Periodontal disease and its impact on general health in Latin America. Section V: Treatment of periodontitis

Fischer, Ricardo Guimarães; Lira-Júnior, Ronaldo; Retamal‐Valdes, Belén; Figueiredo, Luciene Cristina; Malheiros, Zilson; Stewart, Bernal; Feres, Magda

doi:10.1590/1807-3107bor-2020.vol34.0026

Cited by 82 publications

(47 citation statements)

References 67 publications

(93 reference statements)

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“…Non-surgical periodontal treatment can show therapeutic effects in mild to moderate periodontal disease, whereas surgical periodontal therapy is needed in progressive disease conditions [ 10 ]. Supplementary to mechanical debridement in periodontal treatment, various drug delivery methods, mouth rinses, irrigating solutions, and long-term drug release systems are commonly used for therapeutic agent administration [ 10 , 12 ]. Furthermore, routine periodontal therapy combined with an adjunctive therapeutic mediator has been shown to greatly improve patient outcomes as compared to mechanical debridement only [ 10 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Salvadora persica: Nature’s Gift for Periodontal Health

Mekhemar

Geib²,

Kumar

et al. 2021

Antioxidants

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Salvadora persica (SP) extract, displays very valuable biotherapeutic capacities such as antimicrobial, antioxidant, antiparasitic and anti-inflammatory effects. Numerous investigations have studied the pharmacologic actions of SP in oral disease therapies but its promising outcomes in periodontal health and treatment are not yet entirely described. The current study has been planned to analyze the reported effects of SP as a support to periodontal therapy to indorse regeneration and healing. In consort with clinical trials, in vitro investigations show the advantageous outcomes of SP adjunctive to periodontal treatment. Yet, comprehensive supplementary preclinical and clinical investigations at molecular and cellular levels are indispensable to reveal the exact therapeutic mechanisms of SP and its elements for periodontal health and therapy.

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Section: Introductionmentioning

confidence: 99%

Salvadora persica: Nature’s Gift for Periodontal Health

Mekhemar

Geib²,

Kumar

et al. 2021

Antioxidants

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“…Non-surgical handling can be effective in mild to moderate periodontitis while surgical action is important in progressive conditions [ 10 ]. Adjunctive to the mechanical scaling and root planning in the treatment of periodontal diseases, confined systems of drug delivery, mouth washes, irrigations and devices for sustained drug release are used regularly for conveyance of therapeutic agents [ 10 , 12 ]. Furthermore, it has been reported that regular periodontal treatment along with the use of an adjunctive therapeutic mediator can improve patient outcomes significantly compared to mechanical treatment alone [ 10 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Nigella sativa and Thymoquinone: A Natural Blessing for Periodontal Therapy

2020

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Thymoquinone (TQ), the chief active constituent of Nigella sativa (NS), shows very valuable biomedical properties such as antioxidant, antimicrobial, anticancer, anti-inflammatory, antihypertensive, hypoglycemic, antiparasitic and anti-asthmatic effects. Several studies have examined the pharmacological actions of TQ in the treatment of oral diseases but its potential role in periodontal therapy and regeneration is not yet fully defined. The present investigation has been designed to review the scientific studies about the effects of TQ as an adjunct to periodontal treatment to promote healing and periodontal regeneration. Along with clinical experiments, in vitro studies exhibit the beneficial effects of TQ during periodontal therapy. Nevertheless, additional comprehensive clinical and preclinical studies at cellular and molecular levels are essential to examine the particular action mechanisms of Nigella sativa and its elements, particularly TQ, during periodontal treatment or regeneration.

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“…[24] Periodontitis is an in ammatory disorder raised by the accumulation of speci c bacterial pathogens and the destruction of host immune responses [25]. The clinical ndings of periodontitis included gingival bleeding, tooth mobility, and nally the loss of the tooth, which are associated with a negative impact on Oral Health-Related Quality of Life [26]. Similarities could be discovered between Periodontitis and SSc.…”

Section: Discussionmentioning

confidence: 99%

Oral Manifestations of Patients with Systemic Sclerosis: A Meta-analysis for Case-controlled Studies.

Zhang

Zhu

et al. 2021

Preprint

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Background：Systemic sclerosis (SSc) is a multisystem rheumatic disease. Orofacial manifestations are commonly in SSc but maybe usually ignored and overshadowed by other systemic complications. Multiple comparative studies have been conducted to investigate the possible links between SSc and oral manifestations. The present study aimed to investigate the oral health status in patients with SSc. Methods：Pubmed, Embase, Web of Science, and Scopus were searched up to July 2020. Following outcomes were evaluated: Probing depth (PD), Attachment loss (AL), Bleeding on probing (BOP), Number or percentage of Sites with PD ≥ 4 mm, Prevalence of periodontitis, Number of teeth, Decayed Teeth, Missing teeth, Filled teeth, DMFT index, and the interincisal distance. Newcastle-Ottawa Scale (NOS) were applied for quality assessment. The statistical analysis was processed using the software STATA.Results: 11 eligible studies were included. The maximum interincisor distance was significantly restricted in SSc patients (SMD -1.061; 95%CI [-1.546, -0.576]; Z=4.29, P=0.000).The prevalence of Periodontitis (OR 7.007; 95%CI [3.529,13.915]; Z=5.56, P=0.000) , PD (SMD 3.101; 95%CI [1.374, 4.829]; Z=3.52, P=0.000), AL(SMD 2.584; 95%CI [0.321, 4.846]; Z=2.24, P=0.025) , sites with PD≥4mm (SMD 2.071 ; 95%CI [0.267, 3.875]; Z=2.25, P=0.024) and the number of decayed teeth (SMD, 0.186; 95%CI [0.007, 0.365]; Z= 2.04, P=0.041) were increased significantly in SSc population in comparison with the controls. Conclusions: SSc patients have limited mouth opening, higher periodontitis prevalence, and worse periodontal status, as well as an increased number of decayed teeth. Routinely oral hygiene instruction and initial periodontal treatment is recommended for SSc patients.

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Periodontal disease and its impact on general health in Latin America. Section V: Treatment of periodontitis

Abstract: Ricardo Guimarães FISCHER (a) Ronaldo LIRA JUNIOR (b) Belén RETAMAL-VALDES (c) Luciene Cristina de FIGUEIREDO (c,d) Zilson MALHEIROS (d,e) Bernal STEWART (d,e) Magda FERES (c,d)

Cited by 82 publications

References 67 publications

Salvadora persica: Nature’s Gift for Periodontal Health

Salvadora persica: Nature’s Gift for Periodontal Health

Nigella sativa and Thymoquinone: A Natural Blessing for Periodontal Therapy

Oral Manifestations of Patients with Systemic Sclerosis: A Meta-analysis for Case-controlled Studies.

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