Early Life Origins of Health and Disease
DOI: 10.1007/0-387-32632-4_9
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Programming Hypertension—Animal Models

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Cited by 10 publications
(8 citation statements)
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“…Possible explanations for these disparities include lack of catch-up growth as observed in our model (65) or may reflect stress induced by the method employed to measure arterial pressure (25,26). Indeed, intra-arterial pressure measurement in acutely instrumented rats, as employed in the current study, may be associated with a degree of stress (12,25). Nevertheless, in the current study, there were clear differences in blood pressure with age, and it appeared that control females were protected against the age-related increase in arterial pressure observed in males, but that IUGR females were not.…”
Section: Enhanced Age-related Increase In Arterial Pressure In Growthmentioning
confidence: 63%
“…Possible explanations for these disparities include lack of catch-up growth as observed in our model (65) or may reflect stress induced by the method employed to measure arterial pressure (25,26). Indeed, intra-arterial pressure measurement in acutely instrumented rats, as employed in the current study, may be associated with a degree of stress (12,25). Nevertheless, in the current study, there were clear differences in blood pressure with age, and it appeared that control females were protected against the age-related increase in arterial pressure observed in males, but that IUGR females were not.…”
Section: Enhanced Age-related Increase In Arterial Pressure In Growthmentioning
confidence: 63%
“…Conversely, programmed hypertension has been demonstrated in the absence of changes in birth weight or decreased nephron number in a number of animal models, including maternal overfeeding, maternal hypertension, and maternal water restriction (16,25,70,72), demonstrating that hypertension can also be programmed independently of a reduction in nephron number. Previously, we suggested potential mechanisms whereby this may occur, including alteration in the renin-angiotensin system, renal sympathetic innervation, and tubular transport mechanisms in the kidney (26).…”
Section: Mechanisms Leading To Formation Of a Low Nephron Endowmentmentioning
confidence: 99%
“…This is an area requiring further research. and hypertension may be simply coincident, and it is possible that compensatory changes in tubular function and/or renal hormonal systems must occur concomitantly for hypertension to develop (26). Furthermore, a reduced nephron number has been documented in the absence of hypertension (29,51,112) with or without changes in birth weight.…”
Section: Mechanisms Leading To Formation Of a Low Nephron Endowmentmentioning
confidence: 99%
“…The idea that a reduction in nephron number leads to the development of hypertension is well established [7]. However, programmed nephron deficit has also been described in the absence of hypertension [8], which has led to the suggestion that concomitant changes in renal function must occur in order for hypertension to develop [9]. A major candidate is the intrarenal renin-angiotensin system, which displays altered activity in several models of developmental programming [10,11].…”
Section: Introductionmentioning
confidence: 99%