Periodontal Tissue Disposition of Azithromycin in Patients Affected by Chronic Inflammatory Periodontal Diseases

Blandizzi, Corrado; Malizia, Tecla; Lupetti, Antonella; Pesce, D.; Gabriele, Mario; Giuca, Maria Rita; Campa, Mario; Tacca, M. Del; Senesi, Sonia

doi:10.1902/jop.1999.70.9.960

Cited by 62 publications

(54 citation statements)

References 25 publications

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“…Another explication was the fact that this patient was the only one treated with the macrolide antibiotic azithromycin. Blandizzi et al showed in 1999 that azithromycin penetrated into both normal and pathological periodontal tissues (46), suggesting elimination of the targeted periodontal pathogenic bacteria for this patient.…”

Section: Discussionmentioning

confidence: 94%

Pseudomonas aeruginosa and Periodontal Pathogens in the Oral Cavity and Lungs of Cystic Fibrosis Patients: a Case-Control Study

Caldas

Gall

Revert³

et al. 2015

J Clin Microbiol

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bCystic fibrosis (CF) is the most frequent lethal genetic disease in the Caucasian population. Lung destruction is the principal cause of death by chronic Pseudomonas aeruginosa colonization. There is a high prevalence of oropharyngeal anaerobic bacteria in sputum of CF patients. This study was carried out due to the lack of results comparing subgingival periodontal pathogenic bacteria between the oral cavity and lungs in patients with CF in relation with P. aeruginosa presence. Our first goal was to detect P. aeruginosa in oral and sputum samples by culture and molecular methods and to determine clonality of isolates. In addition, subgingival periodontal anaerobic bacteria were searched for in sputum. A cross-sectional pilot case-control study was conducted in the CF Reference Center in Roscoff, France. Ten CF patients with a ⌬F508 homozygous mutation (5 chronically colonized [CC] and 5 not colonized [NC]) were enrolled. P. aeruginosa was detected in saliva, sputum, and subgingival plaque samples by real-time quantitative PCR (qPCR). Subsequently, periodontal bacteria were also detected and quantified in subgingival plaque and sputum samples by qPCR. In CC patients, P. aeruginosa was recovered in saliva and subgingival plaque samples. Sixteen P. aeruginosa strains were isolated in saliva and sputum from this group and compared by pulsed-field gel electrophoresis (PFGE). Subgingival periodontal anaerobic bacteria were found in sputum samples. A lower diversity of these species was recovered in the CC patients than in the NC patients. The presence of the same P. aeruginosa clonal types in saliva and sputum samples underlines that the oral cavity is a possible reservoir for lung infection.

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Section: Discussionmentioning

confidence: 94%

Pseudomonas aeruginosa and Periodontal Pathogens in the Oral Cavity and Lungs of Cystic Fibrosis Patients: a Case-Control Study

Caldas

Gall

Revert³

et al. 2015

J Clin Microbiol

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show abstract

“…It has been proven that the local concentration of some specifi c antibiotics mainly depends on gingival health status. Blandizzi et al (26) showed that after 3 days of administration of azithromycin (500 mg/day), its concentration in healthy gingiva reached to 3.3 -3.6 mg/kg and achieved a maximum concentration in 12 h after the last administration. Until day 4 -6, following the last administration, the concentration of azithromycin in healthy gum was signifi cantly higher than the plasma concentration.…”

Section: Discussionmentioning

confidence: 99%

Local concentration of systemic amoxicillin and metronidazole in healthy and inflamed gingiva: a comparative in vivo study

Amid

Tabeie²,

Kadkhodazadeh³

et al. 2012

Drug Metabolism and Drug Interactions

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“…[23][24][25][26][27][28][29] Azithromycin shows good bacteriostatic in-vitro activity against a wide variety of micro-organisms found in the mouth, 30 with a broad spectrum of activity towards anaerobic bacteria as well as Gram-negative bacilli. 31 One of the problems associated with using systemic antimicrobials for the adjunctive management of odontogenic infections is patient compliance.…”

Section: Therapeutic Usesmentioning

confidence: 99%

Azithromycin and dentistry — a useful agent?

Addy

Martin²

2004

Br Dent J

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Periodontal Tissue Disposition of Azithromycin in Patients Affected by Chronic Inflammatory Periodontal Diseases

Abstract: The present results indicate a marked penetration of azithromycin into both normal and pathological periodontal tissues, suggesting that azithromycin represents a promising option in both adjunctive and prophylactic treatments of chronic inflammatory periodontal diseases.

Cited by 62 publications

References 25 publications

Pseudomonas aeruginosa and Periodontal Pathogens in the Oral Cavity and Lungs of Cystic Fibrosis Patients: a Case-Control Study

Pseudomonas aeruginosa and Periodontal Pathogens in the Oral Cavity and Lungs of Cystic Fibrosis Patients: a Case-Control Study

Local concentration of systemic amoxicillin and metronidazole in healthy and inflamed gingiva: a comparative in vivo study

Azithromycin and dentistry — a useful agent?

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