Patients with CP had higher levels of miR-146a than healthy individuals, accompanied by reduced levels of TNF-α and IL-6. A positive relationship between miR-146a levels and clinical parameters suggests a pathophysiologic role of miR-146a in CP.

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The aim of this study was to assess stress and strain patterns in cortical and cancellous bones surrounding newly designed dental implants with different thread patterns. Static loading of dental implants has been well studied, but studies on dynamic loading and fatigue analysis of dental implants are scarce. This study analyzed the static, dynamic, and fatigue behaviors of dental implants using finite element analysis (FEA). Two models of dental implants were analyzed in this study. Model A was a tapered implant with V-shaped threads and model B was a tapered implant with microthreads in the uppermost region and V-shaped threads in the rest of the body. Two types of loading conditions were simulated in an FEA model and stress and strain patterns in the surrounding bone were analyzed. Dynamic loading increased the level of stress by 5-10% compared with static loading. Both implants showed acceptable results under static and dynamic loadings, but the second implant with microthreads caused lower stress and strain in cortical and cancellous bones. Dynamic and fatigue analyses can provide a more realistic understanding of the function of dental implants. Replacing the uppermost threads with microthreads can lead to more desirable stress patterns in bone, as well as a higher safety factor and longevity.

The aim of this study was to evaluate the effects of exposing dental implants to the maxillary sinus cavity. This is a retrospective study. Thirteen patients with 18 implants that had radiographic evidence of implant exposure to the maxillary sinuses participated in this study. We evaluated the patient's radiographs immediately after implant insertion and 12 months after operation with the patient's clinical signs and symptoms due to sinusitis. Thirteen patients with 18 implants in the maxillary sinus had no signs and symptoms of sinusitis. Radiography showed thickening of the sinus membranes in 2 patients. All penetrated implants were successfully integrated, and there were no radiographic signs of bone loss or other complications.The exposure of implants to the maxillary sinuses caused no problems in the maxillary sinuses, and bone formation occurred in THE maxillary floor when penetration of maxillary sinuses occurred without tearing of the membrane.