Periodontitis as another comorbidity associated with psoriasis: A case‐control study

Mendes, Victor Silva; Cota, Luís Otávio Miranda; Costa, Amanda Almeida; Oliveira, Alcione Maria Soares Dutra; Costa, Fernando Oliveira

doi:10.1002/jper.18-0394

Cited by 27 publications

(68 citation statements)

References 47 publications

(141 reference statements)

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“…Next, 215 records that were irrelevant to our topic were excluded after the titles and abstracts were screened, leaving 23 articles for a further full text review. Finally, 8 studies fulfilled the eligibility criteria and were included in this meta-analysis (20, 22–28). The flow chart of the study selection process is displayed in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

Psoriasis Patients Suffer From Worse Periodontal Status—A Meta-Analysis

et al. 2019

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Background and Objective: Patients with psoriasis have a significantly elevated risk of periodontitis compared with the nonpsoriasis controls. However, the data regarding the difference in the periodontal health status of the psoriasis patients and the nonpsoriasis controls are limited and inconsistent; hence, a specialized meta-analysis that quantitatively compared the periodontal status between the psoriasis and nonpsoriasis subjects by evaluating the related clinical periodontal indexes was needed. The aim of this meta-analysis was to quantitatively evaluate whether the periodontal status of psoriasis patients is worse than that of nonpsoriasis subjects.Methods: We searched PubMed and EMBASE for all eligible studies that compared the periodontal status between psoriasis patients and nonpsoriasis subjects. The studies were screened based on pre-established inclusion criteria. After extracting the available periodontal indexes from the included studies, the weighted mean difference (WMD) with 95% confidence intervals (CIs) was calculated by pooling the mean and standard deviations (SD) of each index.Results: In total, 8 studies, including 812 psoriasis patients and 772 nonpsoriasis subjects, were included in our meta-analysis, and the publication dates ranged from 2013 to 2019; eight periodontal indexes were analyzed. The WMD (95% CIs) for each index were: bleeding on probing (%), 9.188 (4.046–14.330, P < 0.001); probing depth (mm), 0.524 (0.183–0.865, P = 0.003); clinical attachment loss (mm), 0.408 (0.051–0.765, P = 0.025); plaque index, 0.186 (−0.170 to 0.543, P = 0.306); gingival index, 0.458 (−0.413 to 1.328, P = 0.303), remaining teeth, −1.709 (−2.106 to −1.312, P < 0.001); missing teeth, 1.130 (0.275–1.985, P = 0.010); the level of alveolar bone loss (mm), 0.400 (0.102–0.698, P = 0.008).Conclusion: In summary, our meta-analysis revealed that psoriasis patients suffer from worse periodontal health than do nonpsoriasis subjects, mainly characterized by worse gingival inflammation, more alveolar bone loss, fewer remaining teeth and more missing teeth. Considering the limitations of this meta-analysis, more high-quality and well-designed studies are needed to validate our conclusions in the future.

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Section: Resultsmentioning

confidence: 99%

Psoriasis Patients Suffer From Worse Periodontal Status—A Meta-Analysis

et al. 2019

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“…Many retrospective and case-control studies have reported an association between psoriatic diseases, mainly psoriasis vulgaris and psoriatic arthritis, and periodontal disease [95,96,97]. A large 5-year follow-up cohort study indicated that in psoriasis patients (psoriasis subtypes not specified), chronic periodontitis showed an incidence rate of 1.88 per 1000 patient-years compared to 1.22 in the control group [98].…”

Section: Th17/il-17 In Immunoprotection and Immunopathologymentioning

confidence: 99%

Th17 Cells and the IL-23/IL-17 Axis in the Pathogenesis of Periodontitis and Immune-Mediated Inflammatory Diseases

Bunte

Beikler

2019

IJMS

341

290

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Innate immunity represents the semi-specific first line of defense and provides the initial host response to tissue injury, trauma, and pathogens. Innate immunity activates the adaptive immunity, and both act highly regulated together to establish and maintain tissue homeostasis. Any dysregulation of this interaction can result in chronic inflammation and autoimmunity and is thought to be a major underlying cause in the initiation and progression of highly prevalent immune-mediated inflammatory diseases (IMIDs) such as psoriasis, rheumatoid arthritis, inflammatory bowel diseases among others, and periodontitis. Th1 and Th2 cells of the adaptive immune system are the major players in the pathogenesis of IMIDs. In addition, Th17 cells, their key cytokine IL-17, and IL-23 seem to play pivotal roles. This review aims to provide an overview of the current knowledge about the differentiation of Th17 cells and the role of the IL-17/IL-23 axis in the pathogenesis of IMIDs. Moreover, it aims to review the association of these IMIDs with periodontitis and briefly discusses the therapeutic potential of agents that modulate the IL-17/IL-23 axis.

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“…Periodontitis is an infectious inflammatory condition that causes destruction of dental supporting structures (Kinane & Bartold, ). Considering its complex pathogenesis, the susceptibility to periodontitis is related to disorders of the polymicrobial synergism that results in dysbiosis (Mendes, Cota, Costa, Oliveira, & Costa, ; Shaikh, Patil, Pangam, & Rathod, ).…”

Section: Introductionmentioning

confidence: 99%

“…Considering its complex pathogenesis, the susceptibility to periodontitis is related to disorders of the polymicrobial synergism that results in dysbiosis (Mendes, Cota, Costa, Oliveira, & Costa, 2019;Shaikh, Patil, Pangam, & Rathod, 2018).…”

Section: Introductionmentioning

confidence: 99%

Periodontitis in individuals with liver cirrhosis: A case–control study

Costa

Lages

et al. 2019

J Clinic Periodontology

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Aim The aim of this study was to evaluate the association between liver cirrhosis and periodontitis. Methods This case–control study included 294 individuals, 98 cases with liver cirrhosis and 196 controls. A full‐mouth periodontal examination was performed and plaque index, probing depth, clinical attachment level and bleeding on probing were recorded. The association of risk variables with periodontitis was tested through univariate analysis and multivariate logistic regression, stratified by alcohol status. Results A high prevalence of periodontitis was observed among cases (62.2%) when compared to controls (41.8%). Individuals with cirrhosis presented a chance ~2 higher of having periodontitis than controls (OR = 2.28; 95% CI 1.39–3.78; p < .001). Significant variables associated with periodontitis in the final logistic models were as follows: (a) no/occasional alcohol use model—number of teeth up 14, age ≥45–55 years, male sex and smoking; (b) moderate and intensive alcohol use models—cirrhosis, number of teeth up 14, age ≥45–55 years, male sex and smoking. Conclusions An important risk association between liver cirrhosis and periodontitis was observed. Additionally, the intensive alcohol use significantly increased the risk for periodontitis.

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Periodontitis as another comorbidity associated with psoriasis: A case‐control study

Cited by 27 publications

References 47 publications

Psoriasis Patients Suffer From Worse Periodontal Status—A Meta-Analysis

Psoriasis Patients Suffer From Worse Periodontal Status—A Meta-Analysis

Th17 Cells and the IL-23/IL-17 Axis in the Pathogenesis of Periodontitis and Immune-Mediated Inflammatory Diseases

Periodontitis in individuals with liver cirrhosis: A case–control study

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