Periodontitis and risk of psoriasis: a systematic review and meta‐analysis

Abstract

Background The association between periodontitis and systemic diseases has been increasingly recognized. However, the data on the association between periodontitis and psoriasis are still limited. Objectives To summarize all available data on the association between periodontitis and the risk of psoriasis. Methods Two investigators independently searched published studies indexed in MEDLINE and EMBASE databases from inception to July 2016 using a search strategy that included terms for psoriasis and periodontitis. Studies were included if the following criteria were met: (1) Case-control or cohort study comparing the risk of psoriasis in subjects with and without periodontitis ;(2) subjects without periodontitis were used as comparators in cohort studies while participants without psoriasis were used as controls in case-control studies; and (3) effect estimates and 95% confidence intervals (CI) were provided. Point estimates and standard errors from each study were extracted and combined together using the generic inverse variance technique described by DerSimonian and Laird. Results Two cohort studies and three case-control studies met the inclusion criteria and were included in the meta-analysis. The pooled risk ratio of psoriasis in patients with periodontitis versus comparators was 1.55 (95% CI, 1.35–1.77). The statistical heterogeneity was insignificant with an I2 of 18%. Subgroup analysis according to study design revealed a significantly higher risk among patients with periodontitis with a pooled RR of 1.50 (95% CI, 1.37 – 1.64) for cohort studies and a pooled RR of 2.33 (95% CI, 1.51 – 3.60) for case-control studies. Conclusions Patients with periodontitis have a significantly elevated risk of psoriasis.

Periodontitis as another comorbidity associated with psoriasis: A case‐control study

“…In a recent systematic review and meta analyses, Ungprasert et al . provided careful analysis of two case‐control studies and three cohort studies and revealed that individuals presenting periodontitis showed significantly higher risk (pooled RR = 1.55, 95%CI 1.35–1.77; p < 0.001) of psoriasis.…”

The Prevalence of Periodontitis Is Increased in Psoriasis and Linked to Its Inverse Subtype

“…Keller and Lin [14] reported from a large-scale population-based study in Taiwan that the incidence rate of psoriasis per 1,000 person-years during a 5-year follow-up period was 1.88 in patients with periodontitis compared to 1.22 in comparator patients (without periodontitis). Finally, a recent review reports a pooled risk ratio of psoriasis patients with periodontitis versus comparators of 1.55 [15]. Whether the strong link between the inverse type of psoriasis [16] and periodontitis is due to a causal relationship needs to be determined.…”

Assoziation zwischen Psoriasis und Parodontitis bei der dermatologischen Untersuchung nicht vergessen

“…der chronisch spontanen Urtikaria (csU) und Psoriasis, wird/wurde traditionell eine Fokussuche durchgeführt, die vorrangig Ausschluss, gegebenenfalls Behandlung eines entzündlichen Geschehens im Hals-Nasen-Ohren-Bereich und im Zahn-Mund-Kiefer-Bereich beinhaltet. Während lange Zeit diese Maßnahmen bona fide ohne robuste wissenschaftliche Grundlage durchgeführt wurden, belegen nun zahlreiche kürzlich erschienene Arbeiten [1,2,3,4,5] eine erhöhte Inzidenz von Parodontitis bei Patienten mit Psoriasis gegenüber der Normalbevölkerung und legen eine ähnliche Entzündungskaskade bei beiden Krankheitsbildern nahe.…”