Perinatal stress moderates the link between early and later emotional skills in very preterm-born children: An 11-year-long longitudinal study

Dimitrova, Nevena; Turpin, Hélène; Borghini, Ayala; Harari, Mathilde Morisod; Urben, Sébastien; Müller-Nix, Carole

doi:10.1016/j.earlhumdev.2018.04.015

Cited by 15 publications

(17 citation statements)

References 53 publications

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“…Indeed, numerous studies reported a higher prevalence of internalizing problems in this population with an increased risk for anxiety symptoms, depressive symptoms, and withdrawn behavior (Guedeney et al, 2012; Somhovd et al, 2012; Montagna and Nosarti, 2016). Dimitrova et al (2018) have recently shown that early emotional problems in 18-month-old preterm children predicted later internalizing problems at 11 years of age, but this link was moderated by the severity of perinatal stress. Preterm children who experienced high perinatal stress were at increased risk for emotional difficulties during preadolescence.…”

Section: Discussionmentioning

confidence: 99%

Effects of an Early Postnatal Music Intervention on Cognitive and Emotional Development in Preterm Children at 12 and 24 Months: Preliminary Findings

et al. 2019

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Preterm birth is associated with a higher prevalence of neurodevelopmental deficits. Indeed, preterm children are at increased risk for cognitive, behavioral, and socio-emotional difficulties. There is currently an increasing interest in introducing music intervention in neonatal intensive care unit (NICU) care. Several studies have shown short-term beneficial effects. A recent study has shown that listening to a familiar music (heard daily during the NICU stay) enhanced preterm infants’ functional connectivity between auditory cortices and subcortical brain regions at term-equivalent age. However, the long-term effects of music listening in the NICUs have never been explored. The aim of this study was to evaluate at 12 and 24 months the effects of music listening in the NICU on cognitive and emotional development in preterm children by comparing them to a preterm control group with no previous music exposure and to a full-term group. Participants were 44 children (17 full-term and 27 preterm). Preterm children were randomized to either music intervention or control condition (without music). The preterm-music group regularly listened to music from 33 weeks postconceptional age until hospital discharge or term-equivalent age. At 12 months, children were evaluated on the Bayley Scales of Infant and Toddler Development, Third Edition, then with 4 episodes of the Laboratory Temperament Assessment Battery (assessing expressions of joy, anger, and fear, and sustained attention). At 24 months, the children were evaluated with the same tests, and with 3 additional episodes of the Effortful Control Battery (assessing inhibition). Results showed that the scores of preterm children, music and control, differed from those of full-term children for fear reactivity at 12 months of age and for anger reactivity at 24 months of age. Interestingly, these significant differences were less important between the preterm-music and the full-term groups than between the preterm-control and the full-term groups. The present study provides preliminary, but promising, scientific findings on the beneficial long-term effects of music listening in the NICU on neurodevelopmental outcomes in preterm children, and more specifically on emotion mechanisms at 12 and 24 months of age. Our findings bring new insights for supporting early music intervention in the NICU.

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Section: Discussionmentioning

confidence: 99%

Effects of an Early Postnatal Music Intervention on Cognitive and Emotional Development in Preterm Children at 12 and 24 Months: Preliminary Findings

et al. 2019

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“…21-31 A mere 7 studies extended the scope of neonatal stress beyond pain-related stressors by including exposure to all stressors during the NICU stay: the quality of developmental care, medical stressors (such as all potentially stressful events during the NICU stay associated with medical care based on the Neonatal Infant Stressor Scale 3 ), and maternal separation. [32][33][34][35][36][37][38] We did not identify studies fulfilling our inclusion criteria that investigated noise or light exposure as stressors. Two studies addressed both clinical and laboratory or imaging outcomes.…”

Section: Flow Of Studies and Study Characteristicsmentioning

confidence: 99%

Neonatal Stress, Health, and Development in Preterms: A Systematic Review

et al. 2021

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CONTEXT An overview of the full range of neonatal stressors and the associated clinical, laboratory, and imaging outcomes regarding infants’ health and development may contribute to the improvement of neonatal care. OBJECTIVE To systematically review existing literature on the associations between all kinds of neonatal stressors and the health and development of preterm infants. DATA SOURCES Data sources included Embase, Medline, PsycINFO, the Cumulative Index to Nursing and Allied Health Literature, and reference lists. STUDY SELECTION Studies were eligible if they included a measure of neonatal stress during the NICU stay, reported clinical, laboratory, and/or imaging outcomes regarding health and/or development on discharge from the NICU or thereafter, included preterm infants, and were written in English or Dutch. DATA EXTRACTION Two reviewers independently screened the sources and extracted data on health and development. Study quality was assessed by using the Newcastle-Ottawa Quality Assessment Scale. RESULTS We identified 20 articles that reported on neonatal stress associated negatively with clinical outcomes, including cognitive, motor, and emotional development, and laboratory and imaging outcomes, including epigenetic alterations, hypothalamic-pituitary-adrenal axis functioning, and structural brain development. We found no evidence regarding associations with growth, cardiovascular health, parent-infant interaction, the neonatal immune system, and the neonatal microbiome. LIMITATIONS The studies were all observational and used different definitions of neonatal stress. CONCLUSIONS Neonatal stress has a profound impact on the health and development of preterm infants, and physicians involved in their treatment and follow-up should be aware of this fact.

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“…The developmental stones underlying brain development in humans are highly susceptible to adverse effects and can be modulated by maternal markers transferred vertically during pregnancy. Observational studies show that prenatal adverse environmental effects, such as maternal stress and infections affect fetal neurodevelopment and increase the risk for neurological or psychiatric disorders in future life [4][5][6][7]. Degradation of neurodevelopmental pathways may affect cognitive and mental disorders, as well as affect future brain function and increase the risk of neurodevelopmental and psychiatric disorders in later life [8].…”

Section: Microchimerism Physiopathologymentioning

confidence: 99%