Periodontal disease could be a potential risk factor for non-alcoholic fatty liver disease: An 11-year retrospective follow-up study

Shin, Hye-Sun; Hong, Min-Hee; Moon, Ja-Young; Sim, Seon-Ju

doi:10.1007/s00784-022-04518-6

Cited by 9 publications

(7 citation statements)

References 38 publications

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“…Treatment and prevention of periodontal disease may be important in reducing the risk of NAFLD. [35] Data on the treatment of periodontitis in studies has shown promising results for obesity, diabetes, and NASH, but the data are not yet at the desired level for humans. [36] Further to that it was stated that the presence of hepatobiliary pathology in substance abusers and smokers enhances the risk of periodontal disease.…”

Section: Periodontal Problems and Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

Non-Alcoholic Fatty Liver and Periodontal Disease: Is there a Relationship? A Contemporary Review

Hatipoglu

2024

J Inonu Liver Transpl Inst

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T he Non-alcoholic fatty liver disease (NAFLD) it's a term used for several conditions caused by fat accumulation in the liver. One-fourth of the world's population is faced with this clinical situation. It is mostly seen in South America and the Middle East, and least in Africa. [1] Nevertheless, when considering its prevalence within the community, this malady emerges as one of the most frequently encountered liver diseases, demonstrating a notable association with elevated rates of liver-related mortality and morbidity. [2] By definition, NAFLD is a clinical picture in which insulin resistance, histopathological more than 5% steatosis of hepatocytes, or dense fat fractions by radiographic techniques are detected. This clinical situation is examined under two main headings non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (steatosis coexists with liver-cell injury and inflammation). [3,4] NAFLD has 4 stages for developing; simple fatty liver (steatosis), non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis, and may liver cancer. [5] In advanced phases, this may result in liver transplantation. The patients with NAFLD show similar histological damage to alcoholic liver disease. [6] Oxidative and inflammatory responses play crucial roles in the shared pathogenesis of both NAFLD and nonalcoholic NASH. [7] Lifestyle is an important point for developing this disease.Periodontal disease is a common inflammatory disease and is known to be related to other systemic diseases. This bidirectional relation between periodontal disease and other disease processes has led to outstanding research recently. In addition, periodontal disease has been advocated to exacerbate metabolic disorders including non-alcoholic fatty liver disease (NAFLD). In this traditional review, general characteristics of periodontal diseases, general characteristics of NAFLD/ Nonalcoholic steatohepatitis (NASH), and their causality were discussed for treatment providers. The collected data significantly corroborate a greater incidence of periodontal disease among individuals with NAFLD in comparison to the general healthy population. Healthcare professionals need to be aware of the association between NAFLD and periodontal disease thus patient management effectiveness can be enhanced.

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Section: Periodontal Problems and Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

Non-Alcoholic Fatty Liver and Periodontal Disease: Is there a Relationship? A Contemporary Review

Hatipoglu

2024

J Inonu Liver Transpl Inst

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“… 5 Epidemiological studies have demonstrated that periodontitis is a potential risk factor for NAFLD. 6 A recent investigation suggested that higher clinical attachment loss is associated with an increased incidence of liver fibrosis in obese adults with NAFLD. 7 It was also demonstrated that periodontal pathogens can aggravate the progression of NAFLD accompanied by enhanced steatosis.…”

Section: Introductionmentioning

confidence: 99%

Periodontitis salivary microbiota exacerbates nonalcoholic fatty liver disease in high-fat diet-induced obese mice

Wang¹,

Li²,

Qian³

et al. 2023

iScience

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“…In recent years, several studies have shown an independent association between periodontal disease and NAFLD [11][12][13]. Moreover, periodontitis has been implicated in the pathogenesis of liver fibrosis [14] possibly through translocation of oral microbiota and persistent low-grade systemic inflammation [15].…”

Section: Introductionmentioning

confidence: 99%

Can Frequent Toothbrushing Reduce the Risk of Cirrhosis among Patients with Nonalcoholic Fatty Liver Disease? Hints from a Registry-Based Study

Keklikkıran¹,

Stepanova²,

Younossi³

et al. 2023

Dig Dis

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Introduction: While poor oral hygiene has been previously associated with an increased risk of non-alcoholic fatty liver disease (NAFLD), its association with hepatic fibrosis remains unclear. Here, we sought to analyze if toothbrushing frequency, an easy-to-assess indicator of oral health habits, would be associated with liver stiffness measurement (LSM) by transient elastography (TE) in patients with an established diagnosis of NAFLD. Methods: In this registry-based study, LSM was measured in 1156 patients with NAFLD and analyzed in relation to the self-reported daily frequency of toothbrushing. LSM values ≥12 kPa were considered as indicative of cirrhosis. Results: A trend towards a stepwise decrease (cross-sectional p = 0.13) in LSM was found in patients who reported having their teeth brushed more frequently: less than once a day (10.6 ± 8.6 kPa; 13% of the study sample), once a day (9.95 ± 8.40 kPa; 40%), twice a day (9.21 ± 7.63 kPa; 43%), and after every meal (8.91 ± 5.30 kPa; 4%). Patients who brushed their teeth less than once a day had a significantly higher prevalence of LSM values ≥12 kPa (p < 0.05). In multivariable logistic regression analysis, the association of LSM values ≥ 12 kPa with toothbrushing habits remained statistically significant for less than once a day (odds ratio = 1.69, 95% confidence interval = 1.07−2.66, p = 0.02) with reference to twice a day or after every meal. Conclusion: Among patients with NAFLD, there is an independent association between brushing teeth less than once a day and TE-established cirrhosis.

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Periodontal disease could be a potential risk factor for non-alcoholic fatty liver disease: An 11-year retrospective follow-up study

Cited by 9 publications

References 38 publications

Non-Alcoholic Fatty Liver and Periodontal Disease: Is there a Relationship? A Contemporary Review

Non-Alcoholic Fatty Liver and Periodontal Disease: Is there a Relationship? A Contemporary Review

Periodontitis salivary microbiota exacerbates nonalcoholic fatty liver disease in high-fat diet-induced obese mice

Can Frequent Toothbrushing Reduce the Risk of Cirrhosis among Patients with Nonalcoholic Fatty Liver Disease? Hints from a Registry-Based Study

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