Periodontitis as an Independent Factor in Pathogenesis of Erectile Dysfunction

Kulshrestha, Reena; Chaudhuri, Gargi Ray; Bhattacharya, Koushik; Dutta, Sulagna; Sengupta, Pallav

doi:10.13005/bpj/1852

Cited by 10 publications

(5 citation statements)

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“…PD and ED share risk factors such as age, obesity, smoking, diabetes mellitus, metabolic syndrome, hypertension, cardiovascular diseases, and excessive drinking (Machado et al, 2020; Zuo et al, 2011). Both, also share common pathophysiological pathways, including endothelial dysfunction and inflammation (Kulshrestha et al, 2020). The evidence is strengthened by the findings that smoking cessation, reduction of obesity, and avoiding other common risk factors are safe and effective means to reduce the incidence of both diseases.…”

Section: Discussionmentioning

confidence: 99%

“…It has been confirmed in experimental and clinical studies that PD could impair vascular endothelial dysfunction (Amar et al, 2003; Blum et al, 2007) by increasing the expression of proinflammatory cytokines and adhesion molecules. In addition, PD induce a mild systematic inflammatory status and decrease the activity of endothelial nitric oxide synthase and nitric oxide synthase in penile cavernous tissues of rats (Kulshrestha et al, 2020; Pedrotti et al; Zuo et al, 2011). Periodontal therapy may improve damaged vascular endothelial function and results in significant improvement in the function (Gurav, 2014; Scannapieco et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

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The Association Between Periodontitis and Erectile Dysfunction: A Systematic Review and Meta-Analysis

et al. 2021

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The objective of this study is to investigate the association between periodontitis (PD) and erectile dysfunction (ED). A systematic review and meta-analysis on data was extracted and conducted according to PRISMA. Relevant articles were selected from a literature search using MEDLINE, EMBASE, Scopus, Web of Science and CENTRAL from inception until August 2, 2020. Both randomized and nonrandomized controlled studies were included. Case reports, case series, nonsystematic reviews and trials published as abstract were excluded. Odds ratios (ORs) and corresponding 95% conﬁdence intervals (CIs) were used to estimate the association between PD and the risk of ED. The meta-analysis was conducted with RevMan 5.3. Methodological quality assessment was carried out using the Newcastle-Ottawa Quality Assessment Scale and the quality of evidence was assessed using the GRADE approach. Six articles (215008 subjects) were included for analysis. Of the participants, 38,675 cases were compared to 1,76,333 healthy controls. Based on the random effects model, periodontitis was associated with an increased risk of ED (OR = 2.56, 95% CI: 1.70–3.85) as compared with the non-periodontitis individuals. The findings were statistically significant with a p < .0001. The statistical heterogeneity was high across all studies ( I2 = 98%, p < .00001). Estimates of total effects were generally consistent with the sensitivity and subgroup analyses. Within the limits of the available evidence, our review and meta-analysis showed that a significant association exists between the PD and ED. The results should be interpreted with caution due to high degree of inconsistency across all the studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Association Between Periodontitis and Erectile Dysfunction: A Systematic Review and Meta-Analysis

et al. 2021

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“…Thus, for the sufficient erection, both NOS and NO both necessary, and for NOS activity, NANC must be active. However, a recent study reported weak cholinergic response and altered autonomic activity in obese rat with peripheral insulin resistance [174,175]. Importantly, male infertility due to ED shows a positive correlation with increased BMI and waist circumference [176].…”

Section: Obesity and Erectile Dysfunctionmentioning

confidence: 96%

Obesity and male infertility: multifaceted reproductive disruption

Chaudhuri

Das

Kesh

et al. 2022

Middle East Fertil Soc J

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Background The global prevalence of obesity has soared to a concerning height in the past few decades. Interestingly, the global decline in semen quality is a parallel occurrence that urges researchers to evaluate if obesity is among the most essential causatives of male infertility or subfertility. Main body Obesity may alter the synchronized working of the reproductive-endocrine milieu, mainly the hypothalamic-pituitary-gonadal (HPG) axis along with its crosstalks with other reproductive hormones. Obesity-mediated impairment in semen parameters may include several intermediate factors, which include physical factors, essentially increased scrotal temperature due to heavy adipose tissue deposits, and systemic inflammation and oxidative stress (OS) initiated by various adipose tissue-derived pro-inflammatory mediators. Obesity, via its multifaceted mechanisms, may modulate sperm genetic and epigenetic conformation, which severely disrupt sperm functions. Paternal obesity reportedly has significant adverse effects upon the outcome of assisted reproductive techniques (ARTs) and the overall health of offspring. Given the complexity of the underlying mechanisms and rapid emergence of new evidence-based hypotheses, the concept of obesity-mediated male infertility needs timely updates and pristine understanding. Conclusions The present review comprehensively explains the possible obesity-mediated mechanisms, especially via physical factors, OS induction, endocrine modulation, immune alterations, and genetic and epigenetic changes, which may culminate in perturbed spermatogenesis, disrupted sperm DNA integrity, compromised sperm functions, and diminished semen quality, leading to impaired male reproductive functions.

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“…Endothelial dysfunction and injury caused by proinflammatory mediators of chronic periodontitis such as tumor necrosis factor-α (TNF-α), interleukin (IL)-1, and IL-6 could also affect the vasculogenic pathway resulting in erectile dysfunction [66][67][68][69]. These proposed mechanisms are still being investigated.…”

Section: Periodontal Reproductive and Sexual Health And Concurrent Am...mentioning

confidence: 99%

aMMP-8 Oral Fluid PoC Test in Relation to Oral and Systemic Diseases

Sorsa

Nwhator

Sakellari

et al. 2022

Front. Oral. Health

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The manuscript uses the previously published literature and highlights the benefits of active-matrix metalloproteinase (aMMP)-8 chairside/point-of-care (PoC) diagnostic tools as adjunctive measures in oral and systemic diseases. Previous studies suggest that as a biomarker, aMMP-8 is more precise than total MMP-8, MMP-9, MMP-2, MMP-3, MMP-13, MMP-7, MMP-1, calprotectin, myeloperoxidase (MPO), human neutrophil elastase (HNE), tissue inhibitor of matrix metalloproteinase (TIMP)-1, and bleeding of probing (BOP). Therefore, aMMP-8 could be implemented as the needed key biomarker for the new disease classification for both periodontitis and peri-implantitis. With a sensitivity to the tune of 75–85% and specificity in the range of 80–90%, lateral flow aMMP-8 PoC testing is comparable to catalytic protease activity assays for aMMP-8. The test can be further applied to estimate the glycemic status of an individual, to ascertain whether a person is at risk for COVID-19, in managing the oral side effects of radiotherapy carried in head and neck cancers, and in selected cases pertaining to reproductive health. In the future, aMMP-8 could find application as a potential systemic biomarker in diseases affecting the cardiovascular system, cancers, bacteremia, sepsis, diabetes, obesity, meningitis, as well as pancreatitis. The aMMP-8 PoCT is the first practical test in the emerging new dental clinical field, that is, oral clinical chemistry representing oral medicine, clinical chemistry, peri-implantology, and periodontology.

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Periodontitis as an Independent Factor in Pathogenesis of Erectile Dysfunction

Cited by 10 publications

References 0 publications

The Association Between Periodontitis and Erectile Dysfunction: A Systematic Review and Meta-Analysis

The Association Between Periodontitis and Erectile Dysfunction: A Systematic Review and Meta-Analysis

Obesity and male infertility: multifaceted reproductive disruption

aMMP-8 Oral Fluid PoC Test in Relation to Oral and Systemic Diseases

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