Periodontal disease and susceptibility to breast cancer: A meta‐analysis of observational studies

Shi, Tingting; Min, Min; Sun, Chenyu; Zhang, Yun; Liang, Mingming; Sun, Yehuan

doi:10.1111/jcpe.12982

Cited by 39 publications

(46 citation statements)

References 55 publications

(69 reference statements)

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“…12 Nwizu et al 13 reported that PD increases the risk of all cancers in older women, including breast, lung, bronchus, colon, and rectum cancers. Studies have suggested inflammation as a significant factor in both PD and cancer 14 ; inflammation might be induced through changes in the immune response or the dissemination of harmful bacteria. 15 There is ever-increasing evidence, suggesting that PD appears to be associated with lung cancer.…”

Section: Introductionmentioning

confidence: 99%

Relationship between periodontal disease and lung cancer: A systematic review and meta‐analysis

Wang

Yang

Zou

et al. 2020

J of Periodontal Research

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Periodontal disease (PD), as a chronic bacterial infection, might cause cardiovascular and some other systemic diseases, with recent studies reporting that it exhibits some connection with lung cancer. While studies have shown that poor oral health might increase the risk of lung cancer, the veracity of these reports is questionable. Therefore, this meta‐analysis was undertaken to investigate the association between PD and the risk of lung cancer. A search was run in PubMed, EMBASE, MEDLINE, CENTRAL, and ClinicalTrials.gov databases up to January 1, 2020. Cohort and case‐control studies investigating the correlation between PD and lung cancer were included. Eligibility assessment and data extraction were conducted independently, and a meta‐analysis was performed to synthesize the data. The association between PD, edentulism, and lung cancer was measured by the adjusted hazard ratios (HRs) or odds ratios (ORs) and their 95% confidence intervals (CIs) provided in articles. We employed appropriate effect model in terms of I2 (a fixed‐effect model for PD and a random‐effect model for edentulism) to obtain summary effect estimates. Statistical heterogeneity was investigated by chi‐square test and I2 statistics. Newcastle‐Ottawa Scale (NOS) was used to assess the quality of their method. Six cohort studies (eight references) and two case‐control studies, assessed as high‐quality, involving 167 256 participants, were included in the review. The summary estimates based on adjusted data showed an association between PD and a significant risk of lung cancer both in cohort studies (HR = 1.40, 95% CI = 1.25‐1.58; I2 = 8.7%) and case‐control studies (OR = 1.51, 95% CI = 1.16‐1.98; I2 = 36.5%). Similar features were found in the sensitivity analysis and subgroups for six cohort studies, of male only (HR = 1.36, 95% CI = 1.15‐2.60), setting the lung cancer incidence as endpoint (HR = 1.39, 95% CI = 1.24‐1.57; I2 = 23.9%), and adjusting alcohol for multifactorial HR (HR = 1.38, 95% CI = 1.21‐1.57; I2 = 39.9%). The summary HR for edentulism was 1.93 (95% CI = 1.05‐3.57; I2 = 55.3%). No obvious publication bias was detected. This systematic review and meta‐analysis demonstrated a significant association between PD and the incidence of lung cancer. Further observational studies are required by using standardized measurements to assess the periodontal status and by eliminating confounding factors, such as alcohol and diabetes, to verify such a relationship.

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Section: Introductionmentioning

confidence: 99%

Relationship between periodontal disease and lung cancer: A systematic review and meta‐analysis

Wang

Yang

Zou

et al. 2020

J of Periodontal Research

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“…Sufficiently long follow-up (e.g. 5-10 years) is necessary because most human cancers have a long subclinical period (38,39). In summary, our pooled analysis indicates that periodontitis is significantly associated with an increased risk of hematopoietic and lymphatic cancers, especially lymphatic cancers.…”

Section: Discussionmentioning

confidence: 73%

Hematopoietic and lymphatic cancers in patients with periodontitis: a systematic review and meta-analysis

Wu¹,

Li²,

Shi³

et al. 2020

Med Oral

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Background: Numerous studies have explored the correlation of periodontal disease (PD) with risk of hematopoietic and lymphatic cancers, but the findings were inconsistent. Therefore, we did a meta-analysis to ascertain the correlation of PD with risk of incident hematopoietic and lymphatic cancers. Material and Methods: The authors searched relevant studies in databases (PubMed, Web of Science, and MED-LINE). The summary relative risk (RR) along with 95% confidence interval (CI) was calculated by use of random or fixed effects models. Results: Six studies were included in qualitative synthesis. The pooled analysis revealed that PD was significantly associated with an increased risk of hematopoietic and lymphatic cancers (RR = 1.17; 95% CI = 1.07-1.27; P = 0). Stratified analysis showed the association of PD with hematopoietic and lymphatic cancers remained significant in the never smokers (RR = 1.28; 95% CI = 1.07-1.54; P = 0.007), and in the American population (RR = 1.17; 95% CI = 1.05-1.30; P = 0.003), respectively. Conclusion: Never smokers population and the American population with PD have a higher risk of developing hematopoietic and lymphatic cancers. PD might be considered as a risk factor for hematopoietic and lymphatic cancers.

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“…For example, platelet aggregation can be induced by oral bacteria such as P. gingivalis and S. sanguis or by the proinflammatory immune cytokines generated in response to them, affecting the formation of thrombi in the arteries and veins (Herzberg & Meyer, ). In addition, studies have demonstrated an association between periodontal disease and Alzheimer's disease (Kamer et al, ; Shaik et al, ; Singhrao, Harding, Poole, Kesavalu, & Crean, ; Watts, Crimmins, & Gatz, ), kidney disease (Fisher, Taylor, West, & McCarthy, ; Kshirsagar et al, ), negative pregnancy outcomes (Boggess, Beck, Murtha, Moss, & Offenbacher, ; Canakci et al, ; Jarjoura et al, ; Lopez, Smith, & Gutierrez, ; Moore et al, ; Offenbacher et al, ), and various types of cancer (Fitzpatrick & Katz, ; Javed & Warnakulasuriya, ; Maisonneuve, Amar, & Lowenfels, ; Meyer, Joshipura, Giovannucci, & Michaud, ; Shi et al, ; Zeng et al, ).…”

Section: Discussionmentioning

confidence: 99%

Calculus and survivorship in medieval London: The association between dental disease and a demographic measure of general health

Yaussy

DeWitte

2019

American J Phys Anthropol

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Objectives: Dental plaque is associated with a variety of systemic diseases and mortality risks in living populations. However, bioarchaeologists have not fully investigated the mortality risks associated with plaque (or its mineralized form, calculus) in the past. This study examines the relationship between survivorship and calculus in a medieval skeletal sample.Materials and methods: Our sample (n = 1,098) from four medieval London cemeteries, c. 1000-1540 CE, includes people who died under attritional (normal) and catastrophic (famine and plague) conditions. The associations between age and the presence of dental calculus on the permanent left first mandibular molar are assessed using binary logistic regression and Kaplan-Meier survival analysis. Results: The regression results indicate a significant negative relationship between age and calculus presence for individuals of all ages who died under normal mortality conditions and for adults who died under both normal and catastrophic conditions. Survival analysis reveals decreased survivorship for people of all ages with calculus under normal mortality conditions. Similarly, during conditions of catastrophic mortality, adult males with calculus suffered reduced survivorship compared to males without it, though there was no difference in survivorship between adult females with and without calculus. Conclusions: These results suggest that, as in modern populations, calculus accumulation in the inhabitants of medieval London reflects a greater risk of premature death. The evaluation of calculus, a potential measure of underlying frailty, in the context of a demographic measure of general health suggests that it might provide insights into health in past populations. K E Y W O R D S binary logistic regression, bioarchaeology, mortality, paleodemography, paleopathology, survival analysis

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Periodontal disease and susceptibility to breast cancer: A meta‐analysis of observational studies

Cited by 39 publications

References 55 publications

Relationship between periodontal disease and lung cancer: A systematic review and meta‐analysis

Relationship between periodontal disease and lung cancer: A systematic review and meta‐analysis

Hematopoietic and lymphatic cancers in patients with periodontitis: a systematic review and meta-analysis

Calculus and survivorship in medieval London: The association between dental disease and a demographic measure of general health

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