Periodontitis and implant complications in diabetes

Nibali, Luigi; Gkranias, Nikolaos; Mainas, Giuseppe; Pino, Antonino Di

doi:10.1111/prd.12451

Cited by 46 publications

(27 citation statements)

References 252 publications

(534 reference statements)

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“…Epidemiologic evidence indicates that periodontitis is more frequent in patients with uncontrolled diabetes mellitus than in healthy controls, suggesting that it could be considered the “sixth complication” of diabetes. 7 Diabetes mellitus and periodontitis are two extraordinarily prevalent chronic diseases that share a number of comorbidities, all converging towards an increased risk of cardiovascular disease. Periodontal treatment has recently been shown to have the potential to improve the metabolic control of diabetes, although long‐term studies are lacking.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for periodontitis & peri‐implantitis

Darby

2022

Periodontology 2000

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Risk is part of all health professions and generally indicates the chance of getting some form of illness. For dental practitioners this includes periodontitis or peri‐implantitis, the focus of this issue. Many risk factors are involved in the development of disease and most likely interact or overlap. Most patients will probably have multiple risk factors, some of which will be the same for both periodontitis and peri‐implantitis. The most recent classification of periodontal disease recognises the importance of risk factors and contemporary dental practice requires that clinicians be aware of and manage them. Broadly speaking risk factors can be patient, environment or practitioner related. Patient risk factors would include socio‐economic status, smoking, substance use disorders, diabetes, diet and dietary supplements, mental health disorders, old age, poor home dental care or understanding of the need for good home care and use of medications. Environmental modification of the host response through gene function is an emerging risk factor. Lastly, practitioner‐related factors in implant dentistry are now known to affect risk. These would include the use of digital technology, but patient related factors such implant location and the body’s reaction to an implant itself add to the risk of developing disease. This edition of Periodontology provides an uptodate review of many of these risk factors and their impact summarising current knowledge.

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Section: Introductionmentioning

confidence: 99%

Risk factors for periodontitis & peri‐implantitis

Darby

2022

Periodontology 2000

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“…The spectrum of the detrimental macrophage reactions will depend on the implant characteristics as well as the status of the immune system (both local and systemic) of the patient. For example, implant integration in diabetic patients is significantly compromised by pro-inflammatory programming of innate immunity by metabolic factors (hyperglycemia, dyslipidemia) [ 131 , 132 , 133 , 134 , 135 ].…”

Section: Immune Response To Bioceramic Implantsmentioning

confidence: 99%

Interaction of Ceramic Implant Materials with Immune System

Rafikova

Piatnitskaia

Shapovalova

et al. 2023

IJMS

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The immuno-compatibility of implant materials is a key issue for both initial and long-term implant integration. Ceramic implants have several advantages that make them highly promising for long-term medical solutions. These beneficial characteristics include such things as the material availability, possibility to manufacture various shapes and surface structures, osteo-inductivity and osteo-conductivity, low level of corrosion and general biocompatibility. The immuno-compatibility of an implant essentially depends on the interaction with local resident immune cells and, first of all, macrophages. However, in the case of ceramics, these interactions are insufficiently understood and require intensive experimental examinations. Our review summarizes the state of the art in variants of ceramic implants: mechanical properties, different chemical modifications of the basic material, surface structures and modifications, implant shapes and porosity. We collected the available information about the interaction of ceramics with the immune system and highlighted the studies that reported ceramic-specific local or systemic effects on the immune system. We disclosed the gaps in knowledge and outlined the perspectives for the identification to ceramic-specific interactions with the immune system using advanced quantitative technologies. We discussed the approaches for ceramic implant modification and pointed out the need for data integration using mathematic modelling of the multiple ceramic implant characteristics and their contribution for long-term implant bio- and immuno-compatibility.

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“…The long-term hyperglycemia of diabetes mellitus very commonly leads to failure, damage, and/or dysfunction of many tissues and organs of the human body, causing substantial clinical morbidity [5]. A recent article reviewed the possible associations between diabetes and periodontitis, listing evidence suggesting that when uncontrolled, diabetes seems to affect response to periodontal treatment, as well as the risk to develop peri-implant diseases [6]. Although previous research did not show a clear difference in implant failure rates between diabetic and non-diabetic subjects [7][8][9], another recent review added fresh evidence to the field, suggesting that implants in diabetic patients had a higher failure risk in comparison to non-diabetic patients [10].…”

Section: Introductionmentioning

confidence: 99%

Marginal bone loss around dental implants: comparison between diabetic and non-diabetic patients—a retrospective clinical study

Ayele

Sharo

2023

Clin Oral Invest

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Objectives The aim of the present retrospective study was to compare the marginal bone loss (MBL) around dental implants in a group of diabetic patients in relation to a matched group of non-diabetic patients. Materials and methods The present dental record–based retrospective study included patients selected from individuals treated with dental implants at one specialist clinic in Malmö, Sweden. Patients were excluded if they had history of periodontitis and/or were treated for periodontal disease. The study group included 710 implants installed in 180 patients (mean age 60.3±13.0 years), 349 implants in 90 diabetic (21 T1DM and 69 T2DM patients), and 361 implants in 90 non-diabetic patients. Results The results suggested that jaw (greater MBL in the maxilla), diabetes (greater MBL for diabetic patients, and worse for T1DM patients), bruxism (greater MBL for bruxers), and smoking (greater MBL for smokers and former smokers) had a statistically significant influence on MBL over time. Conclusions Patients with diabetes have an estimated greater MBL over time compared to non-diabetic patients. The difference was greater in patients with diabetes type 1 compared to patients with diabetes type 2. Bruxism, smoking, and implant location (maxilla) were also associated with a higher loss of marginal bone around implants over time. Clinical relevance Awareness of the possible influence of diabetes on the long-term outcomes of dental implant treatment is important, in order to be able to minimize the possibility of a high MBL with time, which can eventually lead to the loss of the implant.

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Periodontitis and implant complications in diabetes

Cited by 46 publications

References 252 publications

Risk factors for periodontitis & peri‐implantitis

Risk factors for periodontitis & peri‐implantitis

Interaction of Ceramic Implant Materials with Immune System

Marginal bone loss around dental implants: comparison between diabetic and non-diabetic patients—a retrospective clinical study

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