Perinatal protein malnutrition alters expression of miRNA biogenesis genes Xpo5 and Ago2 in mice brain

Berardino, Bruno Gabriel; Fesser, Estefanía A.; Cánepa, Eduardo T.

doi:10.1016/j.neulet.2017.03.012

Cited by 18 publications

(11 citation statements)

References 50 publications

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“…Nutritional inadequacy alters the development of the NS, which includes the synthesis of cellular components, such as nucleic acids and proteins, in parallel with neurogenesis and glycogenesis, through cell proliferation, differentiation, migra-tion, and maturation, accompanied by a decrease in cell size (Georgieff, 2007). Also, it can alter the enzymatic activity and interfere in the synthesis of proteins (Berardino et al, 2017). Therefore, the incorporation of lipids in various structures of the brain can lead to changes in the ordered progression of brain development, logic, and memory circuitry (Duran Fernandez-Feijoo et al, 2017) -Fig.…”

Section: Malnutrition and Memorymentioning

confidence: 99%

[Retracted] Does the enriched environment alter memory capacity in malnourished rats by modulating BDNF expression?

Barros¹,

Fernandes²,

Silva³

et al. 2021

JAB

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Environmental factors interfere in the neural plasticity processes. Among these, malnutrition in the early stages of life stands out as one of the main non-genetic factors that can interfere in the morphofunctional development of the nervous system. Furthermore, sensory stimulation from enriched environments (EE) also interferes with neural development. These two factors can modify areas related to memory and learning as the hippocampus, through mechanisms related to the gene expression of brain-derived neurotrophic factor (BDNF). The BDNF may interfere in synaptic plasticity processes, such as memory. In addition, these changes in early life may affect the functioning of the hippocampus during adulthood through mechanisms mediated by BDNF. Therefore, this study aims to conduct a literature review on the effects of early malnutrition on memory and the relationship between the underlying mechanisms of EE, BDNF gene expression, and memory. In addition, there are studies that demonstrate the effect of EE reversal on exposure to changes in the functioning of hippocampal malnutrition in adult rats that were prematurely malnourished. Thereby, evidence from the scientific literature suggests that the mechanisms of synaptic plasticity in the hippocampus of adult animals are influenced by malnutrition and EE, and these alterations may involve the participation of BDNF as a key regulator in memory processes in the adult animal hippocampus.

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Section: Malnutrition and Memorymentioning

confidence: 99%

[Retracted] Does the enriched environment alter memory capacity in malnourished rats by modulating BDNF expression?

Barros¹,

Fernandes²,

Silva³

et al. 2021

JAB

View full text Add to dashboard Cite

show abstract

“…miRs are key players in epigenetic regulations which often occur in response to environmental exposure and under stress condition [8,9,50]. Altered miR expression has been found in the key brain regions related to cognitive function including hippocampus following exposure to early life stress in both humans and animals [9,[50][51][52]. However, no studies have reported the relationship between early life stress and miR-10b in the hippocampus.…”

Section: Discussionmentioning

confidence: 99%

Adverse Maternal Environment Alters MicroRNA-10b-5p Expression and Its Epigenetic Profile Concurrently with Impaired Hippocampal Neurogenesis in Male Mouse Hippocampus

Ke¹,

Huang²,

Fu³

et al. 2021

Dev Neurosci

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An adverse maternal environment (AME) predisposes adult offspring toward cognitive impairment in humans and mice. However, the underlying mechanisms remain poorly understood. Epigenetic changes in response to environmental exposure may be critical drivers of this change. Epigenetic regulators, including microRNAs, have been shown to affect cognitive function by altering hippocampal neurogenesis which is regulated in part by brain-derived neurotropic factor (BDNF). We sought to investigate the effects of AME on miR profile and their epigenetic characteristics, as well as neurogenesis and BDNF expression in mouse hippocampus. Using our mouse model of AME which is composed of maternal Western diet and prenatal environmental stress, we found that AME significantly increased hippocampal miR-10b-5p levels. We also found that AME significantly decreased DNA methylation and increased accumulations of active histone marks H3 lysine (K) 4me3, H3K14ac, and H3K36me3 at miR-10b promoter. Furthermore, AME significantly decreased hippocampal neurogenesis by decreasing cell numbers of Ki67+ (proliferation marker), NeuroD1+ (neuronal differentiation marker), and NeuN+ (mature neuronal marker) in the dentate gyrus (DG) region concurrently with decreased hippocampal BDNF protein levels. We speculate that the changes in epigenetic profile at miR-10b promoter may contribute to upregulation of miR-10b-5p and subsequently lead to decreased BDNF levels in a model of impaired offspring hippocampal neurogenesis and cognition in mice.

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“…24 In the context of developmental neuroplasticity, previous studies focused on the short-and long-lasting effects of nutrition on the offspring and on how the fetus adapts to diverse nutritional variations. [25][26][27][28] Conversely, environmental stimuli before and during pregnancy are primarily sensed by mothers, showing that the maternal life history is highly relevant to any adaptations of the offspring. 7 In this study, we applied maternal protein restriction during pregnancy to investigate the gene expression of neurotrophic factors.…”

Section: Discussionmentioning

confidence: 99%

Effects of maternal low-protein diet and spontaneous physical activity on the transcription of neurotrophic factors in the placenta and the brains of mothers and offspring rats

Fragoso

Santos

Silva

et al. 2020

J Dev Orig Health Dis

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Maternal protein restriction and physical activity can affect the interaction mother–placenta–fetus. This study quantified the gene expression of brain-derived neurotrophic factor (BDNF), neurothrophin 4, tyrosine kinase receptor B (TrkB/NTRK2), insulin-like growth factor (IGF-1), and insulin-like growth factor receptor (IGF-1r) in the different areas of mother’s brain (hypothalamus, hippocampus, and cortex), placenta, and fetus’ brain of rats. Female Wistar rats (n = 20) were housed in cages containing a running wheel for 4 weeks before gestation. According to the distance spontaneously traveled daily, rats were classified as inactive or active. During gestation, on continued access to the running wheel, active and inactive groups were randomized to receive normoprotein diet (18% protein) or a low-protein (LP) diet (8% protein). At day 20 of gestation, gene expression of neurotrophic factors was analyzed by quantitative polymerase chain reaction in different brain areas and the placenta. Dams submitted to a LP diet during gestation showed upregulation of IGF-1r and BDNF messenger RNA in the hypothalamus, IGF-1r and NTRK2 in the hippocampus, and BDNF, NTRK2, IGF-1 and IGF-1r in the cortex. In the placenta, there was a downregulation of IGF-1. In the brain of pups from mothers on LP diet, IGF-1r and NTRK2 were downregulated. Voluntary physical activity attenuated the effects of LP diet on IGF-1r in the hypothalamus, IGF-1r and NTRK2 in the hippocampus, IGF-1 in the placenta, and NTRK2 in the fetus’ brain. In conclusion, both maternal protein restriction and spontaneous physical activity influence the gene expression of BDNF, NTRK2, IGF-1, and IGF-1r, with spontaneous physical activity being able to normalize in part the defects caused by protein restriction during pregnancy.

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Perinatal protein malnutrition alters expression of miRNA biogenesis genes Xpo5 and Ago2 in mice brain

Cited by 18 publications

References 50 publications

[Retracted] Does the enriched environment alter memory capacity in malnourished rats by modulating BDNF expression?

[Retracted] Does the enriched environment alter memory capacity in malnourished rats by modulating BDNF expression?

Adverse Maternal Environment Alters MicroRNA-10b-5p Expression and Its Epigenetic Profile Concurrently with Impaired Hippocampal Neurogenesis in Male Mouse Hippocampus

Effects of maternal low-protein diet and spontaneous physical activity on the transcription of neurotrophic factors in the placenta and the brains of mothers and offspring rats

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