Periodontal disease and bacterial vaginosis as genetic and environmental markers for the risk of spontaneous preterm labor and preterm birth

Sanu, Olaleye; Lamont, Ronald F.

doi:10.3109/14767058.2010.545930

Cited by 24 publications

(16 citation statements)

References 138 publications

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“…For example, the prevalence of bacterial vaginosis is higher among African American women (51.6%) than Caucasian women (23.2%; Meis et al, 1995). Antimicrobial treatment results in limited improvement in outcomes (Sanu & Lamont, 2011), suggesting that infection may initiate an inflammatory process that continues despite treatment. Further, Gomez et al (2010) found evidence of a gene–environment interaction between bacterial vaginosis infection and single nucleotide polymorphisms (SNPs) on inflammation-related genes that resulted in increased risk of PTB among a predominantly African American cohort of women.…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review of DNA Methylation and Preterm Birth in African American Women

Barcelona

Wright

Agaba

et al. 2016

Biological Research For Nursing

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Background The causes of many cases of preterm birth (PTB) remain enigmatic. Increased understanding of how epigenetic factors are associated with health outcomes has resulted in studies examining DNA methylation (DNAm) as a contributing factor to PTB. However, few studies on PTB and DNAm have included African American women, the group with the highest rate of PTB. Methods The objective of this review was to systematically analyze the existing studies on DNAm and PTB among African American women. Results Studies (N = 10) were limited by small sample size, cross-sectional study designs, inconsistent methodologies for epigenomic analysis, and evaluation of different tissue types across studies. African Americans comprised less than half of the sample in 50% of the studies reviewed. Despite these limitations, there is evidence for an association between DNAm patterns and PTB. Conclusions Future research on DNAm patterns and PTB should use longitudinal study designs, repeated DNAm testing, and a clinically relevant definition of PTB and should include large samples of high-risk African American women to better understand the mechanisms for PTB in this population.

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Section: Introductionmentioning

confidence: 99%

A Systematic Review of DNA Methylation and Preterm Birth in African American Women

Barcelona

Wright

Agaba

et al. 2016

Biological Research For Nursing

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“…With respect to bacterial vaginosis, the timing and the choice of antibiotic administration might partly explain the conflicting results. The use of scaling and/or root planning for women with periodontal disease appears to reduce the risk of preterm birth, but routine administration of antibiotics has not demonstrated any impact on preterm birth and the contribution of periodontal disease and bacterial vaginosis are needed [30].…”

Section: Is It Effective To Give Antibiotics For Pd In Pregnancy?mentioning

confidence: 99%

Periodontal Disease and Pregnancy Outcome. Are we Still in the Same Place?

Gabriela¹

2017

JDHODT

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There is a general concern about the relationship between periodontal disease and pregnancy, although the lack of evidence in the studies is significant, there is a population that must receive attention. It is important that dentists and gynecoobstetrics work together to keep oral health in pregnant women and also improve their oral hygiene. This mini-review highlights the importance of periodontal disease, pathogens involved, treatment and dental management in pregnant women.

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“…30,36 BV has been implicated as a risk factor for PTB and associated morbidities. [37][38][39][40][41] The racial disparity in rates of PTB is mirrored in rates of BV: 11% of Caucasian women deliver preterm and 10 to 20% of Caucasians have BV, 18% of African American women deliver preterm and 30 to 50% of African American women have BV. 21 Thus, BV doubles the relative risk for PTB in the Caucasian population, but this disorder more than triples the risk in African American women.…”

Section: Defining the Microbiome Of Preterm Birth Vaginal Microbiomementioning

confidence: 99%

Microbiome in Parturition and Preterm Birth

Mysorekar¹,

Cao

2014

Semin Reprod Med

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Preterm birth (PTB), defined as a live birth between 20 and 37 weeks of gestation, is a significant public health concern, affecting 12.7% of all births in the United States. PTB is a leading cause of perinatal morbidity and mortality in both developed and developing countries 1,2 ; 27% of neonatal deaths are primarily attributable to PTB, and an additional 36% of neonatal deaths secondary to opportunistic infections (e.g., sepsis, pneumonia) are attributable to prematurity. Of those infants that survive, PTB is an independent risk factor for motor (cerebral palsy) and sensory (retinopathy and neuropathy) deficits, learning disabilities, and respiratory disorders (bronchopulmonary dysplasia). In fact, nearly 50% of preterm babies suffer from long-term neurologic sequelae. 3 In addition to the global PTB, rate of prematurity is the astounding financial and social burden on the affected families. PTB-associated costs have been estimated in 2005 to exceed $26 billion. 4 PTB-associated morbidity and mortality is tightly linked to the gestational age of the fetus. Therefore, PTBs are classified into extremely preterm (more than 20 weeks but fewer than 28 weeks of gestation), very preterm (28 weeks through 32 weeks), and moderate-to-late preterm (more than 32 weeks but less than 37 weeks). Over the past 25 years, the rate of PTB in the United States has increased by 36%, and most of the increase has been in moderate-to-late PTBs. Increasing maternal age, rising rates of multiple gestations due to the use of assisted reproductive technologies, and a concomitant increase in indicated PTBs are major contributing factors driving this increase. 5 PTB causes are generally grouped into the following categories: 30% are associated with preterm premature rupture of membranes, 45 to 50% are idiopathic, and 15 to 20% are medically indicated. 6 However, the underlying etiologies (e. g., genetic factors, socioeconomic factors, or environmental factors) and mechanisms which may trigger various PTB subtypes remain largely unknown. Furthermore, to date, clinical interventions to reduce PTB have focused largely on specific risk factors, rather than on molecular-cellular etiology, and have arguably had less than optimal impact on elucidating PTB mechanisms. 7 Because PTB is currently the most significant problem in maternal-fetal health, it is of the greatest importance to determine its causes, which will allow the field to develop novel methods of prevention and treatment. This review will focus on microbial (bacterial) etiologies for PTB. Keywords► pregnancy ► microbiome ► preterm birth ► parturition ► bacteria AbstractPreterm parturition is a one of the most significant global maternal-child health problem. In recent years, there has been an explosion in reports on a role for microbiomes (i.e., a microbial biomass) on a plethora of physiologic and pathologic human conditions. This review aims to describe our current understanding of the microbiome and its impact on parturition, with particular emphasis on preterm birth. We will focu...

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Periodontal disease and bacterial vaginosis as genetic and environmental markers for the risk of spontaneous preterm labor and preterm birth

Abstract: Prospective studies evaluating the association of gene polymorphism with preterm birth, and the contribution of periodontal disease and bacterial vaginosis are needed.

Cited by 24 publications

References 138 publications

A Systematic Review of DNA Methylation and Preterm Birth in African American Women

A Systematic Review of DNA Methylation and Preterm Birth in African American Women

Periodontal Disease and Pregnancy Outcome. Are we Still in the Same Place?

Microbiome in Parturition and Preterm Birth

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