Periodontal repair in dogs: space‐providing ePTFE devices increase rhBMP‐2/ACS‐induced bone formation

Wikesjö, Ulf M.E.; Xiropaidis, Andreas V.; Thomson, Robert C.; Cook, Alonzo D.; Selvig, Knut A.; Hardwick, W. Ross

doi:10.1034/j.1600-051x.2003.00364.x

Cited by 46 publications

(35 citation statements)

References 52 publications

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“…Cementum regeneration was also stimulated by rhBMP-2, although not significantly in some reports [104,107,108]. Ankylosis was also occasionally reported to affect periodontal regeneration associated with rhBMP-2 treatment [102,103,109]. Ankylosis (fusion of the tooth and the alveolar bone) is more frequent in the cervical area of the exposed root and seems to be associated with rapid osteogenesis, especially in submerged tooth models.…”

Section: Growth Factor Applications For Oral and Periodontal Tissue Ementioning

confidence: 96%

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Growth factor delivery for oral and periodontal tissue engineering

Kaigler

Cirelli

Giannobile

2006

Expert Opinion on Drug Delivery

164

153

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The treatment of oral and periodontal diseases and associated anomalies accounts for a significant proportion of the healthcare burden, with the manifestations of these conditions being functionally and psychologically debilitating. Growth factors are critical to the development, maturation, maintenance and repair of craniofacial tissues, as they establish an extracellular environment that is conducive to cell and tissue growth. Tissue-engineering principles aim to exploit these properties in the development of biomimetic materials that can provide an appropriate microenvironment for tissue development. These materials have been constructed into devices that can be used as vehicles for delivery of cells, growth factors and DNA. In this review, different mechanisms of drug delivery are addressed in the context of novel approaches to reconstruct and engineer oral-and tooth-supporting structures, namely the periodontium and alveolar bone.

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Section: Growth Factor Applications For Oral and Periodontal Tissue Ementioning

confidence: 96%

“…BMPs -2, -4, -7 and -12 have all been evaluated for periodontal and peri-implant bone regeneration [67]. From this group of proteins, BMP-2 has been the most studied for bone and periodontal regenerative treatment [101][102][103][104][105][106].…”

Section: Growth Factor Applications For Oral and Periodontal Tissue Ementioning

confidence: 99%

Growth factor delivery for oral and periodontal tissue engineering

Kaigler

Cirelli

Giannobile

2006

Expert Opinion on Drug Delivery

164

153

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“…The cementum is removed, and notches are placed to mark the bone level at the time of surgical resection. Reducing the crowns of teeth allows for a submerged repositioning of the flap for situations where the oral environmental factors can affect flap dehiscence (Wikesjö et al, 2003c). In the acute defect model, lesions are immediately treated with NMF before wound closure.…”

Section: Surgically Created Periodontal Defectsmentioning

confidence: 99%

“…However, acute periodontal defects fail to reproduce the microbiological and inflammatory conditions present in periodontal disease. Surgical periodontal defects have been largely used to evaluate periodontal regeneration following placement of barrier membranes (Wikesjö et al, 2003b), biologics such as BMPs (Giannobile et al, 1998;Wikesjö et al, 2003cWikesjö et al, , 2004, PDGF (Park et al, 1995), and other biomaterials Chen et al, 2006). Histomorphometric endpoint analyses quantify the length of the regenerated cementum, bone, PDL, and junctional epithelium (Wikesjö et al, 2003a;Murano et al, 2006).…”

Section: Surgically Created Periodontal Defectsmentioning

confidence: 99%

Pre-clinical Models for Oral and Periodontal Reconstructive Therapies

et al. 2009

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The development of new medical formulations (NMF) for reconstructive therapies has considerably improved the available treatment options for individuals requiring periodontal repair or oral implant rehabilitation. Progress in tissue engineering and regenerative medicine modalities strongly depends on validated pre-clinical research. Preclinical testing has contributed to the recent approval of NMF such as GEM 21S ® and INFUSE ® bone grafts for periodontal and oral regenerative therapies. However, the selection of a suitable preclinical model for evaluation of the safety and efficacy of a NMF remains a challenge. This review is designed to serve as a primer to choose the appropriate pre-clinical models for the evaluation of NMF in situations requiring periodontal or oral reconstruction. Here, we summarize commonly used pre-clinical models and provide examples of screening and functional studies of NMF that can be translated into clinical use.

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“…Quando se associa a BMP com um carreador, propicia-se imobilidade da proteína na área, diminui-se a quantidade de BMP necessária e o tempo para que ocorra a indução 45 . Dentre os materiais testados em associação à BMP, ressaltamos: hidroxiapatita 35,46 ; esponjas de colágeno reabsorvível 16,21,25,35,[46][47][48] ; politetrafluoretileno expandido 49,50 ; osso bovino 16,21,[51][52][53][54] e osso autógeno 55 . Os carreadores mais utilizados são a hidroxiapatita e o colágeno, pois são compostos presentes na estrutura óssea, absorvendo naturalmente a BMP 56 .…”

Section: Revisão De Literaturaunclassified

Aplicabilidade de rhBMP-2 em diferentes técnicas de enxertia

Pasquali

Casagrande

Ponte

et al. 2015

Rev. da Fac. de Odontologia, UPF

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IntroduçãoTécnicas de enxerto ósseo surgiram para suprir perdas de volume nos sentidos horizontais e verticais, em pacientes com quantidade óssea reduzida, visto que o sucesso de reabilitações bucofaciais depende não somente do treinamento e da experiên-cia do profissional, mas também da quantidade e da densidade de osso disponível 1,2 . O tecido ósseo tem as seguintes propriedades de reparação e formação: osteogênese que é a formação óssea mediada por osteoblastos; osteoindução, mediada por BMPs, induzindo a formação óssea ectópica por meio de células mesenquimais; e osteocondução, relacionado à composição e à estrutura (arcabouço). Tais propriedades têm papel importante nos diferentes mecanismos de formação óssea dos enxertos, os quais podem ter diferentes origens: autógenos, homógeno, xenógeno e aloplásticos [3][4][5][6] . Osso autógeno ainda é o "padrão ouro" para procedimentos de reconstrução 7 , apesar da grande morbidade 8 . Em estudos recentes, pesquisadores isolaram a principal proteína para regeneração óssea, a proteína morfogenética (BMP), e derivaram sinteticamente a Proteínas Morfogenéticas Ósseas Recombinantes Humanas (rhBMP-2). Essa proteína funciona como regulador de crescimento e diferenciação celular, induzindo a transformação de células-tronco em células produtoras de tecidos ósseos ou vasculares 3,6 . Objetivo: analisar a influência da rhBMP-2 em enxertos bucofaciais, apresentando pesquisas recentes, feitas em animais e em humanos, bem como as diferentes metodologias de aplicabilidade clínica e os resultados obtidos por seus autores. Revisão de literatura: para que seja possível a instalação de implantes ou a cor-

show abstract

Periodontal repair in dogs: space‐providing ePTFE devices increase rhBMP‐2/ACS‐induced bone formation

Abstract: The results suggest that the novel space-providing, macroporous ePTFE device appears suitable as a template to define rhBMP-2/ACS-induced alveolar bone formation.

Cited by 46 publications

References 52 publications

Growth factor delivery for oral and periodontal tissue engineering

Growth factor delivery for oral and periodontal tissue engineering

Pre-clinical Models for Oral and Periodontal Reconstructive Therapies

Aplicabilidade de rhBMP-2 em diferentes técnicas de enxertia

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