Periodontitis is associated to increased systemic inflammation in postmyocardial infarction patients

Abstract

ObjectivePeriodontitis has been independently associated to cardiovascular disease. However, the biological mechanisms underlying such association are still partially unknown. Thus, this study aimed to discover immunological clues accounting for the increased risk of myocardial infarction (MI) in patients having periodontitis.MethodsWe included 100 patients with a first MI, 50 with and 50 without severe periodontitis, and 100 age-matched, sex-matched and area-matched controls from the Periodontitis and Its Relation to Coronary Artery Disease Study. Participants underwent comprehensive clinical and laboratory examinations 6–10 weeks after the MI and plasma expression of 92 inflammation-related markers was assessed through proximity extension assay.ResultsPatients who had an MI displayed altered expression of CCL19, TNFRSF9 and LAP TGF-β1 in comparison with controls. TNFRSF9 correlated significantly with the amount of alveolar bone loss. MI patients with deep periodontal pockets showed increased white cell count and higher expression of FGF-21, HGF, OSM, CCL20 and IL-18R1 than patients without. White cell count correlated significantly with four of these proteins.ConclusionsCollectively, our results indicate molecular markers that could be responsible for the increased systemic inflammatory activity in patients with MI with periodontitis.

Cerebral Small Vessel Disease – A Longitudinal 10 Years Evidenced Study

“…Cognitive decline and dementia were proven with cerebrovascular pathology on MRI findings to be associated with symptomatic stroke including silent stroke and markers of cerebral small vessel diseases especially among subjects with atrial fibrillation as evidence in a birth cohort researched by Lira ryden et al [39]. However this research subjects did not have any known atrial fibrillation.…”

Prediction of Interactomic HUB Genes in Periodontitis With Acute Myocardial Infarction

“…In contrast, patients who have already experienced an increased risk of complications and worsen the prognosis. 2,[35][36][37] GWASs have been widely used to find genetic variations that might be connected to PD and CAD/MI. In GWASs of CAD, more than 50 loci have been discovered.…”

“…TAB2 is necessary to prevent aberrant cardiac remodeling and heart failure. 2,37 Predicting hub genes using machine learning typically involves a combination of gene expression data analysis, feature selection, and the application of machine learning algorithms. Thus, predicting and identifying hub genes is crucial for the long-term monitoring and diagnosis of AMI and Periodontitis.…”

“…A cute myocardial infarction (AMI) is one of the dominating mainspring of death in the globe due to cardiovascular diseases (CVDs). 1,2 Atherosclerosis, which shares risk factors with periodontitis, is the underlying etiology of both disorders. Systemic inflammation caused by periodontitis can culminate in atherosclerosis and endothelial dysfunction.…”

“…Systemic inflammation caused by periodontitis can culminate in atherosclerosis and endothelial dysfunction. For the past 50 years, numerous investigations have shown a link between periodontitis and CVD in the form of AMI 2–4 . A strong noncausal relationship between periodontitis and CVD was discovered in 2013 by the European Federation of Periodontology and the American Academy of Periodontology.…”