Periodontal tissue regeneration by recombinant human collagen peptide granules applied with β-tricalcium phosphate fine particles

Yoshino, Yuto; Miyaji, Hirofumi; Nishida, Erika; Kanemoto, Yukimi; Hamamoto, Asako; Sugaya, Tsutomu; Akasaka, Tsukasa

doi:10.1016/j.job.2023.01.002

Cited by 1 publication

(1 citation statement)

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“…The histological and histometric analysis of the effect of RTR ® (β-TCP) on the bonerepair process in surgically induced bone defects in rat tibiae revealed that RTR ® promotes bone neoformation. This finding aligns with those of prior studies on β-TCP formulations, which have been noted for their biocompatibility, biodegradation [9,[22][23][24][25], and osteoconductive capacities [10,22,[26][27][28][29]. The findings of Bueno et al [30] and Truedsson et al [31], highlighting the influence of the physical and chemical properties of β-TCP granules, such as shape, size, and porosity, on osteoblastic behavior, lend further credence to the theory that these characteristics are crucial for enhancing bone regeneration [32,33].…”

Section: Discussionsupporting

confidence: 88%

Histological Bone-Healing Evaluation of Critical-Size Defects Filled with β-Tricalcium Phosphate in Rat Tibiae

Vasques,

Bueno,

Guimarães

et al. 2024

Applied Sciences

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Bone defects may be a result of different pathologies and represent a challenge in different fields of dentistry. Techniques for the correction of bone defects involving the use of several types of grafts have been proposed. This study evaluated bone repair in rat tibiae after surgically created critical-size defects were filled with β-tricalcium phosphate (RTR®, Septodont, FR). Critical-size bone defects were created in the tibiae of 32 male Wistar rats, which were divided into four groups (n = 8): Control 30 days, Control 90 days, RTR® 30 days, and RTR® 90 days. After the experimental period, the animals were euthanized and specimens were collected, embedded in paraffin, serially cut, and stained with hematoxylin and eosin to evaluate the inflammatory and repair response. Two parameters were analyzed: neoformed bone tissue areas (NBA) and neoformed cortical areas (NCA). Statistical analysis was performed by ANOVA and Tukey’s test (p < 0.05). The RTR® group demonstrated superior bone healing compared with the control group in both analyzed parameters (NBA and NCA), with repair of the cortical bone and bone-tissue formation in the central region of the defect, which showed partial repair in the defect area (p < 0.05). RTR® enhanced bone neoformation in the adopted experimental model and may be a useful biomaterial to boost healing in cases of critical-size bone defects.

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