Periodic Mesoporous Organosilica‐Based Nanocomposite Hydrogels as Three‐Dimensional Scaffolds

Kehr, Nermin Seda; Prasetyanto, Eko Adi; Benson, Kathrin; Ergün, Bahar; Galstyan, Anzhela; Galla, Hans‐Joachim

doi:10.1002/anie.201206951

Cited by 72 publications

(56 citation statements)

References 61 publications

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“…Up to date several bioactive ligands, [4] for example, carbohydrates [5] or peptides [6] adsorbed or immobilized covalently at the substrate surfaces have been used to introduce biocompatibility and enhance cell adhesion and cell growth behavior. [4][5][6][7] Currently, we [8] and other groups [9][10][11][12] used enantiomers of bioactive molecules for the functionalization of the 2D surface of materials and studied the cell adhesion behavior on enantiomerically functionalized surfaces. In a pioneer work Sun et al [9] and Addadi and coworkers [10] reported the different adhesion behavior of cells on enantiomerically functionalized surfaces, for instance, chiral polymers.…”

Section: Introductionmentioning

confidence: 99%

Cell Adhesion Behavior in 3D Hydrogel Scaffolds Functionalized with D‐ or L‐Aminoacids

Benson

Galla

Kehr

2014

Macromolecular Bioscience

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Alginate hydrogels functionalized with D-, or L-penicillamine (D-, L-PEN-Alg) are used as new 3D scaffolds for cell adhesion studies. The cells recognize and show different adhesion properties in the respective 3D hydrogel scaffolds. C-6-glioma and endothelial cells show higher affinity to the D-PEN than to the L-PEN functionalized 3D alginate hydrogel scaffold. The cultivated cells are harvested from the hydrogel and are reused, for example, for cell growth experiments on 2D surfaces to prove their viability as well.

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Section: Introductionmentioning

confidence: 99%

Cell Adhesion Behavior in 3D Hydrogel Scaffolds Functionalized with D‐ or L‐Aminoacids

Benson

Galla

Kehr

2014

Macromolecular Bioscience

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“…Ethanebridged MONs with a particle diameter of 530 -550 nm were used to prepare nanocomposite hydrogels, which could be used as three-dimensional scaffolds. [ 281 ] It was found that the embedded MONs could enhance the mechanical and biological performances of the hydrogel. For instance, RGD-functionalized PMO-alginate hydrogels showed almost four times higher affi nity with HeLa and endothelial cells than that of simple alginate hydrogel.…”

Section: Mons For Regenerative Medicinementioning

confidence: 99%

Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

2016

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Organic-inorganic hybrid materials aiming to combine the individual advantages of organic and inorganic components while overcoming their intrinsic drawbacks have shown great potential for future applications in broad fields. In particular, the integration of functional organic fragments into the framework of mesoporous silica to fabricate mesoporous organosilica materials has attracted great attention in the scientific community for decades. The development of such mesoporous organosilica materials has shifted from bulk materials to nanosized mesoporous organosilica nanoparticles (designated as MONs, in comparison with traditional mesoporous silica nanoparticles (MSNs)) and corresponding applications in nanoscience and nanotechnology. In this comprehensive review, the state-of-art progress of this important hybrid nanomaterial family is summarized, focusing on the structure/composition-performance relationship of MONs of well-defined morphology, nanostructure, and nanoparticulate dimension. The synthetic strategies and the corresponding mechanisms for the design and construction of MONs with varied morphologies, compositions, nanostructures, and functionalities are overviewed initially. Then, the following part specifically concentrates on their broad spectrum of applications in nanotechnology, mainly in nanomedicine, nanocatalysis, and nanofabrication. Finally, some critical issues, presenting challenges and the future development of MONs regarding the rational synthesis and applications in nanotechnology are summarized and discussed. It is highly expected that such a unique molecularly organic-inorganic nanohybrid family will find practical applications in nanotechnology, and promote the advances of this discipline regarding hybrid chemistry and materials.

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Section: Nanocomposite Hydrogels Of Nanomaterials As Biomaterialsmentioning

confidence: 99%

“…After certain incubation times the cells in the hydrogel were analyzed by fluorescence microscope. Fluorescence microscopy images showed that the cells in the used NC hydrogel were stained by the fluorescence dye molecules which were released from the pores of PMOs . Recently, silica NPs incorporated into collogen hydrogels were described.…”

Section: Nanocomposite Hydrogels Of Nanomaterials As Biomaterialsmentioning

confidence: 99%

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Self-assembled Monolayers and Nanocomposite Hydrogels of Functional Nanomaterials for Tissue Engineering Applications

2014

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In biotechnology, SAMs and NC hydrogels of functional nanomaterials are of high interest as 2D and 3D cell culture systems, respectively, to mimic natural ECM and to control cell behaviors. Advanced biotechnological approaches often use nanoscale topography together with suitable surface functionalization, as a model of ECM, to control cell behaviors and tissue formation. SAMs of NMs are effective ECM models as 2D surfaces due to their larger nanostructured surface areas which provide higher molecular density by functionalization on a planar substrate than molecular SAMs. Additionally, NC hydrogels, produced by cross-linking of organic polymers with NMs, are excellent candidates as 3D cell culture systems owing to their optical, cell-compatibility and the extraordinary mechanical properties.

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Periodic Mesoporous Organosilica‐Based Nanocomposite Hydrogels as Three‐Dimensional Scaffolds

Cited by 72 publications

References 61 publications

Cell Adhesion Behavior in 3D Hydrogel Scaffolds Functionalized with D‐ or L‐Aminoacids

Cell Adhesion Behavior in 3D Hydrogel Scaffolds Functionalized with D‐ or L‐Aminoacids

Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

Self-assembled Monolayers and Nanocomposite Hydrogels of Functional Nanomaterials for Tissue Engineering Applications

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