Periodontitis and breast cancer: A case‐control study

Sfreddo, Camila Silveira; Maier, Juliana; David, Silvia Cardoso de; Susin, Cristiano; Moreira, Carlos Heitor Cunha

doi:10.1111/cdoe.12318

Cited by 36 publications

(51 citation statements)

References 27 publications

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“…There is no consistent conclusion concerning the relationship between periodontal disease and breast cancer. Five of the eight included studies (Arora, Weuve, Fall, Pedersen, & Mucci, ; Dizdar et al., ; Hujoel, Drangsholt, Spiekerman, & Weiss, ; Michaud et al., ; Sfreddo et al., .) detected no relationship between breast cancer and periodontitis.…”

Section: Discussionmentioning

confidence: 99%

“…Assessment methods for periodontal disease in previous large epidemiological studies were heterogeneous, most studies utilized self‐reported data by the patients or administrative data for the diagnosis of periodontal disease. Among the eight studies we included, six did not give clear diagnostic criteria (Arora, Weuve, Fall, Pedersen, & Mucci, ; Chung, Tsai, Huang, Kao, & Chen, ; Dizdar et al., ; Hujoel, Drangsholt, Spiekerman, & Weiss, ; Nwizu et al., ; Söder et al., ), and two studies give two and four diagnostic criteria, respectively (Michaud et al., ; Sfreddo et al., ). Michaud et al.…”

Section: Methodsmentioning

confidence: 99%

“…() gave both ARIC and CDC‐AAP diagnostic criteria, Sfreddo et al. () gave four diagnostic criteria: generalized severe periodontitis, CDC‐AAP, mean‐CAL in mm(log) and percentage of sites with CAL ≧5 mm (10% increments). Among them, CDC‐AAP is referred to the US Centers for Disease Control and Prevention‐American Academy of Periodontology definition and is developed for population‐based surveillance of periodontitis, which uses both clinical attachment level (CAL) and pocket depth.…”

Section: Methodsmentioning

confidence: 99%

“…China's annual breast cancer diagnosis rate is approximately half that of the European Union, similar to the number of cases in the United States (Fan et al., ). The incidence among women is on the rise, and to some extent, this is attributed to an earlier age of menstruation, later age of first pregnancy, fewer pregnancies and shorter periods of breastfeeding and menopause (Sfreddo, Maier, De David, Susin, & Moreira, ). In addition to these risk factors, alcohol consumption, lack of physical activity and obesity all pose a great threat to breast cancer (Colditz & Bohlke, ).…”

Section: Introductionmentioning

confidence: 99%

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Periodontal disease and susceptibility to breast cancer: A meta‐analysis of observational studies

Shi

Min

Sun

et al. 2018

J Clinic Periodontology

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Objective While some individual studies have suggested an association between periodontal disease and breast cancer, there has not been a formal meta‐analysis that collates the existing evidence supporting the hypothesis that periodontal disease leads to a higher risk of developing breast cancer. Accordingly, this meta‐analysis was conducted. Methods Relevant studies published until April 2018 were retrieved and were screened according to established inclusion criteria. Risk ratios (RRs) with 95% confidence intervals (CIs) were calculated to assess the association between periodontal disease and the risk of breast cancer and fixed effect models were used according to the results of the heterogeneity test. Results Eight studies, involving 168,111 individuals, were identified as having explored the association between periodontal disease and breast cancer. Summary estimates in view of adjusted data showed that periodontal disease did increase susceptibility to breast cancer (RR = 1.18, 95%CI: 1.11–1.26, I2 = 17.6%), with robust results confirmed by sensitivity analysis. Conclusion Our results provided evidence of a modest positive association between periodontal disease and breast cancer. Implementation of practical measures to prevent and treat periodontal disease is of great public health significance. Moreover, additional studies are recommended to explore this topic in more detail.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Periodontal disease and susceptibility to breast cancer: A meta‐analysis of observational studies

Shi

Min

Sun

et al. 2018

J Clinic Periodontology

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“…Indeed, ChP promotes systemic inflammation via translocation of oral bacteria, bacterial toxins, and inflammatory mediators through frequent transient bacteremia that would heighten the systemic burden and could promote cellular differentiation [4,13]. In addition, ChP has also been associated with cancers of the head and neck [14,15], pancreas [16], lung [17], and more recently breast cancer [18,19].…”

Section: Introductionmentioning

confidence: 99%

Subgingival microbial profile of women with breast cancer: a cross-sectional study

et al. 2019

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Background: Some prospective studies have observed associations between periodontal disease and breast cancer. Therefore, the aim of the present study was to investigate the composition of the subgingival biofilm of women diagnosed with breast cancer, who also presented with chronic periodontitis. Methods: All subjects underwent clinical and microbiological assessment. Subgingival biofilm samples were taken from at least three sites of 44 women who had breast cancer. The mean levels and proportions of 40 bacterial species were determined by checkerboard DNA-DNA hybridization. Spearman correlation was used to assess possible associations between the mean levels of bacterial species and clinical conditions. Results: The five species found at the highest levels were Prevotella nigrescens, Actinomyces gerencseriae, Neisseria mucosa, Porphyromonas gingivalis and Tannerella forsythia. The species detected in the lowest counts were Propionibacterium acnes, Streptococcus constellatus, Streptococcus intermedius, Eubacterium saburreum and Streptococcus anginosus. No significant association between levels and proportion of bacterial species and clinical parameters were found. Conclusion: In conclusion, the results of the present study found no direct association between the subgingival microbiota and breast cancer and an indirect pathway should be addressed in further studies. Trial registration: Retrospectively registered.

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Salivary and plasmatic levels of tumor necrosis factor‐alpha do not correlate with the clinicopathological profile in breast cancer patients

Opolski

Maito

Kawassaki

et al. 2022

Precision Medical Sciences

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Herein, we evaluated the salivary and plasmatic levels of tumor necrosis factor‐alpha (TNF‐α) in women diagnosed with breast cancer (BC; n = 20) versus women with benign breast conditions (Control; n = 29) and correlated the TNF‐α findings with BC clinicopathological parameters. TNF‐α was higher in the saliva samples from both groups than in plasma levels. BC and Control patients presented similar plasmatic and salivary values of TNF‐α. The salivary and plasmatic values of TNF‐α did not correlate with tumor features (estrogen receptor; progestogen receptor; Ki67, and HER2), indicating that its salivary content does not correlate with the parameters of disease prognosis. Therefore, TNF‐α is not helpful as a salivary marker in breast cancer patients.

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Periodontitis and breast cancer: A case‐control study

Abstract: A significant association was observed between periodontitis and breast cancer.

Cited by 36 publications

References 27 publications

Periodontal disease and susceptibility to breast cancer: A meta‐analysis of observational studies

Periodontal disease and susceptibility to breast cancer: A meta‐analysis of observational studies

Subgingival microbial profile of women with breast cancer: a cross-sectional study

Salivary and plasmatic levels of tumor necrosis factor‐alpha do not correlate with the clinicopathological profile in breast cancer patients

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