Perinatal Health and Translational Medicine

Perspectivas sobre o uso de modelos murinos da síndrome de down em pesquisas translacionais envolvendo função visual e motora

“…These studies were reproduced independently in two different laboratories 17,18 . More importantly, these findings have been translated into the human domain through a pilot clinical trial 19 , which reported significant improvements in the scores for one neuropsychological measure by persons with DS in the group that used memantine compared with the placebo group 20 . As aforementioned, the study of mouse models of DS has focused primarily on the cognitive and neurological components of DS.…”