

Associations between symptoms of attention-deficit hyperactivity disorder, socioeconomic status and asthma in children

Omura,

Cortese,

Bailhache

et al. 2024

npj Mental Health Res

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Socioeconomic status (SES) influences the risk of both physical diseases, such as asthma, and neurodevelopmental conditions, including attention-deficit/hyperactivity disorder (ADHD). Using Causal Mediation Analysis on French birth-cohort data, we found a causal pathway from SES to ADHD symptoms, in part mediated by asthma. An increase in family income at age 3 by one unit resulted in lower ADHD symptoms at age 5, by −0.37 [95% CI: −0.50, −0.24] SDQ-score-points, with additional −0.04 [95% CI: −0.08, −0.01] points reduction indirectly via asthma at age 3, both with statistical significance. Importantly, family income at age 3 exerted both direct and indirect (via asthma) negative effects on later ADHD symptoms with much higher magnitudes for the direct effect. Our findings underscore the importance of apprehending ADHD symptoms in the broader context of socioeconomic disparities, along with their comorbidities with asthma, potentially influencing public health interventions and clinical practice in managing ADHD.

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Section: Discussionsupporting

confidence: 90%

Associations between symptoms of attention-deficit hyperactivity disorder, socioeconomic status and asthma in children

Omura,

Cortese,

Bailhache

et al. 2024

npj Mental Health Res

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“…By means of a comparison, a recent investigation in children suggested that incidence of attention deficit hyperactivity disorder (ADHD) was 1.17 times higher in the asthma group than in the non-asthma group. 32 Other studies had similar results and elaborated that symptoms of ADHD could negatively affect the course of asthma treatment, 33 which could lead to an increase in asthma morbidity. In some instances, parents with a low socioeconomic background were also diagnosed with attention deficit problems, which affected the management of their child's asthma and ADHD.…”

Section: Multivariable Analysesmentioning

confidence: 85%

Are the presence of asthma and the COVID-19 infection associated with behavioral changes in Lebanese adolescents?

Azzi,

Karam,

D’Andrea

et al. 2023

Allergol Immunopathol

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Background: Little evidence is available about psychological stressors in Lebanese asthmatic adolescents, where health-risk behaviors are a serious threat to public health. In addition, the COVID-19 epidemic has had a substantial influence on adolescents’ mental health globally, especially in Lebanon, where the ongoing economic and political challenges have largely impacted their psychological well-being. This study aimed to explore the association of asthma and the COVID-19 infection with behaviors among Lebanese adolescents. Methods: Data were collected in July 2023, using the snowball sampling technique. Inclusion criteria for participation in the study included being of a resident and citizen of Lebanon and aged 12–18 years. Behavioral problems were assessed using the Youth Self-Report (YSR) scale, which yields nine subscales (anxious/depressed, withdrawn/depressed, somatic complaints, social problems, thought problems, attention problems, rule-breaking behavior, aggressive behavior, and other problems) and a total score. Results: Asthma was significantly associated with somatic complaints (Beta [β] = 2.98), attention problems (β = 0.01), and other behavioral problems (β = 0.68). Having contracted the COVID-19 infection, compared to healthy asymptomatic state (β = 1.55), was significantly associated with more anxious behaviors. In the case of stratifying the analysis in terms of gender, the results showed that the presence of asthma was significantly associated with more social behaviors (β = 3.31), thought problems (β = 2.91), attention problems (β = 0.02), other behavioral problems (β = 1.71), and total behavioral problems (β = 5.71) in males. In case stratifying the analysis as to school type, the presence of asthma was significantly associated with more somatic complaints (β = 2.77) in participants from private schools whereas it was significantly associated with more total behavioral problems (total YSR scores) (β = 5.05) in participants from public schools. Conclusion: It is confirmed that asthma and psychiatric disorders are interconnected, so it would be of great importance to include screening through a psychological intervention in treating asthmatic adolescents by means of (1) recognizing factors affecting patients’ mental health, and (2) regulating uncontrolled behaviors that can exacerbate symptoms in order to avoid the future morbidity.

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“…A study on a large and representative population[ 20 ] showed that parental use of asthma and allergic rhinitis medications increased the risk of offspring needing to use ADHD medication. Furthermore, studies have shown[ 21 ] that adverse maternal factors during pregnancy, including negative emotional states and exposure to toxic substances, can influence the development of comorbid asthma in children with ADHD. Maternal exposure to toxic substances during pregnancy can affect the normal growth and development of the fetus, especially central nervous system development, leading to abnormalities in brain function and an increased likelihood of ADHD in children.…”

Section: Discussionmentioning

confidence: 99%

Clarifying the relationship and analyzing the influential factors of bronchial asthma in children with attention-deficit hyperactivity disorder

Wang,

Xu,

2024

World J Psychiatry

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BACKGROUND Bronchial asthma is closely related to the occurrence of attention-deficit hyperactivity disorder (ADHD) in children, which can easily have adverse effects on children’s learning and social interactions. Studies have shown that childhood asthma can increase the risk of ADHD and the core symptoms of ADHD. Compared with children with ADHD alone, children with asthma and ADHD are more likely to show high levels of hyperactivity, hyperactive-impulsive and other externalizing behaviors and anxiety in clinical practice and have more symptoms of somatization and emotional internalization. AIM To explore the relationship between ADHD in children and bronchial asthma and to analyze its influencing factors. METHODS This retrospective cohort study was conducted at Dongying People's Hospital from September 2018 to August 2023. Children diagnosed with ADHD at this hospital were selected as the ADHD group, while healthy children without ADHD who underwent physical examinations during the same period served as the control group. Clinical and parental data were collected for all participating children, and multivariate logistic regression analysis was employed to identify risk factors for comorbid asthma in children with ADHD. RESULTS Significant differences were detected between the ADHD group and the control group in terms of family history of asthma and allergic diseases, maternal complications during pregnancy, maternal use of asthma and allergy medications during pregnancy, maternal anxiety and depression during pregnancy, and parental relationship status (P < 0.05). Out of the 183 children in the ADHD group, 25 had comorbid asthma, resulting in a comorbidity rate of 13.66% (25/183), compared to the comorbidity rate of 2.91% (16/549) among the 549 children in the control group. The difference in the asthma comorbidity rate between the two groups was statistically significant (P < 0.05). The results of the multivariate logistic regression analysis indicated that family history of asthma and allergic diseases, maternal complications during pregnancy, maternal use of asthma and allergy medications during pregnancy, maternal anxiety and depression during pregnancy, and parental relationship status are independent risk factors increasing the risk of comorbid asthma in children with ADHD (P < 0.05). CONCLUSION Children with ADHD were more likely to have comorbid asthma than healthy control children were. A family history of asthma, adverse maternal factors during pregnancy, and parental relationship status were identified as risk factors influencing the comorbidity of asthma in children with ADHD. Clinically, targeted interventions based on these factors can be implemented to reduce the risk of comorbid asthma. This information is relevant for results sections of abstracts in scientific articles.

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Long-term bidirectional association between asthma and attention deficit hyperactivity disorder: A big data cohort study

Cited by 3 publications

References 29 publications

Associations between symptoms of attention-deficit hyperactivity disorder, socioeconomic status and asthma in children

Associations between symptoms of attention-deficit hyperactivity disorder, socioeconomic status and asthma in children

Are the presence of asthma and the COVID-19 infection associated with behavioral changes in Lebanese adolescents?

Clarifying the relationship and analyzing the influential factors of bronchial asthma in children with attention-deficit hyperactivity disorder

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