Perinephritis hypertension in Macaca fascicularis (cynomolgus monkey)

DeForrest, Jack M.; Scalese, Robert J.; Oehl, R. S.; Waldron, Thomas L.; Mitch, Susan; Brittain, Russell J.; Free, Charles A.; Asaad, Magdi M.; Burkett, Dennis E.

doi:10.1097/00004872-198909000-00011

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et al. 2005

Journal of Laboratory and Clinical Medicine

162

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Animal Models of Hypertension: A Scientific Statement From the American Heart Association

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Kurtz²,

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et al. 2019

Hypertension

214

176

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Hypertension is the most common chronic disease in the world, yet the precise cause of elevated blood pressure often cannot be determined. Animal models have been useful for unraveling the pathogenesis of hypertension and for testing novel therapeutic strategies. The utility of animal models for improving the understanding of the pathogenesis, prevention, and treatment of hypertension and its comorbidities depends on their validity for representing human forms of hypertension, including responses to therapy, and on the quality of studies in those models (such as reproducibility and experimental design). Important unmet needs in this field include the development of models that mimic the discrete hypertensive syndromes that now populate the clinic, resolution of ongoing controversies in the pathogenesis of hypertension, and the development of new avenues for preventing and treating hypertension and its complications. Animal models may indeed be useful for addressing these unmet needs.

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Perinephritis hypertension in Macaca fascicularis (cynomolgus monkey)

Cited by 4 publications

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Programming Hypertension—Animal Models

Programming Hypertension—Animal Models

Animal models of hypertension: An overview

Animal Models of Hypertension: A Scientific Statement From the American Heart Association

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